Results 41 to 50 of about 36,605 (250)
Effect of AMP on CD73+/+ and CD73−/− BMDCs. [PDF]
, 2012 A) AMP induced migration of immature BMDC generated from CD73+/+ and CD73−/− animals. DCs were stimulated with the indicated concentrations of AMP for 90 min.
Stephan Sorichter (163542) +10 more
core +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Human CD4+CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells [PDF]
Clinical and Experimental Immunology, 2014 SummaryWhile murine CD4+CD39+ regulatory T cells (Treg) co-express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive adenosine (ADO), surface co-expression of CD73 on human circulating CD4+CD39+Treg is rare. Therefore, the ability of human Treg to produce and utilize ADO for suppression remains unclear.
Schuler, P. J. +10 more
openaire +3 more sources
PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment
Molecular & Cellular Oncology, 2017 The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells.
Ya-Ting Wang, Ruey-Hwa Chen
doaj +1 more source
In Vivo Immunological Effects of CD73 Deficiency [PDF]
Cellular Physiology and Biochemistry, 2019 The extracellular ecto-5'-nucleotidase (CD73) is involved in the production of immunosuppressive adenosin (Ado), which can influence different immune cells through the specific adenosine receptors. The main aim of this work was to characterize immune cell populations as well as serum cytokine level in healthy CD73-deficient mice compared to healthy ...
Thomas Adam +6 more
openaire +3 more sources
The first CD73-instructed supramolecular hydrogel [PDF]
Journal of Colloid and Interface Science, 2015 Enzymatic supramolecular hydrogelation is a simple, controllable, and novel strategy for preparation of soft colloidal materials, which allows the integration of self-assembly with enzyme associated biological processes. The development of more enzymes involve in hydrogelation is a subject of developing useful soft colloids. In this work, an ectoenzyme,
Dongdong Wu +5 more
openaire +2 more sources
CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice
Frontiers in Immunology, 2020 Previous studies have shown that CD73 is pivotal in the conversion of pro-inflammatory adenosine triphosphate into anti-inflammatory adenosine and that immune cells of the same type that express different levels of CD73 are functionally distinct. In this
MinHee K. Ko +3 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2016 Nucleotide metabolism in endothelium is variable between different species. Recent studies demonstrated that this variability could contribute coagulation dysfunction, even though organs of the alpha1,3-galactosyltransferase gene knockout pig were ...
Keon Bong Oh +7 more
doaj +1 more source
Fluorescent Probes for Ecto-5′-nucleotidase (CD73) [PDF]
ACS Medicinal Chemistry Letters, 2020 Ecto-5'-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive microenvironment.
Constanze C. Schmies +12 more
openaire +3 more sources
Isoflurane transiently increases CD73 activity without changing CD73 synthesis in cultured endothelial cells. [PDF]
, 2014 A. Human umbilical vein endothelial (EA.hy926) cells treated with 2.5% isoflurane showed a significant but transient induction of CD73 activity. CD73 activity peaked at 3 hr and then decreased to near baseline at 6–16 hr after isoflurane treatment (N = 6–
Kevin M. Brown (182605) +4 more
core +1 more source