mBio, 2012 Cell wall proteins (CWPs) mediate important cellular processes in fungi, including adhesion, invasion, biofilm formation, and flocculation. The current model of fungal cell wall organization includes a major class of CWPs covalently bound to β-1,6-glucan
Nicole M. Gilbert +3 more
doaj +1 more source
Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]
, 2006 During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill +44 more
core +1 more source
F1000Research, 2016 Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease that has been investigated for over one century and has revealed unique aspects of the pathogenesis and pathophysiology of a hemolytic anemia.
Lucio Luzzatto
doaj +1 more source
Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells [PDF]
, 2005 Type 2 hereditary hemochromatosis (HH) or juvenile hemochromatosis is an early onset, genetically heterogeneous, autosomal recessive disorder of iron overload.
Bjorkman, Pamela J. +4 more
core +1 more source
Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae. [PDF]
The Journal of cell biology, 1993 Glycosyl-phosphatidylinositol (GPI)-linked proteins are transported to the apical surface of epithelial cells where they undergo cholesterol-dependent clustering in membrane micro-invaginations, termed caveolae or plasmalemmal vesicles. However, the sorting machinery responsible for this caveolar-clustering mechanism remains unknown.
M P, Lisanti, Z L, Tang, M, Sargiacomo
openaire +2 more sources
Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]
, 2016 Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri +31 more
core +3 more sources
PredGPI: a GPI-anchor predictor
BMC Bioinformatics, 2008 Background Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI) anchor, which is linked to the C-terminal residue after a proteolytic cleavage occurring at the so called ω ...
Casadio Rita +2 more
doaj +1 more source
Genome-wide prediction of the polymorphic Ser gene family in Tetrahymena thermophila based on motif analysis. [PDF]
PLoS ONE, 2014 Even though antigenic variation is employed among parasitic protozoa for host immune evasion, Tetrahymena thermophila, a free-living ciliate, can also change its surface protein antigens.
Patrath Ponsuwanna +2 more
doaj +1 more source
Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages [PDF]
, 2017 Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation. hLf is recognized as a key element in the host immune defense system.
Aisen +31 more
core +2 more sources
Molecular and antigenic characterization of Trypanosoma cruzi TolT proteins [PDF]
, 2018 Background: TolT was originally described as a Trypanosoma cruzi molecule that accumulated on the trypomastigote flagellum bearing similarity to bacterial TolA colicins receptors.
Agüero, Fernan Gonzalo +13 more
core +1 more source