Results 31 to 40 of about 33,325 (191)
Low expression of CD39 and CD73 genes in centenarians compared with octogenarians [PDF]
, 2017 Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells.
Alfonso Cruz-Jentoft +17 more
core +1 more source
, 2020 The ATP–adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumour microenvironment. Consequently, multiple clinical strategies are being explored to target this pathway for the treatment of cancer; in particular ...
Moesta, Achim K. +5 more
core +1 more source
Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity
Journal for ImmunoTherapy of Cancer, 2019 Background Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP to adenosine ...
Abhishek S. Kashyap +10 more
doaj +1 more source
Frontiers in Genetics, 2021 BackgroundCD39 is one of the functional surface markers for T regulatory cells, the prognostic role and immune-related effects of CD39 in luminal breast cancer (BC) patients has not been evaluated yet.
Xiaojian Ni +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2019 (A) Determination of CD39 activity in cell membranes using three different cell lines, Farage cell (solid circle) has the highest CD39 activity using ATP as substrate.
Said A. Goueli (7548320) +1 more
core +1 more source
Cell Reports MedicineSummary: CD39+CD8+ T cells are known as tumor-antigen-specific cells among CD8+ tumor-infiltrating lymphocytes (TILs). However, CD39+CD8+ T cells also reportedly exhibit immunosuppressive activity in hypoxic tumor models.
Yong Joon Lee +22 more
doaj +1 more source
Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]
PLoS ONE, 2016 T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández +17 more
doaj +1 more source
Advanced Science, EarlyView.ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang +9 more
wiley +1 more source