Results 11 to 20 of about 1,574 (145)

Thematic Review Series: Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Journal of Lipid Research, 2016
Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine ...
Taroh Kinoshita, Morihisa Fujita
doaj   +1 more source

The impact of missense mutation in PIGA associated to paroxysmal nocturnal hemoglobinuria and multiple congenital anomalies-hypotonia-seizures syndrome 2: A computational study

Heliyon, 2019
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.
Ashish Kumar Agrahari, Enrico Pieroni, Gianluca Gatto, Amit Kumar   +3 more
doaj   +1 more source

Probing Enzymes Late in the Trypanosomal Glycosylphosphatidylinositol Biosynthetic Pathway with Synthetic Glycosylphosphatidylinositol Analogues [PDF]

ACS Chemical Biology, 2008
Glycosylphosphatidylinositol (GPI)-anchored proteins are abundant in the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness in humans and the related disease Nagana in cattle, and disruption of GPI biosynthesis is genetically and chemically validated as a drug target.
Urbaniak, Michael D., Yashunsky, Dmitry V., Crossman, Arthur, Nikolaev, Andrei V., Ferguson, Michael A. J.   +4 more
openaire   +4 more sources

Isolation and purification of glycosylphosphatidylinositols (GPIs) in the schizont stage of Theileria annulata and determination of antibody response to GPI anchors in vaccinated and infected animals

Parasites & Vectors, 2018
Background Tropical theileriosis is widely distributed from North Africa to East Asia. It is a tick-borne disease caused by Theileria annulata, an obligate two-host intracellular protozoan parasite of cattle.
Toktam Abbasnia, Ahmad Asoodeh, Gholamreza Habibi, Alireza Haghparast   +3 more
doaj   +1 more source

Hemoglobinúria paroxística noturna: relato de dois casos Paroxysmal nocturnal hemoglobinuria: two case reports

Revista Brasileira de Hematologia e Hemoterapia, 2002
A Hemoglobina Paroxística Noturna (HPN) é uma doença adquirida da stem cell hematopoética caracterizada por anemia hemolítica crônica, episódios trombóticos, e com freqüência pancitopenia. É uma desordem clonal, causada por mutação somática do gene PIG-A
Carlos J. Araújo, Francisca V.M. Soares, Francisco D. Rocha, Herivaldo F. Silva, José O.L. Nogueira, José W. Correia, Manoel P.G. Guimarães   +6 more
doaj   +1 more source

Semisynthesis of Functional Glycosylphosphatidylinositol‐Anchored Proteins [PDF]

Angewandte Chemie, 2020
AbstractGlypiation is a common posttranslational modification of eukaryotic proteins involving the attachment of a glycosylphosphatidylinositol (GPI) glycolipid. GPIs contain a conserved phosphoglycan that is modified in a cell‐ and tissue‐specific manner.
Renée F. Roller, Ankita Malik, Maria A. Carillo, Monika Garg, Antonella Rella, Marie‐Kristin Raulf, Bernd Lepenies, Peter H. Seeberger, Daniel Varón Silva   +8 more
openaire   +4 more sources

Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates

Angewandte Chemie, EarlyView.
An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho, Cindy Y. Jao, Zijun Xia, Brittany M. White‐Mathieu, Adrian Salic, Jeremy M. Baskin   +5 more
wiley   +2 more sources

Endocytosis of glycosylphosphatidylinositol-anchored proteins [PDF]

Journal of Biomedical Science, 2009
Abstract Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid moiety, the GPI-anchor is expressed in a diverse range of organisms from parasites to mammalian cells and serves to anchor a ...
Sabharanjak Shefali, Lakhan Shaheen E, De Ananya   +2 more
openaire   +3 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source