Results 51 to 60 of about 34,844 (152)

Anzi Heji Downregulates DNMT1 to Improve Anticardiolipin Antibody (ACA)-Positive Abortion by Regulating JAK/STAT Pathway

Natural Product Communications, 2022
Anzi Heji (AZHJ) is a traditional Chinese medicine compound prepared for long-term treatment of Anticardiolipin Antibody (ACA)-positive abortion, with small side effects and definite curative effect.
Li Miao, Qibin Lu
doaj   +1 more source

AAV-based gene therapy ameliorated CNS-specific GPI defect in mouse models

Molecular Therapy: Methods & Clinical Development
Thirty genes are involved in the biosynthesis and modification of glycosylphosphatidylinositol (GPI)-anchored proteins, and defects in these genes cause inherited GPI deficiency (IGD).
Yoshiko Murakami, Saori Umeshita, Kae Imanishi, Yoshichika Yoshioka, Akinori Ninomiya, Takehiko Sunabori, Shibi Likhite, Masato Koike, Kathrin C. Meyer, Taroh Kinoshita   +9 more
doaj   +1 more source

Immunogenic Eimeria tenella glycosylphosphatidylinositol-anchored surface antigens (SAGs) induce inflammatory responses in avian macrophages.

PLoS ONE, 2011
BackgroundAt least 19 glycosylphosphatidylinositol (GPI)-anchored surface antigens (SAGs) are expressed specifically by second-generation merozoites of Eimeria tenella, but the ability of these proteins to stimulate immune responses in the chicken is ...
Yock-Ping Chow, Kiew-Lian Wan, Damer P Blake, Fiona Tomley, Sheila Nathan   +4 more
doaj   +1 more source

Current Opinions on the Clinical Utility of Ravulizumab for the Treatment of Paroxysmal Nocturnal Hemoglobinuria

Therapeutics and Clinical Risk Management, 2021
Carmelo Gurnari,1,2 Ishani Nautiyal,1 Simona Pagliuca1,3 1Department of Translational Hematology and Oncology Research, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH, USA; 2Department of Biomedicine and Prevention, PhD in Immunology ...
Gurnari C, Nautiyal I, Pagliuca S
doaj  

Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum

BMC Bioinformatics, 2019
Background In the current scenario, designing of world-wide effective malaria vaccine against Plasmodium falciparum remain challenging despite the significant progress has been made in last few decades.
Manisha Pritam, Garima Singh, Suchit Swaroop, Akhilesh Kumar Singh, Satarudra Prakash Singh   +4 more
doaj   +1 more source

PGAP3 is expressed at increased levels in asthmatic ASM and is associated with increased ASM proliferation, contractility and expression of GATA3 and ALOX5.

PLoS ONE
Post-GPI Attachment to Proteins phospholipase 3 (PGAP3) is a glycosylphosphatidylinositol (GPI) anchor-remodeling gene found on chromosome 17q12-21, which is a locus highly linked to asthma. Genetic association studies have linked PGAP3 SNPs to increased
Eric Leslie, Marina Miller, Allison Lafuze, Sofya Svyatskaya, Gil-Soon Choi, Joshua L Kennedy, Yung-An Huang, Taylor A Doherty, David H Broide   +8 more
doaj   +1 more source

Exploring the causal relationship between plasma proteins and postherpetic neuralgia: a Mendelian randomization study

Frontiers in Neurology
BackgroundThe proteome represents a critical reservoir of potential therapeutic targets for neurological diseases. This study aims to investigate the causal relationship between plasma proteins and postherpetic neuralgia.MethodsWe performed a two-sample ...
Qiuyu Wei, Shaoyong Yu, Yi Luo, Xinghui Song, Pin Qin, Rongji Li, Weichao Sun, Weichao Sun, Jin Wang, Gang Wu   +9 more
doaj   +1 more source

Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.

PLoS Pathogens, 2012
The motility and invasion of Plasmodium parasites is believed to require a cytoplasmic actin-myosin motor associated with a cell surface ligand belonging to the TRAP (thrombospondin-related anonymous protein) family.
S Josefin Bartholdson, Leyla Y Bustamante, Cecile Crosnier, Steven Johnson, Susan Lea, Julian C Rayner, Gavin J Wright   +6 more
doaj   +1 more source

Effects of methylmercury exposure on the transcriptomes of cell lines from the rat central nervous system

Discover Toxicology
Methylmercury (MeHg) can have profound effects on cells of the nervous system, leading to DNA damage, oxidative stress, neuroinflammation, and cell death. In this study, transcriptomic changes in neuronal (B103) and glial (C6) cell lines from rat (Rattus
Laís Teixeira Bonfim, Carolina Koury Nassar Amorim, Edivaldo Herculano Corrêa de Oliveira, Wallax Augusto Silva Ferreira   +3 more
doaj   +1 more source

Protein lipidation in health and disease: molecular basis, physiological function and pathological implication

Signal Transduction and Targeted Therapy
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal changes.
Yuan Yuan, Peiyuan Li, Jianghui Li, Qiu Zhao, Ying Chang, Xingxing He   +5 more
doaj   +1 more source