Results 81 to 90 of about 36,605 (250)
Advanced Science, EarlyView.A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi +12 more
wiley +1 more source
Biochemické nástroje k cílení imunomodulačního receptoru CD73 [PDF]
, 2022 New approaches to cancer treatment are investigated because cancer remains one of the most abundant causes of death. One of the promising fields of oncology is immunotherapy, which is based on the activation of immunity to eliminate malignant cells ...
Poukarová, Magdalena
core
Effect of various anti-CD73 antibodies on blocking the activity of CD73 bound MDA-MB-231 cells. [PDF]
, 2019 Effect of various anti-CD73 antibodies on blocking the activity of CD73 bound MDA-MB-231 cells.
Said A. Goueli (7548320) +1 more
core +1 more source
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, EarlyView.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
CD73 facilitates EMT progression and promotes lung metastases in triple-negative breast cancer
Scientific Reports, 2021 CD73 is a cell surface ecto-5′-nucleotidase, which converts extracellular adenosine monophosphate to adenosine. High tumor CD73 expression is associated with poor outcome among triple-negative breast cancer (TNBC) patients.
Nataliia Petruk +9 more
doaj +1 more source
Advanced Science, EarlyView.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source
The CD39/CD73/Adenosine and NAD/CD38/CD203a/CD73 Axis in Cutaneous T-Cell Lymphomas [PDF]
CellsCutaneous T-cell lymphoma (CTCL), characterized by malignant T-cell proliferation primarily in the skin, includes subtypes such as mycosis fungoides (MF) and Sézary syndrome (SS). The tumor microenvironment (TME) is central to their pathogenesis, with flow cytometry and histology being the gold standards for detecting malignant T cells within the TME ...
Liyun Lin +13 more
openaire +4 more sources
The role of purinergic signaling and cytokine network in the inflammatory process
Ветеринария сегодняIntroduction. Inflammation is a complex biological process essential for host defense against pathogens and tissue repair. This process is regulated by a variety of signaling molecules, among which purines and cytokines play an important role. Purinergic
V. V. Mosyagin +3 more
doaj +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
CD73‐generated adenosine promotes osteoblast differentiation [PDF]
Journal of Cellular Physiology, 2012 AbstractCD731 is a GPI‐anchored cell surface protein with ecto‐5′‐nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73‐generated adenosine in bone tissue are largely unknown. To address this
Masahide, Takedachi +11 more
openaire +2 more sources