Results 21 to 30 of about 34,165 (229)
Trakya University Journal of Natural Sciences, 2022 The aim of this study is to characterize tumor cell specific expression of purinergic ecto-enzymes CD39 and CD73, and to associate prognostic significance of these expression patterns in colorectal cancer (CRC) patients.
Serkan Göktuna
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Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis [PDF]
, 2009 Radiation proctitis is an inflammatory process associated with persistent and refractory lower gastrointestinal bleeding. Purinergic signaling regulates hemostasis, inflammation, and angiogenesis.
Chandrashekhar Thukral +13 more
core +2 more sources
Human Vaccines & Immunotherapeutics, 2018 The field of immunotherapeutics is living an exceptional time as new antibodies that take brakes off T-cells and unleash them on tumours are being approved by the US-Food and Drug Administration (FDA).
Audrey Hubert, Nabila Seddiki
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Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions
, 2020 In our study, we investigated the role of CD39 on tumor-infiltrating CD8(+)T lymphocytes (CD8(+)TILs) in colorectal, head and neck and pancreatic cancers. Partially confirming recent observations correlating the CD39 expression with T-cell exhaustion, we
Lancellotti F. +30 more
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Медицинская иммунология, 2023 MS is a common disease of the central nervous system that leads to disability and reduced quality of life. The debut of disease in 3-5% of patients occurs in childhood and has a less favorable course compared to adults.
T. V. Radygina +7 more
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CD39 Is an Ecto-(Ca2+,Mg2+)-apyrase [PDF]
Journal of Biological Chemistry, 1996 CD39, a 70- to 100-kDa molecule expressed primarily on activated lymphoid cells, was previously identified as a surface marker of Epstein Barr virus (EBV)-transformed B cells. In this report, we show that an ecto-(Ca2+,Mg2+)-apyrase activity is present on EBV-transformed B cells, but not on B or T lymphomas.
T F, Wang, G, Guidotti
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CD39 – A bright target for cancer immunotherapy
Biomedicine & Pharmacotherapy, 2022 The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumor microenvironment, and cancer immune evasion largely involves the generation of high amounts of immunosuppressive extracellular adenosine (eADO). Consequently, inhibition of eADO-generating enzymes and/or eADO receptors can effectively restore the ...
Shuwei, Guo, Fengfeng, Han, Wei, Zhu
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Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors [PDF]
Frontiers in Pharmacology, 2020 Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP, which can be further hydrolyzed by ecto-5'-nucleotidase (CD73) to immunosuppressive, cancer-promoting adenosine ...
Laura Schäkel +12 more
openaire +3 more sources
Journal of Animal Reproduction and Biotechnology, 2018 Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No +10 more
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Biomedicines, 2021 Asthma is a chronic respiratory inflammatory disease. Patients usually suffer long-term symptoms and high medical expenses. Extracellular ATP (eATP) has been identified as a danger signal in innate immunity and serves as a potent inflammatory mediator ...
Yung-An Huang +6 more
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