Results 31 to 40 of about 34,165 (229)

A gut feeling for CD39 [PDF]

Science-Business eXchange, 2009
American and German researchers have reported that enhancing CD39 activity in the gut could help treat inflammatory bowel disease. The researchers are now developing a soluble form of CD39 that they hope could become an infusible therapeutic to treat colitis and Crohn's disease.
openaire   +1 more source

Regulation of the T Cell Response by CD39 [PDF]

Trends in Immunology, 2016
The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine.
Maisa C, Takenaka, Simon, Robson, Francisco J, Quintana   +2 more
openaire   +2 more sources

Functionally impaired CD103+CD39+CD8+ T cell subsets with immune-suppressive properties infiltrating gastric cancer tissues promote tumor progression

陆军军医大学学报
Objective To detect the infiltration level of CD103+CD39+CD8+ T cell subsets in gastric cancer tissues and analyze their response characteristics, clarifying the clinical relevance of this subset.
HUANG Mengqiu, ZHONG Hang
doaj   +1 more source

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. [PDF]

PLoS Neglected Tropical Diseases, 2013
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
Fabio E Leal, Lishomwa C Ndhlovu, Aaron M Hasenkrug, Fernanda R Bruno, Karina I Carvalho, Harry Wynn-Williams, Walter K Neto, Sabri S Sanabani, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas   +10 more
doaj   +1 more source

Reduced Ki67 expression in CD4⁺CD39⁺ T cells following CD39 blocking.

, 2018
PBMC from microfilaremic (Fil+) and uninfected (Fil-) subjects were stained for intracellular Ki67, an indicator of T-cell proliferation. We first compared the proportion of Ki67+ cells among CD4+CD39+ and CD4+CD39- T cells (panel A) and CD39+ and CD39 ...
Marcelo U. Ferreira (138475), Raquel M. Gonçalves-Lopes (4288384), Nathália F. Lima (622805), Maria Yazdanbakhsh (90295), Yvonne C. M. Kruize (90288)   +4 more
core   +1 more source

Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity

Frontiers in Oncology, 2020
The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-induced ...
Alina V. Meyer, Diana Klein, Simone de Leve, Klaudia Szymonowicz, Martin Stuschke, Simon C. Robson, Verena Jendrossek, Florian Wirsdörfer   +7 more
doaj   +1 more source

CD25+CD134+ CD39+FoxP3+ cells have bona fide Tregs phenotype.

, 2018
(A) Gating strategy used for detecting CMV-specific CD4+CD25+CD134+ CD39+FoxP3+ Tregs, and IFN-γ producing CD25+CD134+CD39-FoxP3- and CD25+CD134+ CD39-FoxP3+. PBMCs from CMV+ individuals were stimulated with CMV lysate for 44hrs.
Yves Levy (119516), Jean-Daniel Lelièvre (3173220), Vedran Brezar (337452), Nabila Seddiki (214661), Christine Lacabaratz (567696), Lylia Hani (4249249), Mathieu Surenaud (78141), Audrey Hubert (4249252)   +7 more
core   +1 more source

Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity

Journal for ImmunoTherapy of Cancer, 2019
Background Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP to adenosine ...
Abhishek S. Kashyap, Tamara Thelemann, Richard Klar, Sandra M. Kallert, Julia Festag, Melanie Buchi, Lisa Hinterwimmer, Monika Schell, Sven Michel, Frank Jaschinski, Alfred Zippelius   +10 more
doaj   +1 more source

A Novel Prognostic Biomarker of Luminal Breast Cancer: High CD39 Expression Is Related to Poor Survival

Frontiers in Genetics, 2021
BackgroundCD39 is one of the functional surface markers for T regulatory cells, the prognostic role and immune-related effects of CD39 in luminal breast cancer (BC) patients has not been evaluated yet.
Xiaojian Ni, Xiaojian Ni, Wenze Wan, Wenze Wan, Jingjing Ma, Xinyou Liu, Bohao Zheng, Bohao Zheng, Zhixian He, Weige Yang, Weige Yang, Weige Yang, Lihong Huang, Lihong Huang   +13 more
doaj   +1 more source

Deletion of CD39 inhibits development of metastatic liver cancer

, 2007
New vessel formation and tumor infiltrating lymphocytes (TIL) influence host responses to malignant tissues. Extracellular adenosine-mediated pathways promote both vascular endothelial cell proliferation and inhibit cytotoxic T cells, thereby ...
Sun, Xiaofeng, Beldi, Guido, Wu, Yon, Robson, Simon C, Enjoyji, Keiichi, Ogawa, Mika, Csizmadia, Eva, Fung, JYY, Tanaka, Y, Yuen, RMF, Gressner, Axel M., But, D, Fong, DYT, Yuen, JCH, Wong, DKH, Fung, FKC, Mizokami, M, Weiskirchen, Ralf, Cheung, TK, Hung, IFN, Vreden, Wanda N., Young, JLP, Lai, CL, Lin, EY;Chen, YC;Huang, SF;Yeh, CT;Liaw, YF, Scherner, Olaf Andreas, Meurer, Steffen K.   +25 more
core   +1 more source