Results 11 to 20 of about 34,165 (229)

Assessment of CD4⁺ cells subpopulations with the expressing CD39 and CD73 ectonucleotidases in children with psoriasis

Медицинская иммунология, 2022
Purinergic signaling modulates systemic and local inflammatory responses in immune-mediated and autoimmune diseases, including psoriasis. Extracellular ATP is an important factor of purinergic regulation, and its levels are regulated by catalytic effects
D. G. Kuptsova, T. V. Radigina, S. V. Petrichuk, N. N. Murashkin, A. A. Khotko, R. A. Ivanov   +5 more
doaj   +2 more sources

CD39/Adenosine Pathway Is Involved in AIDS Progression. [PDF]

PLoS Pathogens, 2011
International audienceHIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions.
Younas, Mehwish, Mohammad-Ali Jenabian, Zagury, Jean-François, Anne Hulin, Nikolova, M., Mullins, J.I., Lévy, Yves, Hue, S., Joshua T. Herbeck, Mehwish Younas, Muhtarova, Maria, Sophie Limou, Sophie Huë, Lelievre, J.D., Joshua T Herbeck, James I Mullins, Limou, S., Armand Bensussan, Jenabian, Mohammad-Ali, Jean-Daniel Lelievre, Nikolova, Maria, Herbeck, Joshua,, Olivier Delaneau, Carriere, M., Muhtarova, M., Koek, A., Carriere, Matthieu, Bensussan, A., James I. Mullins, Schuitemaker, H., Zagury, J.F., Hanneke Schuitemaker, Huë, Sophie, Ayrin Kök, Nabila Seddiki, Delaneau, O., Younas, M., Matthieu Carriere, Lelievre, Jean-Daniel, Levy, Y., Schuitemaker, Hanneke, Mullins, James, I., Kök, Ayrin, Mullins, James,, Seddiki, N., Hulin, A., Maria Nikolova, Yves Lévy, Bensussan, Armand, Jenabian, M.A., Maria Muhtarova, Limou, Sophie, Delaneau, Olivier, Seddiki, Nabila, Jean-François Zagury, Herbeck, J.T., Hulin, Anne, Herbeck, Joshua, T., Muhtarova Maria, Limou Sophie, Carriere, M, Delaneau, O, Nikolova Maria, Nikolova, M, Seddiki, N, Jenabian Mohammad-Ali, Lelievre Jean-Daniel, Zagury Jean-François, Mullins, JI, Younas, M, Delaneau Olivier, Seddiki Nabila, Herbeck, JT, Carriere Matthieu, Kök, A, Kök Ayrin, Huë Sophie, Limou, S, Jenabian, MA, Hulin Anne, Schuitemaker, H, Schuitemaker Hanneke, Younas Mehwish, Hulin, A, Lévy Yves, Lévy, Y, Herbeck Joshua T., Huë, S, Bensussan Armand, Mullins James I.   +89 more
core   +11 more sources

Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response [PDF]

Biomolecules, 2023
In rheumatoid arthritis (RA) synovium, ATP, and ADP are released, sparking inflammation. Ectoenzymes CD39 and CD73 metabolize these purine nucleotides, generating anti-inflammatory adenosine. Therefore, dysregulated CD39 and CD73 expression may impact RA
María Angels Ortiz, Cesar Diaz-Torné, Juan Jose De Agustin, Paula Estrada, Delia Reina, María Victoria Hernandez, Hye Sang, Carlos Zamora, Elisabet Cantó, Hector Corominas, Silvia Vidal   +10 more
doaj   +2 more sources

Review immune response of targeting CD39 in cancer

Biomarker Research, 2023
The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD73 and the adenosine receptors A2AR or A2BR ...
Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen, Ligong Lu   +7 more
doaj   +3 more sources

Thrombo-Inflammation: A Focus on NTPDase1/CD39 [PDF]

Cells, 2021
There is increasing evidence for a link between inflammation and thrombosis. Following tissue injury, vascular endothelium becomes activated, losing its antithrombotic properties whereas inflammatory mediators build up a prothrombotic environment.
Morello, Silvana, Caiazzo, Elisabetta, Turiello, Roberta, Cicala, Carla   +3 more
openaire   +5 more sources

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti-PD-1 Therapy. [PDF]

Adv Sci (Weinh)
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Wang J, Tang X, Li Z, Qi Q, Sun C, Sun W, Zhang W, Yin Y, Deng Y, Ling P, Xu Y, Sun G, Ren Y, Pan H, Wang S, Zhou W.   +15 more
europepmc   +2 more sources

CD39 and CD73 in immunity and inflammation [PDF]

Trends in Molecular Medicine, 2013
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, respectively. This drives a shift from an ATP-driven proinflammatory environment to an anti-inflammatory milieu induced ...
ANTONIOLI, LUCA, Pacher, P, Vizi, Es, Haskó, G.   +3 more
openaire   +3 more sources

CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

OncoImmunology, 2023
Conventional CD4+ T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood.
Sabrina N. Bossio, Carolina Abrate, Jimena Tosello Boari, Constanza Rodriguez, Fernando P. Canale, María C. Ramello, Valentina Brunotto, Wilfrid Richer, Dario Rocha, Christine Sedlik, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Elmer Fernandez, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes   +17 more
doaj   +1 more source

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Background An important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A2A and A2B receptors on immune cells constituting one of the strongest ...
Julie Pelletier, Jean Sévigny, Laura Schäkel, Salahuddin Mirza, Riekje Winzer, Vittoria Lopez, Riham Idris, Haneen Al-Hroub, Eva Tolosa, Christa E Müller   +9 more
doaj   +1 more source

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. [PDF]

, 2011
Vaccination with Bacille Calmette-Guérin (BCG) has traditionally been used for protection against disease caused by the bacterium Mycobacterium tuberculosis (M.tb). The efficacy of BCG, especially against pulmonary tuberculosis (TB) is variable. The best
Minassian, Angela M, Pathan, Ansar A, Sander Clare R., Helen A. Fletcher, Fletcher, Helen A, Natalie E R Beveridge, Hill, AVS, Minassian Angela M., Angela M Minassian, Fletcher, HA, Kristin L. Griffiths, Pathan Ansar A., Kristin L Griffiths, Hill, Adrian VS, Griffiths Kristin L., Sander, CR, Hill Adrian V. S., McShane Helen, Beveridge Natalie E. R., Pathan, AA, Minassian, AM, Clare R. Sander, Ansar A. Pathan, Griffiths, KL, Beveridge, NER, Clare R Sander, Helen McShane, Ansar A Pathan, Natalie E. R. Beveridge, Griffiths, Kristin L, Sander, Clare R, Adrian V S Hill, Adrian V. S. Hill, Helen A Fletcher, Fletcher Helen A., Beveridge, Natalie ER, McShane, H, Angela M. Minassian, McShane, Helen   +38 more
core   +1 more source