Results 21 to 30 of about 16,178 (230)

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

Molecular Neurodegeneration, 2011
Background Previous studies indicate a role of P2X7 receptors in processes that lead to neuronal death. The main objective of our study was to examine whether genetic deletion or pharmacological blockade of P2X7 receptors influenced dopaminergic cell ...
Kittel Ágnes, Madarász Emilia, Gölöncsér Flóra, Csölle Cecilia, Baranyi Mária, Hracskó Zsuzsanna, Sperlágh Beáta   +6 more
doaj   +1 more source

A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family. [PDF]

PLoS ONE, 2012
Phosphoinositides modulate the function of several ion channels, including most ATP-gated P2X receptor channels in neurons and glia, but little is known about the underlying molecular mechanism.
Louis-Philippe Bernier, Dominique Blais, Éric Boué-Grabot, Philippe Séguéla   +3 more
doaj   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
B. F. King, H. Kim, Ji, Xiao-Duo, Camaioni, Emidio, King, Brian F., A. Rychkov, A. Bartolini, Boyer, Jos L., Waktolla, GF, Mohanram, Arvind, F. Giuliani, K. A. Jacobson, Jacobson, Kenneth A., Y. C. Kim, Burnstock, Geoffrey, Park, HS, J. L. Boyer, Ziganshin, Airat U., S. S. Wildman, Harden, T. Kendall, Yoburn, Joshua, N. Galeotti, Galeotti, Nicoletta, Kass, GEN, A. U. Ziganshin, J.o. Yoburn, Sarkardei, S, C. Ghelardini, Tennant, JP, Wildman, Scott S.P., Rychkov, Alexei, T. K. Harden, G. Burnstock, Kim, Heaok, D. Barlocco, Bartolini, Alessandro, Kim, Yong-Chul, Boyer, José L., Ghelardini, Carla, Wildman, Scott S., Hourani, SMO, A. Mohanram, X. D. Ji   +42 more
core   +1 more source

Activation of P2X₇-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice

BMC Cancer, 2009
Background The study tested the hypothesis that apoptosis can prevent and control growth of neoplastic cells. Previous studies in-vitro have shown that the pro-apoptotic P2X7 receptor regulates growth of epithelial cells.
Fu Wen, McCormick Tom, Qi Xiaoping, Luo Liping, Zhou Lingyin, Li Xin, Wang Bing-Cheng, Gibbons Heidi E, Abdul-Karim Fadi W, Gorodeski George I   +9 more
doaj   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Lalo, Ulyana, Pankratov, Yuriy, Verkhratsky, A. N. (Alekseĭ Nestorovich), Wichert, S., Kirchhoff, F., Rossner, Moritz J., Verkhratsky, Alexei; id_orcid, Kirchhoff, Frank, Verkhratsky, Alexei, Pankratov, Y., Rossner, M., Lalo, U., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), North, R., Pankratov, Yuri, North, R. Alan, Verkhratsky, A., Wichert, Sven P.   +17 more
core   +1 more source

Research progress in the role of P2X receptors in oral maxillofacial pain

口腔疾病防治, 2018
Oral maxillofacial pain is one of the most common symptoms that greatly influences patients′ quality of life. Infectious diseases, nerve injuries and tumors in the oromaxillofacial region can cause facial pain.
HE Lingkun, XIONG Wei
doaj   +1 more source

Unveiling the Structure-Activity Relationships at the Orthosteric Binding Site of P2X Ion Channels: The Route to Selectivity.

, 2022
The orthosteric ATP-binding site of the P2X receptors is poorly understood. Only a few compounds were well characterized for their P2X receptor functional activity and subtype selectivity. This study represents the first fully functional characterization
Friederike Theresa, Füsser, Oliver , Koch, Anna, Junker, Clemens, Dobelmann, Katharina Sophie, Erlitz, Andreas, Isaak   +5 more
core   +1 more source

Introduction and perspective, historical note

Frontiers in Cellular Neuroscience, 2013
P2 nucleotide receptors were proposed to consist of two subfamilies based on pharmacology in 1985, named P2X and P2Y receptors. Later, this was confirmed following cloning of the receptors for nucleotides and studies of transduction mechanisms in the ...
Geoffrey eBurnstock
doaj   +1 more source

To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

Frontiers in Pharmacology, 2020
The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and ...
Leanne Stokes, Stefan Bidula, Lučka Bibič, Elizabeth Allum   +3 more
doaj   +1 more source