Results 71 to 80 of about 34,165 (229)

The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration

, 2008
Microglia is activated by brain injury. They migrate in response to ATP and although adenosine alone has no effect on wild type microglial migration, we show that inhibition of adenosine receptors impedes ATP triggered migration.
Gertz, K., Simon C. Robson, Enjyoji, K., Faerber, K., Nolte, C., Prinz, V., Ulrike Pannasch, Markworth, S., Pannasch, U., Endres, M., Vincent Prinz, Kettenmann, H., Kronenberg, G., Keiichi Enjyoji, Sören Markworth, Ingo Bechmann, Katrin Färber, Christiane Nolte, Golo Kronenberg, Matthias Endres, Helmut Kettenmann, Bechmann, I., Karen Gertz, Robson, S.C.   +23 more
core   +1 more source

CD39 as a metabolic rheostat of immunoregulation

Cellular & Molecular Immunology
L. Zhang et al. proposed novel immunotherapeutic strategies to limit the progression of inflammatory bowel diseases by targeting the interplay between the membrane-bound CD39 molecule and cellular metabolism — specifically, by increasing regulatory T-cell function through the modulation of glucose metabolism and suppressing pathogenic proinflammatory ...
Barnaba, Vincenzo, Sozzani, Silvano
openaire   +2 more sources

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

High circulating CD39+ regulatory T cells predict poor survival for sepsis patients

International Journal of Infectious Diseases, 2015
Background: Sepsis encompasses two phases, the ‘hyper’-reactive phase and the ‘hypo’-reactive phase. The initial inflammatory stage is quickly counterbalanced by an anti-inflammatory response, which compromises the immune system, leading to immune ...
Huihuang Huang, Ruonan Xu, Fang Lin, Chunmei Bao, Siyu Wang, Chengcheng Ji, Ke Li, Lei Jin, Jingsong Mu, Yonggang Wang, Lei Li, Lijian Sun, Biao Xu, Zheng Zhang, Fu-Sheng Wang   +14 more
doaj   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

Abundance of CD73 and CD39 on leukocytes in blood and heart under basal conditions.

, 2013
A: CD73+ and CD39+ cells per leukocyte population in cardiac tissue. B: CD73/CD39 surface density on CD73+/CD39+ cells per leukocyte population in cardiac tissue. C: CD73+ and CD39+ cells per leukocyte population in blood. D: CD73/CD39 surface density on
Nadine Borg (326505), Jürgen Schrader (326509), Sandra Burghoff (326507), Florian Bönner (326503)   +3 more
core   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Hematology/Oncology and Stem Cell Therapy, 2019
Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune ...
Eman Mosaad Zaki, Asmaa Mohamed Zahran, Alshimaa Abdelazeem Metwaly, Rania Hafez, Safinaz Hussein, Abdallah Elaiw Mohammed   +5 more
doaj   +1 more source

High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer

Journal for ImmunoTherapy of Cancer, 2021
Background Hydrolysis of extracellular ATP to adenosine (eADO) is an important immune checkpoint in cancer immunology. We here investigated the impact of the eADO pathway in high-grade serous ovarian cancer (HGSC) using multiparametric platforms.Methods ...
John Stagg, Anne-Marie Mes-Masson, Rejean Lapointe, Pamela Thebault, David Allard, Isabelle Cousineau, Yacine Bareche, Sandra Pommey, Mayra Carneiro, Laurence Buisseret, Pavel Chrobak, Laudine Communal, Simon C Robson, Diane Provencher   +13 more
doaj   +1 more source

Targeting CD39 in cancer reveals an extracellular ATP- and inflammasome-driven tumor immunity

, 2019
We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39 conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP-P2-mediated proinflammatory responses.
Robson, Simon C., Alana G. Lerner, Beers, Courtney, Welch, Megan, Jason Madore, Amelia Roman Aguilera, Smyth, Mark J, Tracy dela Cruz, Spatola, Bradley N, Lerner, Alana G., Kyohei Nakamura, Christos Xiao, Rebecca L. Johnston, Xian-Yang Li, Corbin, John, Maike Effern, Bald, Tobias, John Corbin, Clifford Wong, Johnston, Rebecca L, Soros, Vanessa B., Spatola, Bradley N., Nicola Waddell, Bradley N. Spatola, Li, Xian-Yang, Xiao, Christos, Lerner, Alana G, Tobias Bald, Courtney Beers, Haiyan Zhang, Sundarrajan, Ashmitha, Wong, Clifford, Teng, Michele WL, Vanessa B. Soros, Lepletier, Ailin, Megan Welch, Soros, Vanessa B, Geetha, Nishamol, Aguilera, Amelia Roman, Anderson, Ana C., Simon C. Robson, Smith, Corey, Johnston, Rebecca L., Anderson, Ana C, Ana C. Anderson, Ailin Lepletier, Madore, Jason, Moesta, Achim K, Robson, Simon C, Effern, Maike, Achim K. Moesta, Michael Hölzel, Mika Casey, Teng, Michele W L, Ashmitha Sundarrajan, Hölzel, Michael, Dela Cruz, Tracy, Waddell, Nicola, Jacoberger-Foissac, Celia, Corey Smith, Hoelzel, Michael, Celia Jacoberger-Foissac, Zhang, Haiyan, Mark J. Smyth, Moesta, Achim K., Nishamol Geetha, Nakamura, Kyohei, Michele W. L. Teng, Smyth, Mark J., Casey, Mika   +69 more
core   +1 more source