Results 61 to 70 of about 36,605 (250)

Bispecific antibodies targeting human CD73 [PDF]

, 2017
The present invention relates to a bispecific antibody targeting CD73. In particular, the present invention relates to a bispecific antibody targeting different epitopes on CD73 or a bispecific antibody targeting an epitope on CD73 and an epitope on a ...
Gammelgaard, Odd Lilleng, Ditzel, Henrik
core   +2 more sources

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians [PDF]

, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Alfonso Cruz-Jentoft, Almudena Crooke, Martínez López, Joaquín, Martínez-Henández, Juan, Jesús Pintor, Crooke Álvarez, Almudena, Huete Toral, Fernando, Pintor, Jesús, Juan Martínez-Henández, Fernando Huete-Toral, Pintor Just, Jesús Jerónimo, Martínez-López, Joaquín, Crooke, Almudena, Cruz-Jentoft, Alfonso, Cruz Jentoft, Alfonso, Huete-Toral, Fernando, Joaquín Martínez-López, Martínez Henández, Juan   +17 more
core   +1 more source

CD73 polymorphisms are associated with schizophrenia

Purinergic Signalling
Abstract Ecto-5’-nucleotidase/CD73 enzyme plays a key role in the regulation of extracellular adenosine levels, thereby exerting influence on adenosine homeostasis. Emerging evidence suggests that perturbations in purines and ecto-5’-nucleotidase activity are associated with an augmented susceptibility to schizophrenia.
Peng, He-Xia, Zhang, Li-Li, Jiang, Dan, Jian, Na, Zhang, Ting-Mei, Luo, Jia-Guo, Yin, Hai-Yan   +6 more
openaire   +2 more sources

CD39/CD73/A2AR pathway and cancer immunotherapy

Molecular Cancer, 2023
AbstractCancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes tumor cell immunologic escape. The sequential conversion of extracellular ATP into adenosine by two important cell-surface ectonucleosidases CD39 and CD73 play critical roles in reshaping an ...
Chenglai Xia, Shuanghong Yin, Kenneth K. W. To, Liwu Fu   +3 more
openaire   +3 more sources

Role of CD73/adenosine/A2A pathway in the modulation of inflammatory processes [PDF]

, 2017
Manipulation of the course or of the extension of an inflammatory reaction may include the effort not only to inhibit pro-inflammatory pathways but also through an approach able to enhance endogenous anti-inflammatory processes.
Elisabetta Caiazzo, Pellegrino Lippiello, Carla Cicala, Armando Ialenti   +3 more
core  

CD73: agent development potential and its application in diabetes and atherosclerosis

Frontiers in Immunology
CD73, an important metabolic and immune escape-promoting gene, catalyzes the hydrolysis of adenosine monophosphate (AMP) to adenosine (ADO). AMP has anti-inflammatory and vascular relaxant properties, while ADO has a strong immunosuppressive effect ...
Dan Liu, Jingjing Zhao, Ling Li, Jie Wang, Chao Wang, Yudong Wu, Yucun Huang, Dongming Xing, Dongming Xing, Wujun Chen   +9 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

CD73: A Novel Target for Cancer Immunotherapy [PDF]

Cancer Research, 2010
Abstract The promise of cancer immunotherapy has not been translated into clinical successes, in large part because of tumor-associated immune suppression that blocks effective antitumor immunity. Recent findings show a tumor-induced immunosuppressive mechanism, whereby tumor-derived CD73 functions as an ecto-enzyme to produce ...
openaire   +2 more sources

CD73 promotes colitis‑associated tumorigenesis in mice

Oncology Letters, 2020
Patients with inflammatory bowel disease (IBD) are at a higher risk of developing colitis-associated colorectal cancer. The aim of the present study was to investigate the role of CD73 in IBD-associated tumorigenesis. A mouse model of colitis-associated tumorigenesis (CAT) induced by azoxymethane and dextran sulfate sodium was successfully constructed.
Liu, Xuan-Hui, Wu, Xian-Rui, Lan, Nan, Zheng, Xiao-Bin, Zhou, Chi, Hu, Tuo, Chen, Yu-Feng, Cai, Ze-Rong, Chen, Ze-Xian, Lan, Ping, Wu, Xiao-Jian   +10 more
openaire   +3 more sources

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source