Results 21 to 30 of about 842,442 (245)

Delineating Purinergic Signaling in Drosophila

International Journal of Molecular Sciences, 2022
Simplistic models can aid in discovering what is important in the context of normal and pathological behavior. First recognized as a genetic model more than 100 years ago, to date, fruit flies (Drosophila melanogaster) still remain an astonishingly good ...
Alberti, Francesca, Giuseppe Vitale, Liguori, Francesco, Cinzia Volonté, Vitale, Giuseppe, Volonté, Cinzia, Francesco Liguori, Francesca Alberti   +7 more
core   +3 more sources

Purinergic signaling in atherosclerosis

Trends in Molecular Medicine, 2015
Cell surface expression of specific receptors and ectonucleotidases makes extracellular nucleotides such as ATP, ADP, UTP, and adenosine suitable as signaling molecules for physiological and pathological events, including tissue stress and damage. Recent
Idzko M, la Sala A., Vitiello L, FERRARI, Davide   +3 more
core   +5 more sources

Dissecting the Purinergic Signaling Puzzle

International Journal of Molecular Sciences, 2021
Purinergic signaling regulates a plethora of physiological processes and is an expanding research field [...
Raquel Pérez-Sen, Delicado, Esmerilda G, Esmerilda G. Delicado, Pérez-Sen, Raquel   +3 more
core   +5 more sources

Purinergic signaling in the airways

Pharmacological Reviews, 2012
: Evidence for a significant role and impact of purinergic signaling in normal and diseased airways is now beyond dispute. The present review intends to provide the current state of knowledge of the involvement of purinergic pathways in the upper and ...
Burnstock, Geoffrey, Geoffrey Burnstock, Dirk Adriaensen, Timmermans, Jean-Pierre, Brouns, Inge, Jean-Pierre Timmermans, Adriaensen, Dirk, Inge Brouns   +7 more
core   +4 more sources

Purinergic signaling in the cerebellum

, 2023
Purinergic signaling is a complex and evolutionarily conserved mechanism of extracellular communication involved in many physiological and pathological functions.
Wall, Mark J.
core   +2 more sources

Purinergic signaling and microglia

Pflügers Archiv - European Journal of Physiology, 2006
Microglial cells are considered as the pathologic sensors of the brain. In this paper, we review mechanisms of purinergic signaling in microglia. As ATP is not only considered as a physiological signaling substance but is also elevated in pathology, it ...
Kettenmann, H., Faerber, K.
core   +3 more sources

Purinergic signaling in kidney disease [PDF]

Kidney International, 2016
Nucleotides are key subunits for nucleic acids and provide energy for intracellular metabolism. They can also be released from cells to act physiologically as extracellular messengers or pathologically as danger signals.
Unwin, RJ, Tam, Frederick W K, Unwin, Robert J, Tam, FW, Menzies, RI, Menzies, Robert, Tam, FWK, Bailey, Matthew; id_orcid, Bailey, MA   +8 more
core   +6 more sources

Purinergic signaling

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
The concept of purinergic neurotransmission was proposed in 1972, after it was shown that adenosine 5′-triphosphate (ATP) was a transmitter in non-adrenergic, non-cholinergic inhibitory nerves in the guinea pig taenia coli.
Burnstock, G., Verkhratsky, A.; id_orcid
core   +3 more sources

In Memoriam Geoffrey Burnstock: Creator of Purinergic Signaling

Function, 2020
Geoff Burnstock (1929–2020) discovered purinergic signaling in a fastidious research that started in early 1960 and culminated in a concept of purinergic nerves in 1972.
Alexei Verkhratsky, Herbert Zimmermann, Maria P Abbracchio, Peter Illes, Francesco DiVirgilio   +4 more
doaj   +3 more sources

Purinergic and Calcium Signaling in Macrophage Function and Plasticity [PDF]

Frontiers in Immunology, 2014
In addition to a fundamental role in cellular bioenergetics, the purine nucleotide adenosine triphosphate (ATP) plays a crucial role in the extracellular space as a signaling molecule.
Bimal N Desai, Norbert eLeitinger
doaj   +2 more sources