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Cytolytic P2X purinoceptors [PDF]

Cell Death & Differentiation, 1998
Anecdoctal evidence accumulated over almost 20 years has shown that many different cell types are killed by sustained exposure to high concentrations of extracellular ATP. The plasma membrane receptors involved have been pharmacologically characterized and cloned during the last 3 years, and named purinergic P2X.
DI VIRGILIO, Francesco, CHIOZZI, Paola, FALZONI, Simonetta, FERRARI, Davide, SANZ MOLINA, Juana Maria, VENKETARAMAN V, BARICORDI, Olavio   +6 more
openaire   +3 more sources

Transcriptome and metabolome profiling uncover phenotypic divergence of gigantic and dwarf mutant genotypes in induced Pakchoi autotetraploids [PDF]

BMC Plant Biology
Background Breeding for polyploidy in Brassica campestris L. has been employed to enhance agronomic traits. Polyploid plants exhibit improved productivity due to the ‘gigas’ effect driven by chromosome doubling.
Weihua Tang, Jinshuang Zheng, Chengzhen Sun, Qi Pan   +3 more
doaj   +2 more sources

Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor [PDF]

Pharmaceuticals
P2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to the ...
Jonathas Albertino De Souza Oliveira Carneiro, Guilherme Pegas Teixeira, Leandro Rocha, Robson Xavier Faria   +3 more
doaj   +2 more sources

P2X Technology Progress and Simulation Studies on Its Participation in Power System Operation Optimization

Zhongguo dianli, 2021
As a cutting-edge technological concept, P2X represents the conversion of electrical energy to heat, cold, gas and other forms of energy. Based on the basic concept of P2X, this paper reviews the P2X technology system, evaluates the economics and ...
Ning ZHANG, Hongcai DAI, Yinan WANG, Lin LIU, Fang TANG, Nan XU   +5 more
doaj   +1 more source

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]

PLoS ONE, 2013
We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M Ojcius   +7 more
doaj   +1 more source

Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice. [PDF]

PLoS ONE, 2009
Recent evidence suggests that interleukin-1beta (IL-1beta), which was originally identified as a proinflammatory cytokine, is also required in the brain for memory processes.
Virginie F Labrousse, Laurence Costes, Agnès Aubert, Muriel Darnaudéry, Guillaume Ferreira, Thierry Amédée, Sophie Layé   +6 more
doaj   +1 more source

Direct observation of ATP-induced conformational changes in single P2X(4) receptors. [PDF]

PLoS Biology, 2009
The ATP-gated P2X(4) receptor is a cation channel, which is important in various pathophysiological events. The architecture of the P2X(4) receptor in the activated state and how to change its structure in response to ATP binding are not fully understood.
Youichi Shinozaki, Koji Sumitomo, Makoto Tsuda, Schuichi Koizumi, Kazuhide Inoue, Keiichi Torimitsu   +5 more
doaj   +1 more source

P2X receptors in neuroglia [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractDifferent types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in ...
Verkhratsky, A.; id_orcid 0000-0003-2592-9898, Pankratov, Y., Lalo, U., Nedergaard, M.   +3 more
openaire   +3 more sources

Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. [PDF]

PLoS ONE, 2011
Improper wound repair of the corneal epithelium can alter refraction of light resulting in impaired vision. We have shown that ATP is released after injury, activates purinergic receptor signaling pathways and plays a major role in wound closure. In many
Courtney Mankus, Celeste Rich, Martin Minns, Vickery Trinkaus-Randall   +3 more
doaj   +1 more source

Systematic effects of flexible power-to-X operation in a renewable energy system - A case study from Japan

Energy Conversion and Management: X, 2023
For achieving a carbon–neutral energy system, economical flexibility mechanisms are crucial to accommodate intermittent and decentralized renewable energy sources. Power-to-X (P2X) is a promising technology for this purpose.
Hiroaki Onodera, Rémi Delage, Toshihiko Nakata   +2 more
doaj   +1 more source