Results 81 to 90 of about 39,639 (239)

PURINERGIC REGULATION OF BASIC PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES

Медицинская иммунология, 2018
Purinergic signaling has been actively studied over recent years. It happens, due to its involvement in pathogenesis of various diseases and pathologies such as infectious and non-infectious inflammation, tumor growth, graft-versus-host disease ...
A. S. Golovkin, I. A. Asadullina, I. V. Kudryavtsev   +2 more
doaj   +1 more source

GelMA‐Based Hydrogel Encapsulating Astragalus Polysaccharides and Umbilical Cord Mesenchymal Stem Cell Exosomes Promotes Full‐Thickness Skin Wound Healing

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Wound healing involves excessive oxidative stress and cellular dysfunction, while current single therapies remain inadequate. Astragalus polysaccharides (APS) and exosomes (Exos) possess antioxidative and regenerative properties, and gelatin methacryloyl (GelMA) hydrogel provides a biocompatible platform for localized delivery. Here,
Jingwen Tian, Xiangjing Zhao, Jingxian Xie, Zheng Huang, Pengbo Song, Suzhuang Hong, Cailing Tong, Zhongquan Qi   +7 more
wiley   +1 more source

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

, 2010
Extracellular adenosine is a potent immunosuppressor that accumulates during tumor growth. We performed proof-of-concept studies investigating the therapeutic potential and mechanism of action of monoclonal antibody (mAb)-based therapy against CD73, an ...
Upulie Divisekera, Delphine Denoyer, Sandra Pommey, Pommey, Sandra, Denoyer, Delphine, Divisekera, Upulie, McLaughlin, Nicole, Dwyer, Karen M., Mark J. Smyth, Stagg, John, Janelle Sharkey, Sharkey, Janelle, Nicole McLaughlin, Karen M. Dwyer, Smyth, Mark J., John Stagg   +15 more
core   +1 more source

Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5′-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients

OncoImmunology, 2018
Background: The adenosine A2a receptor (A2aR) and the adenosine synthesizing enzyme CD73 have recently evolved as a novel immunotherapeutic target. However, little is known about epigenetic modification of the encoding genes ADORA2A and NT5E. Methods: In
Timo J. Vogt, Heidrun Gevensleben, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Diane Goltz, Dimo Dietrich   +7 more
doaj   +1 more source

Role of CD73/adenosine/A2A pathway in the modulation of inflammatory processes

, 2017
Manipulation of the course or of the extension of an inflammatory reaction may include the effort not only to inhibit pro-inflammatory pathways but also through an approach able to enhance endogenous anti-inflammatory processes.
Elisabetta Caiazzo, Pellegrino Lippiello, Carla Cicala, Armando Ialenti   +3 more
core  

CD73 expression and clinical significance in human metastatic melanoma

, 2018
CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.
Caux, C., Treilleux, I., Michielin, O., Inês Monteiro, Monteiro, I., Vigano, S., Romero, P., Ménétrier-Caux, C., Mohamed Faouzi, Pedro Romero, Faouzi, M., Laurence de Leval, Selena Vigano, Olivier Michielin, Christophe Caux, Christine Ménétrier-Caux, Isabelle Treilleux, de Leval, L., Vigano S, de Leval L, de Leval, Laurence, Michielin, Olivier, Faouzi, Mohamed, Caux, Christophe, Romero P, Treilleux, Isabelle, Treilleux I, Michielin O, Caux C, Ménétrier-Caux C, Ménétrier-Caux, Christine, Monteiro, Inês, Vigano, Selena, Romero, Pedro, Monteiro I, Faouzi M   +35 more
core   +1 more source

Downregulation of CD73 associates with T cell exhaustion in AML patients

Journal of Hematology & Oncology, 2019
Background Successful treatment for acute myeloid leukemia (AML) remains challenging. Inhibiting immune checkpoint to enhance anti-tumor response is an attractive strategy for effective leukemia therapeutics.
Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng   +10 more
doaj   +1 more source

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

Interdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim, Eun‐Kyung Min, Choon‐Mi Lee, Kun‐Hee Na, Chan Hum Park, YunJae Jung, Hwa‐Yong Lee   +6 more
wiley   +1 more source

CD73 polymorphisms are associated with schizophrenia

Purinergic Signalling
Abstract Ecto-5’-nucleotidase/CD73 enzyme plays a key role in the regulation of extracellular adenosine levels, thereby exerting influence on adenosine homeostasis. Emerging evidence suggests that perturbations in purines and ecto-5’-nucleotidase activity are associated with an augmented susceptibility to schizophrenia.
Peng, He-Xia, Zhang, Li-Li, Jiang, Dan, Jian, Na, Zhang, Ting-Mei, Luo, Jia-Guo, Yin, Hai-Yan   +6 more
openaire   +2 more sources

A Novel Mechanism of B Cell-Mediated Immune Suppression through CD73 Expression and Adenosine Production [PDF]

, 2014
Immune suppression by regulatory T cells and regulatory B cells is a critical mechanism to limit excess inflammation and autoimmunity. IL-10 is considered the major mediator of B cell induced immune suppression.
Al-Abed, Y., Kaku, H., Cheng, K. F., Rothstein, T. L.   +3 more
core   +1 more source