Results 31 to 40 of about 28,618 (205)
Regulation of the T Cell Response by CD39 [PDF]
Trends in Immunology, 2016 The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine.
Maisa C, Takenaka +2 more
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Biomedicines, 2021 Asthma is a chronic respiratory inflammatory disease. Patients usually suffer long-term symptoms and high medical expenses. Extracellular ATP (eATP) has been identified as a danger signal in innate immunity and serves as a potent inflammatory mediator ...
Yung-An Huang +6 more
doaj +1 more source
Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. [PDF]
PLoS Neglected Tropical Diseases, 2013 HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
Fabio E Leal +10 more
doaj +1 more source
Frontiers in Oncology, 2020 The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-induced ...
Alina V. Meyer +7 more
doaj +1 more source
Frontiers in Genetics, 2021 BackgroundCD39 is one of the functional surface markers for T regulatory cells, the prognostic role and immune-related effects of CD39 in luminal breast cancer (BC) patients has not been evaluated yet.
Xiaojian Ni +13 more
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Journal of Animal Reproduction and Biotechnology, 2018 Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No +10 more
doaj +1 more source
Science-Business eXchange, 2009 American and German researchers have reported that enhancing CD39 activity in the gut could help treat inflammatory bowel disease. The researchers are now developing a soluble form of CD39 that they hope could become an infusible therapeutic to treat colitis and Crohn's disease.
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A humanized monoclonal antibody targeting CD39 with novel mechanism for cancer treatment
Medicine in Drug Discovery, 2021 ATP-adenosine signal axis plays an import role in tumor immune regulation. ATP released by tumor cells can promote antitumor immunity, and adenosine can suppress the immune response.
Zheng Wei +5 more
doaj +1 more source
Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]
PLoS ONE, 2016 T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández +17 more
doaj +1 more source
Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase [PDF]
Journal of Biological Chemistry, 1996 Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP. Analysis of amino acid sequences available from various mammalian and avian ATPDases revealed their close homology with CD39, a putative B-cell activation marker.
E, Kaczmarek +7 more
openaire +2 more sources