Results 31 to 40 of about 2,358 (202)

The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose-containing glycoconjugate in Plasmodium asexual blood stages [PDF]

, 2016
Glycosylation is an important posttranslational protein modification in all eukaryotes. Besides glycosylphosphatidylinositol (GPI) anchors and N-glycosylation, O-fucosylation has been recently reported ...
A Cortes, AG Maier, AR Gomes, B Yilmaz, BS Crabb, C Aurrecoechea, CJ Woodrow, D Gowda, D Vasudevan, DC Gowda, DC Turnock, DJ Becker, EA Kimura, G Krishnegowda, GG Bushkin, H Ginsburg, I Matsumoto, J Le Pendu, J Rabina, J Samuelson, J Schindelin, J Thompson, JA Rodrigues, K Kirk, KE Swearingen, L Izquierdo, L Schofield, L Schwartz, M Cova, M von Itzstein, MB Doud, MJ Downie, MJ McConville, N Rovira-Graells, O Uchime, P Gerold, P Urbán, P Wang, PM Coutinho, PR Sanders, R Caputto, R Chattopadhyay, R Ramasamy, RJ Kelly, S Damerow, S Sanz, SE Lindner, T Naderer, TW Kooij, W Trager, Y Luo   +50 more
core   +2 more sources

Chemical Synthesis of Glycosylphosphatidylinositol Anchors [PDF]

, 2012
Many eukaryotic cell-surface proteins and glycoproteins are anchored to the plasma membrane by glycosylphosphatidylinositols (GPIs), a family of glycolipids that are post-translationally attached to proteins at their C-termini. GPIs and GPI-anchored proteins play important roles in many biological and pathological events, such as cell recognition and ...
Benjamin M, Swarts, Zhongwu, Guo
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study [PDF]

, 2012
Background In malaria endemic areas, host genetics influence whether a Plasmodium falciparum-infected child develops uncomplicated or severe malaria. TLR2 has been identified as a receptor for P. falciparum-derived glycosylphosphatidylinositol (GPI), and
BT Grimberg, CC John, CC Khor, Chandy C John, CM Johnson, CR Newton, D Kwiatkowski, E Noguchi, FP Mockenhaupt, G Krishnegowda, GE Grau, GE Grau, JA Greene, James W Kazura, Jennifer A Greene, JH Curfs, JJ Yim, JJ Yim, JM Bland, JT DaRe, K Haldar, KJ Livak, LN Henning, NA Sam-Agudu, Nadia Sam-Agudu, Peter A Zimmerman, PY Bochud, Robert O Opoka, S de Kossodo, T Boraska Jelavic, TD Schmittgen, V Amani, V Haehnel   +32 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia. [PDF]

, 2017
Approximately one in every 200 mammalian proteins is anchored to the cell membrane through a glycosylphosphatidylinositol (GPI) anchor. These proteins play important roles notably in neurological development and function. To date, more than 20 genes have
Ajeawung, NF, Bateman, A, Bennett, CP, Berry-Kravis, E, Campeau, PM, Carroll, CJ, Chai, G, Diggle, C, Ehresmann, S, Fairbrother, L, Gleeson, JG, Hattingh, L, Ignatius, E, Isohanni, P, Johnson, CA, Kinoshita, T, Le Deist, F, Logan, CV, Lönnqvist, T, Murakami, Y, Nguyen, TTM, Parker, MJ, Parry, DA, Perry, MS, Reimschisel, T, Rosenfeld, JA, Rousseau, J, Sheridan, E, St-Denis, A, Tardif, J, Xia, F, Zaki, MS   +31 more
core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

A Comparative Structural Study in Monolayers of GPI Fragments and Their Binary Mixtures [PDF]

, 2014
Glycosylphosphatidylinositols (GPIs), natural complex glycolipids essential for a range of biological functions, are poorly understood with regard to their interactions and arrangements in cellular membranes. To evaluate the role of the head group in the
Brezesinski, G., Seebergerab, P. H., Silva, D. Varón, Stefaniu, C., Vilotijevic, I.   +4 more
core   +2 more sources