Results 21 to 30 of about 932,452 (224)
Purinergic signaling in the airways
Pharmacological Reviews, 2012 : Evidence for a significant role and impact of purinergic signaling in normal and diseased airways is now beyond dispute. The present review intends to provide the current state of knowledge of the involvement of purinergic pathways in the upper and ...
Burnstock, Geoffrey +7 more
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Perturbing purinergic signaling: A pathogen's guidebook to counteracting inflammatory responses
Biomedical Journal, 2016 In this issue of the Biomedical Journal, we learn how bacteria and parasites alike counteract inflammatory signaling by manipulating purinergic signaling.
Emma L. Walton
doaj +2 more sources
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 The concept of purinergic neurotransmission was proposed in 1972, after it was shown that adenosine 5′-triphosphate (ATP) was a transmitter in non-adrenergic, non-cholinergic inhibitory nerves in the guinea pig taenia coli.
Burnstock, G., Verkhratsky, A.; id_orcid
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Purinergic signaling in atherosclerosis
Trends in Molecular Medicine, 2015 Cell surface expression of specific receptors and ectonucleotidases makes extracellular nucleotides such as ATP, ADP, UTP, and adenosine suitable as signaling molecules for physiological and pathological events, including tissue stress and damage. Recent
Idzko M +6 more
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Purinergic signaling in scarring
The FASEB Journal, 2016 Adenosine (ADO) and nucleotides such as ATP, ADP, and uridine 5′-triphosphate (UTP), among others, may serve as extracellular signaling molecules. These mediators activate specific cell-surface receptors - namely, purinergic 1 and 2 (P1 and P2) - to ...
Robson, Simon C. +10 more
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Purinergic Regulation of Neutrophil Function
Frontiers in Immunology, 2018 Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen
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Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells [PDF]
Frontiers in Endocrinology, 2020 The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel +3 more
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Purinergic signaling and microglia
Pflügers Archiv - European Journal of Physiology, 2006 Microglial cells are considered as the pathologic sensors of the brain. In this paper, we review mechanisms of purinergic signaling in microglia. As ATP is not only considered as a physiological signaling substance but is also elevated in pathology, it ...
Kettenmann, H., Faerber, K.
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Purinergic and Calcium Signaling in Macrophage Function and Plasticity [PDF]
Frontiers in Immunology, 2014 In addition to a fundamental role in cellular bioenergetics, the purine nucleotide adenosine triphosphate (ATP) plays a crucial role in the extracellular space as a signaling molecule.
Bimal N Desai, Norbert eLeitinger
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Purinergic signaling during Porphyromonas gingivalis infection [PDF]
Biomedical Journal, 2016 Despite recent advances unraveling mechanisms of hostâpathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions.
Cássio Luiz Coutinho Almeida-da-Silva +4 more
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