Results 11 to 20 of about 34,844 (152)
Frontiers in Medicine, 2022 Chronic kidney disease is a progressive disease that may lead to end-stage renal disease. Interstitial fibrosis develops as the disease progresses. Therapies that focus on fibrosis to delay or reverse progressive renal failure are limited.
Tsuyoshi Inoue +23 more
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The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. [PDF]
The Journal of cell biology, 1995 The urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-linked glycoprotein, plays a central role in the regulation of pericellular proteolysis and participates in events leading to cell activation. Here, we demonstrate that uPAR, on a human melanoma cell line, is localized in caveolae, flask-shaped microinvaginations of the
A, Stahl, B M, Mueller
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Complementation of essential yeast GPI mannosyltransferase mutations suggests a novel specificity for certain Trypanosoma and Plasmodium PigB proteins. [PDF]
PLoS ONE, 2014 The glycosylphosphatidylinositol (GPI) anchor is an essential glycolipid that tethers certain eukaryotic proteins to the cell surface. The core structure of the GPI anchor is remarkably well conserved across evolution and consists of NH2-CH2-CH2-PO4 ...
Leslie K Cortes +2 more
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Frontiers in Immunology, 2023 HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient.
Weiming Wang +9 more
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Implications of lipid moiety in oligomerization and immunoreactivities of GPI-anchored proteins
Journal of Lipid Research, 2013 Glycosylphosphatidylinositol (GPI) enriches GPI-anchored proteins (GPI-AP) in lipid rafts by intimate interaction of its lipid moiety with sphingolipids and cholesterol.
Jihyoun Seong +3 more
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In Vitro PIG-A Gene Mutation Assay in Human B-Lymphoblastoid TK6 Cells
Pharmaceutical Fronts, 2021 The X-linked PIG-A gene is involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. PIG-A mutant cells fail to synthesize GPI and to express GPI-anchored protein markers (e.g., CD59 and CD55).
Chang-Hui Zhou +8 more
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The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier [PDF]
Molecular Therapy, 2019 Efficient delivery of gene therapy vectors across the blood-brain barrier (BBB) is the holy grail of neurological disease therapies. A variant of the neurotropic vector adeno-associated virus (AAV) serotype 9, called AAV-PHP.B, was shown to very efficiently deliver transgenes across the BBB in C57BL/6J mice.
Juliette, Hordeaux +9 more
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The growth suppressing gas1 product is a GPI‐linked protein
FEBS Letters, 2000 Growth arrest specific (gas) 1 gene product is expressed in non‐transformed fibroblasts in response to stimuli driving cells into Go phase. Gas1 has been demonstrated to inhibit cell proliferation when over‐expressed in proliferating fibroblasts. This activity depends on a function of the p53 protein independent of its transactivating ability.
STEBEL M. +5 more
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GPI-AP release in cellular, developmental, and reproductive biology
Journal of Lipid Research, 2016 Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contain a covalently linked GPI anchor located on outer cell membranes. GPI-APs are ubiquitously conserved from protozoa to vertebrates and are critical for physiological events such as development,
Yoshitaka Fujihara, Masahito Ikawa
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Frontiers in Microbiology, 2021 The fungal cell wall is composed of a cross-linked matrix of chitin, glucans, mannans, galactomannans, and cell wall proteins with mannan chains. Cell wall mannans are directly attached to the cell wall core, while the majority of mannoproteins is ...
Lea Atanasova +6 more
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