Results 41 to 50 of about 34,844 (152)

Strain and temperature dependent aggregation of Candida auris is attenuated by inhibition of surface amyloid proteins

The Cell Surface, 2023
Candida auris is a multi-drug resistant human fungal pathogen that has become a global threat to human health due to its drug resistant phenotype, persistence in the hospital environment and propensity for patient to patient spread.
Dhara Malavia-Jones, Rhys A. Farrer, Mark H.T. Stappers, Matt B. Edmondson, Andrew M. Borman, Elizabeth M. Johnson, Peter N. Lipke, Neil A.R. Gow   +7 more
doaj   +1 more source

Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers.

PLoS Genetics
Mutations in glycosylation pathways, such as N-linked glycosylation, O-linked glycosylation, and GPI anchor synthesis, lead to Congenital Disorders of Glycosylation (CDG).
Holly J Thorpe, Raghavendran Partha, Jordan Little, Nathan L Clark, Clement Y Chow   +4 more
doaj   +1 more source

Isolation and purification of glycosylphosphatidylinositols (GPIs) in the schizont stage of Theileria annulata and determination of antibody response to GPI anchors in vaccinated and infected animals

Parasites & Vectors, 2018
Background Tropical theileriosis is widely distributed from North Africa to East Asia. It is a tick-borne disease caused by Theileria annulata, an obligate two-host intracellular protozoan parasite of cattle.
Toktam Abbasnia, Ahmad Asoodeh, Gholamreza Habibi, Alireza Haghparast   +3 more
doaj   +1 more source

Hemoglobinúria paroxística noturna: relato de dois casos Paroxysmal nocturnal hemoglobinuria: two case reports

Revista Brasileira de Hematologia e Hemoterapia, 2002
A Hemoglobina Paroxística Noturna (HPN) é uma doença adquirida da stem cell hematopoética caracterizada por anemia hemolítica crônica, episódios trombóticos, e com freqüência pancitopenia. É uma desordem clonal, causada por mutação somática do gene PIG-A
Carlos J. Araújo, Francisca V.M. Soares, Francisco D. Rocha, Herivaldo F. Silva, José O.L. Nogueira, José W. Correia, Manoel P.G. Guimarães   +6 more
doaj   +1 more source

Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma

Cellular Physiology and Biochemistry, 2017
Background/Aims: Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis.
Bettina Hieronimus, Julian Pfohl, Christian Busch, Lutz Graeve   +3 more
doaj   +1 more source

Cell Geometry Guides the Dynamic Targeting of Apoplastic GPI-Linked Lipid Transfer Protein to Cell Wall Elements and Cell Borders in Arabidopsis thaliana

PLoS ONE, 2013
During cellular morphogenesis, changes in cell shape and cell junction topology are fundamental to normal tissue and organ development. Here we show that apoplastic Glycophosphatidylinositol (GPI)-anchored Lipid Transfer Protein (LTPG) is excluded from cell junctions and flat wall regions, and passively accumulates around their borders in the epidermal
Chris Ambrose, Allan DeBono, Geoffrey Wasteneys   +2 more
openaire   +4 more sources

Classification, naming and evolutionary history of glycosyltransferases from sequenced green and red algal genomes. [PDF]

PLoS ONE, 2013
The Archaeplastida consists of three lineages, Rhodophyta, Virideplantae and Glaucophyta. The extracellular matrix of most members of the Rhodophyta and Viridiplantae consists of carbohydrate-based or a highly glycosylated protein-based cell wall while ...
Peter Ulvskov, Dionisio Soares Paiva, David Domozych, Jesper Harholt   +3 more
doaj   +1 more source

Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells

Cell Communication and Signaling, 2019
Background In previous research, we found that lamprey immune protein (LIP) possessed cytocidal activity against tumor cells, but the mechanism of the selective recognition and killing of tumor cells by LIP was not identified.
Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang, Qingwei Li   +11 more
doaj   +1 more source

Scalar nanostructure of the Candida albicans cell wall; a molecular, cellular and ultrastructural analysis and interpretation

The Cell Surface, 2020
Despite the importance of fungal cell walls as the principle determinant of fungal morphology and the defining element determining fungal interactions with other cells, few scalar models have been developed that reconcile chemical and microscopic ...
Megan D. Lenardon, Prashant Sood, Helge C. Dorfmueller, Alistair J.P. Brown, Neil A.R. Gow   +4 more
doaj   +1 more source

Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence. [PDF]

PLoS ONE, 2009
Anti-beta-glucan antibodies elicited by a laminarin-conjugate vaccine confer cross-protection to mice challenged with major fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans.
Antonella Torosantucci, Paola Chiani, Carla Bromuro, Flavia De Bernardis, Angelina S Palma, Yan Liu, Giuseppina Mignogna, Bruno Maras, Marisa Colone, Annarita Stringaro, Silvia Zamboni, Ten Feizi, Antonio Cassone   +12 more
doaj   +1 more source