Results 61 to 70 of about 39,639 (239)

CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis. [PDF]

PLoS ONE, 2017
CD73 works together with CD39 to convert extracellular ATP to immunoregulatory adenosine, thus inhibiting inflammation. TGFβ-mediated CD73 expression on 'regulatory' Th17 cells limits their ability to eradicate tumors, similar to the immunosuppressive ...
Gerard Hernandez-Mir, Mandy J McGeachy
doaj   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Inhibition by adenosine of fEPSP recordings in hippocampal slices from CD73^+/+ and CD73^−/− mice.

, 2013
(a) Representative traces of fEPSPs; numbers 1–6 correspond to before and during superfusion of slices with adenosine (10, 25, 50 or 100 µM) or adenosine (100 µM) and DPCPX (1 µM) as indicated in (b).
Wei Xiong (58411), Chao Sun (139686), Benedict C. Albensi (318170), Fiona E. Parkinson (318171), Stephanie Chu (318169), Dali Zhang (318168)   +5 more
core   +1 more source

Impaired effector functions of CD73⁺CD8⁺ T cells compared to CD73^-CD8⁺ T cells in PBMCs of HIV-infected individuals.

, 2022
(A) Representative flow cytometry plots, and (B) Cumulative data of TNF-α, IFN-γ, and IL-2 expression in CD73+ versus CD73-CD8 T cells upon stimulation of PBMCs from HIV-infected individuals with anti-CD3/CD28. (C) Cumulative data of TNF-α, and (D) IFN-γ
Shokrollah Elahi (148819), Shima Shahbaz (6087143), Isobel Okoye (11018937), Gregg Blevins (12290128)   +3 more
core   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Inhibition by ATP of fEPSP recordings in hippocampal slices from CD73^+/+ and CD73^−/− mice.

, 2013
(a) Representative traces of fEPSPs; numbers 1–6 correspond to before and during superfusion of slices with ATP (10, 25, 50 or 100 µM) or ATP (100 µM) and DPCPX (1 µM) as indicated in (b).
Wei Xiong (58411), Chao Sun (139686), Benedict C. Albensi (318170), Fiona E. Parkinson (318171), Stephanie Chu (318169), Dali Zhang (318168)   +5 more
core   +1 more source

Radiolabeled Human Monoclonal Antibody 067-213 has the Potential for Noninvasive Quantification of CD73 Expression

, 2020
Background: CD73 is an ectonucleotidase regulating extracellular adenosine concentration and plays an important role in adenosine-mediated immunosuppressive pathways.
Hitomi Sudo, David Alexander, Tatsuya Higashi, Hiroyuki Tsuda, Aya Sugyo, Atsushi B. Tsuji, Yoshikazu Kurosawa, Gene Kurosawa, Tsuneo Saga   +8 more
core   +1 more source

The role of purinergic signaling and cytokine network in the inflammatory process

Ветеринария сегодня
Introduction. Inflammation is a complex biological process essential for host defense against pathogens and tissue repair. This process is regulated by a variety of signaling molecules, among which purines and cytokines play an important role. Purinergic
V. V. Mosyagin, E. A. Isakova, G. F. Ryzhkova, I. P. Mosyagina   +3 more
doaj   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Fluorescent Probes for Ecto-5′-nucleotidase (CD73) [PDF]

, 2020
Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive ...
Renn C., Al-Hroub H., Rolshoven G., Schakel L., Losenkova K., Schmidt-Wolf I. G. H., Zimmermann H., Schmies C. C., Wang Y., Garofano F., Yegutkin G. G., Idris R. M., Muller C. E., Ingo G. H. Schmidt-Wolf, Georg Rolshoven, Christa E. Müller, Karolina Losenkova, Laura Schäkel, Riham M. Idris, Constanze C. Schmies, Christian Renn, Herbert Zimmermann, Gennady G. Yegutkin, Haneen Al-Hroub, Francesca Garofano, Yulu Wang   +25 more
core   +1 more source