Results 211 to 220 of about 36,481 (278)

Adenosine Signaling as a Central Integrative Network in Cellular Stress Responses and a Therapeutically Actionable Target in Human Disease. [PDF]

Biomolecules
Satyam SM, El-Tanani M, Alghoul WI, Abedi MM, Farook SF, Alabid IK, Dalbah M, Nasser N, Fazal S, Al-Talqani MR, Ali MM, Safaii E, Al-Shammari WBJ, Patanwala BM.   +13 more
europepmc   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Adenosine Pathway Activation Defines Genetically Linked Immunosuppressive Subtypes in Solid Tumor Brain Metastases. [PDF]

Cancers (Basel)
Bauer A, Arndt A, Reichenbach L, Gebauer N, Müller M, Neumann C, Schulz C, Steinestel K, Heller R, Chteinberg E, Busch H, Riecke A, Künstner A, Witte H.   +13 more
europepmc   +1 more source

Reciprocal Regulation of GLI1 and GLI3 Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis

International Journal of Rheumatic Diseases, Volume 29, Issue 6, June 2026.
ABSTRACT Objective We investigated the role of GLI3, a transcription factor highly expressed in the pathogenic THY1+CD34− sublining subset of rheumatoid arthritis synovial fibroblasts (RASFs), in regulating their pathogenic behavior. Methods GLI3 protein levels were quantified in freshly isolated RASF subsets by Western blotting.
Motohiko Sato, Tetsuya Saito, Yoji Komiya, Seiji Noda, Yasuhiro Tagawa, Akio Yamamoto, Hideyuki Iwai, Kentaro Endo, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Eiryo Kawakami, Tadashi Hosoya, Shinsuke Yasuda   +14 more
wiley   +1 more source

A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma. [PDF]

Cancer Discov
Berico P, Flores Yanke A, Vand-Rajabpour F, Do C, Simonin Wilmer I, Delclaux I, Muijlwijk T, Stagnitta R, Vázquez-Cruz ME, Sakellaropoulos T, Costa MR, Moraes Sousa-Squiavinato AC, Krogsgaard M, Moshiri AS, Osman I, Skok JA, Possik PA, Robles-Espinoza CD, Lund AW, Schober M, Hernando E.   +20 more
europepmc   +1 more source

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias, Claudia C. Stroupe, Thatiane Russo, Thomas J. Hope   +3 more
wiley   +1 more source

Serum CD73 activity as a biomarker of hypoxemia in COVID-19 patients. [PDF]

Sci Rep
Le Borgne P, Bilbault P, Clere-Jehl R, Favre J, Lefebvre F, Ubeaud-Séquier G, Ghazouani FE, Demiselle J, Toti F, Meziani F, Kauffenstein G.   +10 more
europepmc   +1 more source

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali, Elie Salem Sokhn, Charbel Khalil, Fatima A. Saleh   +3 more
wiley   +1 more source

Screening of a quinonoid compounds library identifies decylubiquinone as an antioxidant and anti-apoptotic agent against glucocorticoid-induced osteoporosis via CD39/CD73/adenosine axis. [PDF]

Bioact Mater
Xu Y, Xu W, Zhang W, Li S, Zhang D, Lin X, Sun Q, Wang Y, Hu P, Si H.   +9 more
europepmc   +1 more source

Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT The goal of achieving clinical operational tolerance in liver transplantation has sparked significant interest, driven by the desire to mitigate the long‐term adverse effects of immunosuppression. Advances in understanding the immunological mechanisms underpinning operational tolerance in liver transplantation have highlighted the central role
Emilia Knioła, Bartosz Foroncewicz, Jan Lerut, Leszek Pączek, Krzysztof Mucha   +4 more
wiley   +1 more source