Results 21 to 30 of about 33,325 (191)

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC   +11 more
core   +1 more source

Development of aortic endothelial cells to express CD37 and CD73 isolated from alpha 1,3-galactosyltransferase knock-out and MCP expressing pig

Journal of Animal Reproduction and Biotechnology, 2018
Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No, Sung-June Byun, Hyeon Yang, Sun A Ock, Jae-Seok Woo, Hwi-Cheul Lee, In-sul Hwang, Ji-Youn Kim, Sang Hyoun Park, Joo Young Lee, Keon Bong Oh   +10 more
doaj   +1 more source

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer [PDF]

, 2011
Despite improvements in prevention and management of colorectal cancer (CRC), uncontrolled tumor growth with metastatic spread to distant organs remains an important clinical concern.
Robson, Simon C., Simon C. Robson, Maria-Isabell Bernlochner, Käser, Samuel, Dwyer, Karen, Maurer, Christoph A., Samuel Käser, Csizmadia, Eva, Rath, Stephan, Beat M. Künzli, Robson, Simon C, Helmut Friess, Aurel Perren, Cowan, Peter, Perren, Aurel, Rosenberg, Robert, Enjyoji, Keiichi, Stephan Rath, Christoph A. Maurer, Künzli, Beat M., Bernlochner, Maria-Isabell, Friess, Helmut, Keiichi Enjyoji, Eva Csizmadia, d'Apice, Anthony, Peter Cowan, Robert Rosenberg, Anthony d’Apice, Maurer, Christoph A, Karen Dwyer, Künzli, Beat M   +30 more
core   +2 more sources

Reducing Lung ATP Levels and Alleviating Asthmatic Airway Inflammation through Adeno-Associated Viral Vector-Mediated CD39 Expression

Biomedicines, 2021
Asthma is a chronic respiratory inflammatory disease. Patients usually suffer long-term symptoms and high medical expenses. Extracellular ATP (eATP) has been identified as a danger signal in innate immunity and serves as a potent inflammatory mediator ...
Yung-An Huang, Jeng-Chang Chen, Chih-Ching Wu, Chia-Wei Hsu, Albert Min-Shan Ko, Li-Chen Chen, Ming-Ling Kuo   +6 more
doaj   +1 more source

Review immune response of targeting CD39 in cancer

Biomarker Research, 2023
The ATP-adenosine pathway has emerged as a promising target for cancer therapy, but challenges remain in achieving effective tumor control. Early research focused on blocking the adenosine generating enzyme CD73 and the adenosine receptors A2AR or A2BR ...
Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen, Ligong Lu   +7 more
doaj   +1 more source

What Else Can CD39 Tell Us? [PDF]

, 2017
As the rate-limiting enzyme in ATP/ADP–AMP–adenosine pathway, CD39 would be a novel checkpoint inhibitor target in preventing adenosine-triggered immune-suppressive effect.
Cong Bo, Hong Li, Hai Zhao, Yan Kang
core   +1 more source

Functionally impaired CD103+CD39+CD8+ T cell subsets with immune-suppressive properties infiltrating gastric cancer tissues promote tumor progression

陆军军医大学学报
Objective To detect the infiltration level of CD103+CD39+CD8+ T cell subsets in gastric cancer tissues and analyze their response characteristics, clarifying the clinical relevance of this subset.
HUANG Mengqiu, ZHONG Hang
doaj   +1 more source

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. [PDF]

PLoS Neglected Tropical Diseases, 2013
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
Fabio E Leal, Lishomwa C Ndhlovu, Aaron M Hasenkrug, Fernanda R Bruno, Karina I Carvalho, Harry Wynn-Williams, Walter K Neto, Sabri S Sanabani, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas   +10 more
doaj   +1 more source

Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity

Frontiers in Oncology, 2020
The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-induced ...
Alina V. Meyer, Diana Klein, Simone de Leve, Klaudia Szymonowicz, Martin Stuschke, Simon C. Robson, Verena Jendrossek, Florian Wirsdörfer   +7 more
doaj   +1 more source

Deletion of CD39 inhibits development of metastatic liver cancer

, 2007
New vessel formation and tumor infiltrating lymphocytes (TIL) influence host responses to malignant tissues. Extracellular adenosine-mediated pathways promote both vascular endothelial cell proliferation and inhibit cytotoxic T cells, thereby ...
Sun, Xiaofeng, Beldi, Guido, Wu, Yon, Robson, Simon C, Enjoyji, Keiichi, Ogawa, Mika, Csizmadia, Eva   +6 more
core   +1 more source