Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors. [PDF]
Angew Chem Int Ed EnglFluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Dobelmann C +23 more
europepmc +3 more sources
CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice
Frontiers in Immunology, 2020 Previous studies have shown that CD73 is pivotal in the conversion of pro-inflammatory adenosine triphosphate into anti-inflammatory adenosine and that immune cells of the same type that express different levels of CD73 are functionally distinct. In this
MinHee K. Ko +3 more
doaj +1 more source
CD73 promotes tumor growth and metastasis [PDF]
OncoImmunology, 2012 Our recent data and that of others demonstrate that both tumor and host CD73-generated adenosine promote tumor growth and metastasis in a multifactorial manner. Results with small molecule inhibitors or monoclonal antibodies against CD73 in multiple tumor models suggest that CD73 is a previously unappreciated important target for effective cancer ...
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CD73 promotes colitis‑associated tumorigenesis in mice
Oncology Letters, 2020 Patients with inflammatory bowel disease (IBD) are at a higher risk of developing colitis-associated colorectal cancer. The aim of the present study was to investigate the role of CD73 in IBD-associated tumorigenesis. A mouse model of colitis-associated tumorigenesis (CAT) induced by azoxymethane and dextran sulfate sodium was successfully constructed.
Liu, Xuan-Hui +10 more
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From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]
, 2015 Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
core +2 more sources
Cd73: An Emerging Checkpoint for Cancer Immunotherapy [PDF]
Immunotherapy, 2019 CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes tumor progression by suppressing antitumor immune response and promoting angiogenesis. The inhibition of CD73, in combination with immune checkpoint blockade, targeted therapy or conventional therapy, improves antitumor effects in numerous preclinical mouse models of ...
Siqi, Chen +6 more
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Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases
OncoImmunology, 2017 The emerging role for CD73 in driving cancer growth and metastasis has presented opportunities to develop anti-CD73 monoclonal antibodies (mAbs) in the treatment of human cancers.
Dipti Vijayan +9 more
doaj +1 more source
CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis. [PDF]
PLoS ONE, 2017 CD73 works together with CD39 to convert extracellular ATP to immunoregulatory adenosine, thus inhibiting inflammation. TGFβ-mediated CD73 expression on 'regulatory' Th17 cells limits their ability to eradicate tumors, similar to the immunosuppressive ...
Gerard Hernandez-Mir, Mandy J McGeachy
doaj +1 more source
Oral plaque from Type 2 diabetic patients reduces the clonogenic capacity of dental pulp-derived mesenchymal stem cells [PDF]
, 2019 Type 2 diabetes (T2D) is a major metabolic disease and a key epigenetic risk factor for the development of additional clinical complications. Among them, periodontitis (PD), a severe inflammatory disease ascribable to a dysregulated physiology and ...
Bordin, Antonella +9 more
core +1 more source
CD73: double-breasted suit [PDF]
Science-Business eXchange, 2010 Australian researchers have shown that an anti-CD73 antibody can reduce both primary tumor growth and metastasis in animal models of breast cancer. The strategy may provide an option for advanced disease and treatment-resistant disease if unwanted immune side effects can be avoided.
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