Results 121 to 130 of about 34,165 (229)

Supplementary Figures S1 through S7 from CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8⁺ T Cells

, 2018
(1) Figure S1. Expression of CD39 and CD73 on CD8+T cells from different cancer models and tumor-free mice. (2) Figure S2. Expression of CD39 and CD73 on tumor-infiltrating CD45+ cells.
Carolina L. Montes (11188473), Sabrina N. Bossio (11188449), Andrés del Castillo (14929430), Cintia L. Araujo Furlan (5846315), Adriana Gruppi (168642), Christine Sedlik (6485543), Nicolás Núñez (14929427), Eva V. Acosta Rodríguez (11188470), Fernando P. Canale (5927951), Jimena Tosello Boari (11188446), Marta Ledesma (636899), María C. Ramello (5804378), Melisa Gorosito Serrán (5846327), Eliane Piaggio (3174405)   +13 more
core   +1 more source

CD39 expressed by CD8⁺ T cells in HCV infection is enzymatically active.

, 2015
(A) Flow cytometry sorting gates of CD39+ and CD39– CD8+ T cells and CD39+ CD25+ CD4+ Tregs used for rpHPLC analysis of CD39 activity. (B) Summary of CD39 expression level relative to Tregs in the same subjects.
Jernej Godec (816310), W. Nicholas Haining (154505), Wolfgang G. Junger (397608), E. John Wherry (212944), Paul Klenerman (33807), Cormac Cosgrove (358780), Galit Alter (91383), Prakash K. Gupta (816309), Simon C. Robson (301209), Philip J. R. Goulder (83293), Carola Ledderose (355829), David Wolski (5665549), Kathleen Yates (816311), Kristen E. Pauken (816312), Arlene H. Sharpe (154508), Georg M. Lauer (620394), Emily Adland (452953)   +16 more
core   +1 more source

Calculated CD73/CD39 content per mg heart tissue under basal conditions and after I/R.

, 2013
The number of cell surface molecules was calculated by multiplying the absolute cell count/mg heart tissue with the percentage of CD73+/CD39+ cells and with the number of CD73/CD39 molecules on those cells. A: Calculated CD73 content per mg heart tissue.
Nadine Borg (326505), Jürgen Schrader (326509), Sandra Burghoff (326507), Florian Bönner (326503)   +3 more
core   +1 more source

CD39 EXPRESSION MODULATES ISCHEMIA INDUCED DIASTOLIC DYSFUNCTION

, 2012
CD39 EXPRESSION MODULATES ISCHEMIA INDUCED DIASTOLIC ...
Anthony JF d'Apice (14541305), Debra G Wheeler (13612282), Richard J Gumina (13355988), Sibel Gokce (19214131), Shouvik D Mahamud (13612690), Zhaobin Xu (381351), Karen M Dwyer (14541281), Simon C Robson (13355982), Peter J Cowan (13355985)   +8 more
core  

Analysis of CD39/ATP Diphosphohydrolase (ATPDase) Expression in Endothelial Cells, Platelets and Leukocytes

, 1999
SummaryPurinergic signaling may influence hemostasis, inflammatory responses and apoptosis. Therefore, hydrolysis of extracellular ATP and ADP by the ATP diphosphohydrolase (ATPDase) could regulate these processes.
Simon Robson, Jean Sévigny, Katarzyna Koziak, Jonathan Siegel, Elzbieta Kaczmarek   +4 more
core   +1 more source

Cancer immunotherapy by adenosinergic CD39 and CD73 as emerging immune checkpoints

Discover Oncology
Extracellular adenosine has recently been identified as an immunological checkpoint mediator that hinders the immune response to malignancies. The production of adenosine is facilitated by the enzymatic activity of CD39 and CD73.
Xinyu Yin, Ying Yang, Songjiang Liu
doaj   +1 more source

CD39 dynamics in tuberculosis: a potential biomarker of immune dysregulation and T cell exhaustion

Frontiers in Immunology
BackgroundTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health crisis complicated by immune dysregulation and T cell exhaustion.
Ling Hao, Ling Hao, Qari Muhammad Imran, Nadeem Ullah   +3 more
doaj   +1 more source

T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis

International Journal of Nanomedicine
Xiaoshan Yang,1– 3,* Yang Zhou,2,3,* Fuxing Zhou,4,* Lili Bao,2,3 Zhengyan Wang,5 Zihan Li,2,3 Feng Ding,2,3 Huijuan Kuang,6,7 Huan Liu,8 Shenglong Tan,1 Xinyuan Qiu,1 Huan Jing,9 Shiyu Liu,2,3 Dandan Ma1 1Department of Endodontics ...
Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D   +13 more
doaj  

NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine

, 2016
Interferon gamma (IFNγ)-producing CD8+ T cells (Tc1) play important roles in immunological disease. We now report that CD3/CD28-mediated stimulation of CD8+ T cells to generate Tc1 cells, not only increases IFNγ production but also boosts the generation ...
Moss, Alan, Robson, Simon, Bai, A, Wu, Yan, Rothweiler, Sonja, Serena Longhi, Maria, Junger, Wolfgang   +6 more
core   +1 more source

Elevated Adenosine Kinase and Decreased <i>ENTPD1</i> mRNA Levels in Peripheral Blood Leukocytes of Patients with MASLD Differentiate Metabolic Dysfunction-Associated Steatohepatitis from Hepatic Steatosis. [PDF]

Diseases
Kurbatova I, Zhulai G, Dudanova O, Topchieva L.   +3 more
europepmc   +1 more source