Results 71 to 80 of about 33,325 (191)

Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms

The Journal of Dermatology, EarlyView.
ABSTRACT γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework ...
Simo Du, Anika Jallorina, Toru Yoshino, Lingyu Bao, Han Bao, Victor Chang, Henry K. Wong, Derek V. Chan, Stephen K. Richardson, Mary F. Lee‐Wong   +9 more
wiley   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Hepatic Arachidonic Acid Dysregulation Impairs Double-Negative Regulatory T Cell-Mediated Immunoregulation via CD39 Downregulation and Drives MASLD Development

Journal of Immunology Research
Immune dysregulation is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Double-negative regulatory T (DNT) cells, which are essential for hepatic immune homeostasis, are functionally impaired in MASLD.
Hua Jin, Xiyu Wang, Xinjuan Liu, Dong Zhang, Guangyong Sun   +4 more
doaj   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

CD39-adenosinergic axis in renal pathophysiology and therapeutics

, 2018
© 2018, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions.
SC Robson (14541245), KM Dwyer (14448135), BK Kishore (14541434)   +2 more
core  

Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis

, 2008
Concanavalin A (Con A)-induced injury is an established natural killer T (NKT) cell-mediated model of inflammation that has been used in studies of immune liver disease.
Robson, Simon C., Beldi, Guido, Enjyoji, Keiichi, Yegutkin, Gennady G, Simon C. Robson, Michael Nowak, Banz, Yara, Candinas, Daniel, Yan Wu, Lindsay Miller, Miller, Lindsay, Guido Beldi, Keiichi Enjyoji, Arvand Haschemi, Yegutkin, Gennady G., Wu, Yan, Robson, Simon C, Nowak, Michael, Exley, Mark, Haschemi, Arvand, Daniel Candinas, Yara Banz, Gennady G. Yegutkin, Mark Exley   +23 more
core   +1 more source

Variable Impact of CD39 in Experimental Murine Colitis.

, 2011
Dysregulation of immune responses in inflammatory bowel diseases (IBD) results in intestinal inflammation and vascular injury while exacerbating systemic disease.
Künzli, BM;Berberat, PO;Dwyer, K;Deaglio, S;Csizmadia, E;Cowan, P;d'Apice, A;Moore, G;Enjyoji, K;Friess, H;Robson, SC
core   +2 more sources

CD25+CD134+ CD39+FoxP3+ cells have bona fide Tregs phenotype.

, 2018
(A) Gating strategy used for detecting CMV-specific CD4+CD25+CD134+ CD39+FoxP3+ Tregs, and IFN-γ producing CD25+CD134+CD39-FoxP3- and CD25+CD134+ CD39-FoxP3+. PBMCs from CMV+ individuals were stimulated with CMV lysate for 44hrs.
Yves Levy (119516), Jean-Daniel Lelièvre (3173220), Vedran Brezar (337452), Nabila Seddiki (214661), Christine Lacabaratz (567696), Lylia Hani (4249249), Mathieu Surenaud (78141), Audrey Hubert (4249252)   +7 more
core   +1 more source

Genetic Engineering of Tumor‐Infiltrating Lymphocytes (TIL) via a T‐Editor Platform to Enhance Anti‐Tumor Activity

Cancer Science, EarlyView.
A rapid and efficient CRISPR‐mediated gene editing platform for TIL engineering identified FAM84B as a novel potential target to enhance antitumor activity and pioneered the use of CBE to generate FAM84B loss‐of‐function TIL with enhanced antitumor activity.
Fenge Li, Xuejiao Ma, Yongming Xue, Jilong Yang, Ruijing Wang, Xiang Li, Chao Zhang, Wenhan Lu, Mei Liu, Yue Xu, Xinyi Wang, Shengnan Wu, Ning Kang, Chunhua Ma   +13 more
wiley   +1 more source

Ruolo di due ectoenzimi, CD39 e CD73, nella modulazione dei processi infiammatori nel ratto

, 2008
La manipolazione del decorso e dell'intensità di un processo infiammatorio può avvenire non solo impiegando agenti che inibiscano le "pathways proinfiammatorie" attivate, ma anche mediante un approccio volto ad attivare i processi antinfiammatori ...
CICALA, CARLA
core