Results 11 to 20 of about 2,358 (202)

Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides [PDF]

ACS Chemical Biology, 2021
The attachment of proteins to the cell membrane using a glycosylphosphatidylinositol (GPI) anchor is a ubiquitous process in eukaryotic cells. Deficiencies in the biosynthesis of GPIs and the concomitant production of GPI-anchored proteins lead to a series of rare and complicated disorders associated with inherited GPI deficiencies (IGDs) in humans ...
Paula A. Guerrero, Yoshiko Murakami, Ankita Malik, Peter H. Seeberger, Taroh Kinoshita, Daniel Varón Silva   +5 more
openaire   +3 more sources

Trypanosome Glycosylphosphatidylinositol Biosynthesis [PDF]

The Korean Journal of Parasitology, 2009
Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins.
Yeonchul, Hong, Taroh, Kinoshita
openaire   +2 more sources

Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus

Journal of Fungi, 2018
Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall polymers.
Jizhou Li, Isabelle Mouyna, Christine Henry, Frédérique Moyrand, Christian Malosse, Julia Chamot-Rooke, Guilhem Janbon, Jean-Paul Latgé, Thierry Fontaine   +8 more
doaj   +1 more source

Worldwide malaria incidence and cancer mortality are inversely associated [PDF]

, 2018
BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children.
Liu, P.
core   +1 more source

Thematic Review Series: Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Journal of Lipid Research, 2016
Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine ...
Taroh Kinoshita, Morihisa Fujita
doaj   +1 more source

Interaction between Plasmodium glycosylphosphatidylinositol and the host protein moesin has no implication in malaria pathology [PDF]

, 2017
Glycosylphosphatidylinositol (GPI) anchor of Plasmodium falciparum origin is considered an important toxin leading to severe malaria pathology through stimulation of pro-inflammatory responses from innate immune cells.
Amar, Berryman, Boutlis, Brasel, Cambos, Cunnington, Debierre-Grockiego, Defacque, Desjardins, Doi, Erwig, Friesen, Gazzinelli, Goldstein, Gonçalves, Gowda, Heath, Iontcheva, Itoh, Ivetic, Kamena, Kawai, Kooij, Koss, Krishnegowda, Kwon, Lackner, Langhorne, Lee, Lepenies, Liu, Louvet-Vallee, Lutz, Madaan, Matz, Moura-Alves, Neisch, Niggli, Parameswaran, Ponuwei, Ratner, Rivadeneira, Rizopoulos, Sato, Schmittgen, Schofield, Schofield, Schwende, Smart, Stevenson, Storm, Tachado, Takamatsu, Togbe, Tohme, Villadangos, Wells, Wu, Xu, Yao, Zawawi, Zhu, Zhu   +62 more
core   +2 more sources

Activation of nuclear factor kappa B in peripheral blood mononuclear cells from malaria patients [PDF]

, 2012
BACKGROUND: Malaria parasites and their products can activate a specific immune response by stimulating cytokine production in the host’s immune cells.
Chuchard Punsawad, Emsri Pongponratn, Kwannan Nantavisai, Noppadon Tangpukdee, Parnpen Viriyavejakul, Rachanee Udomsangpetch, Srivicha Krudsood, Urai Chaisri, Yaowapa Maneerat   +8 more
core   +1 more source

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
core   +1 more source

The impact of missense mutation in PIGA associated to paroxysmal nocturnal hemoglobinuria and multiple congenital anomalies-hypotonia-seizures syndrome 2: A computational study

Heliyon, 2019
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.
Ashish Kumar Agrahari, Enrico Pieroni, Gianluca Gatto, Amit Kumar   +3 more
doaj   +1 more source

Multivalent glycan arrays [PDF]

, 2019
Glycan microarrays have become a powerful technology to study biological processes, such as cell–cell interaction, inflammation, and infections. Yet, several challenges, especially in multivalent display, remain.
Bordoni, Vittorio, Delbianco, Martina, Loeffler, Felix F., Mende, Marco, Seeberger, Peter H., Tsouka, Alexandra   +5 more
core   +1 more source