Results 21 to 30 of about 31,390 (228)
Journal for ImmunoTherapy of Cancer, 2022 Background An important mechanism, by which cancer cells achieve immune escape, is the release of extracellular adenosine into their microenvironment. Adenosine activates adenosine A2A and A2B receptors on immune cells constituting one of the strongest ...
Julie Pelletier +9 more
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CD39 Is an Ecto-(Ca2+,Mg2+)-apyrase [PDF]
Journal of Biological Chemistry, 1996 CD39, a 70- to 100-kDa molecule expressed primarily on activated lymphoid cells, was previously identified as a surface marker of Epstein Barr virus (EBV)-transformed B cells. In this report, we show that an ecto-(Ca2+,Mg2+)-apyrase activity is present on EBV-transformed B cells, but not on B or T lymphomas.
T F, Wang, G, Guidotti
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CD39 – A bright target for cancer immunotherapy
Biomedicine & Pharmacotherapy, 2022 The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumor microenvironment, and cancer immune evasion largely involves the generation of high amounts of immunosuppressive extracellular adenosine (eADO). Consequently, inhibition of eADO-generating enzymes and/or eADO receptors can effectively restore the ...
Shuwei, Guo, Fengfeng, Han, Wei, Zhu
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Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. [PDF]
, 2011 Vaccination with Bacille Calmette-Guérin (BCG) has traditionally been used for protection against disease caused by the bacterium Mycobacterium tuberculosis (M.tb). The efficacy of BCG, especially against pulmonary tuberculosis (TB) is variable. The best
Minassian, Angela M +43 more
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Deletion of CD39 inhibits development of metastatic liver cancer [PDF]
, 2007 New vessel formation and tumor infiltrating lymphocytes (TIL) influence host responses to malignant tissues. Extracellular adenosine-mediated pathways promote both vascular endothelial cell proliferation and inhibit cytotoxic T cells, thereby ...
Sun, Xiaofeng +6 more
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Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis [PDF]
, 2009 Radiation proctitis is an inflammatory process associated with persistent and refractory lower gastrointestinal bleeding. Purinergic signaling regulates hemostasis, inflammation, and angiogenesis.
Chandrashekhar Thukral +13 more
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Human Vaccines & Immunotherapeutics, 2018 The field of immunotherapeutics is living an exceptional time as new antibodies that take brakes off T-cells and unleash them on tumours are being approved by the US-Food and Drug Administration (FDA).
Audrey Hubert, Nabila Seddiki
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Trakya University Journal of Natural Sciences, 2022 The aim of this study is to characterize tumor cell specific expression of purinergic ecto-enzymes CD39 and CD73, and to associate prognostic significance of these expression patterns in colorectal cancer (CRC) patients.
Serkan Göktuna
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Regulation of the T Cell Response by CD39 [PDF]
Trends in Immunology, 2016 The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine.
Maisa C, Takenaka +2 more
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Determination of membrane bound CD39 enzyme activity and CD39 inhibitor potency on membrane associated CD39 activity. [PDF]
, 2019 (A) Determination of CD39 activity in cell membranes using three different cell lines, Farage cell (solid circle) has the highest CD39 activity using ATP as substrate.
Said A. Goueli (7548320) +1 more
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