Results 61 to 70 of about 38,724 (265)

CD73 in triple-negative breast cancer [PDF]

, 2023
CD73 is a membrane-bound receptor that converts AMP to adenosine. Its overexpression in tumors is associated with poor outcomes in triple-negative breast cancer (TNBC) patients.
Petruk, Nataliia
core  

CD73 represses pro-inflammatory responses in human endothelial cells [PDF]

, 2010
Background: CD73 is a 5'-ectonucleotidase that produces extracellular adenosine, which then acts on G protein-coupled purigenic receptors to induce cellular responses.
Gruenewald, Jana K. G., Ridley, Anne J.
core   +4 more sources

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

CD73 overexpression in ADSCs accelerates bladder repair by regulating the NFκB/NLRP3/caspase-1 signaling axis in neurogenic bladder rats

npj Regenerative Medicine
Neurogenic bladder (NB) is a disabling condition lacking effective therapies. This study investigated whether CD73-expressing adipose-derived stem cells (ADSCs) promote bladder repair in a rat model of NB and explored the underlying mechanisms.
Guanqun Zhu, Rui Zhang, Jiao Huang, Zongliang Zhang, Kai Zhao, Xinbao Yin, Xiaokun Yang, Zaiqing Jiang, Han Yang, Woong Jin Bae, Ke Wang   +10 more
doaj   +1 more source

Isoflurane transiently increases CD73 activity without changing CD73 synthesis in cultured endothelial cells.

, 2014
A. Human umbilical vein endothelial (EA.hy926) cells treated with 2.5% isoflurane showed a significant but transient induction of CD73 activity. CD73 activity peaked at 3 hr and then decreased to near baseline at 6–16 hr after isoflurane treatment (N = 6–
Kevin M. Brown (182605), Mihwa Kim (580181), H. Thomas Lee (580184), Katelyn Yu-Mi Kim (580183), Ahrom Ham (580182)   +4 more
core   +1 more source

CD73 as a prognostic biomarker in human pancreatic cancer [PDF]

, 2021
Cell surface protein CD73 has important role in sustaining immune homeostasis as the key regulator of extracellular adenosine which mediates immunosuppression and angiogenesis.
Laakkonen, Joni
core  

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

The role of purinergic signaling and cytokine network in the inflammatory process

Ветеринария сегодня
Introduction. Inflammation is a complex biological process essential for host defense against pathogens and tissue repair. This process is regulated by a variety of signaling molecules, among which purines and cytokines play an important role. Purinergic
V. V. Mosyagin, E. A. Isakova, G. F. Ryzhkova, I. P. Mosyagina   +3 more
doaj   +1 more source

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians [PDF]

, 2017
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Alfonso Cruz-Jentoft, Almudena Crooke, Martínez López, Joaquín, Martínez-Henández, Juan, Jesús Pintor, Crooke Álvarez, Almudena, Huete Toral, Fernando, Pintor, Jesús, Juan Martínez-Henández, Fernando Huete-Toral, Pintor Just, Jesús Jerónimo, Martínez-López, Joaquín, Crooke, Almudena, Cruz-Jentoft, Alfonso, Cruz Jentoft, Alfonso, Huete-Toral, Fernando, Joaquín Martínez-López, Martínez Henández, Juan   +17 more
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source