Results 41 to 50 of about 16,178 (230)
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
A shared mechanism for TNP-ATP recognition by members of the P2X receptor family
Computational and Structural Biotechnology JournalP2X receptors (P2X1–7) are non-selective cation channels involved in many physiological activities such as synaptic transmission, immunological modulation, and cardiovascular function.
Xiao-Bo Ma +11 more
doaj +1 more source
The Necessity of Dynamic Workflow Managers for Advancing Self‐Driving Labs and Optimizers
Advanced Intelligent Discovery, EarlyView.We assess the maturity and integration readiness of key methodologies for Materials Acceleration Platforms, highlighting the need for dynamic workflow managers. Demonstrating this, we integrate PerQueue into a color‐mixing robot, showing how flexible orchestration improves coordination and optimization.
Simon K. Steensen +6 more
wiley +1 more source
Resveratrol-decreased hyperalgesia mediated by the P2X receptor in gp120-treated rats
Molecular Pain, 2017 Background Chronic pain is a common symptom in human immunodeficiency virus (HIV)-1 infection/acquired immunodeficiency syndrome patients. The literature shows that the HIV envelope glycoprotein 120 (gp120) can directly cause hyperalgesia by stimulating ...
Bing Wu +13 more
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.A machine learning‐guided self‐driving laboratory screened over 500 nickel‐based layered double‐hydroxide catalysts for alkaline oxygen evolution. Out of the eight metals, the robot uncovered a quaternary Ni–Fe–Cr–Co catalysts requiring only 231 mV overpotential to reach 20 mA cm−2.
Nis Fisker‐Bødker +3 more
wiley +1 more source
Heteromeric assembly of P2X subunits [PDF]
Frontiers in Cellular Neuroscience, 2013 Published by Frontiers Research Foundation ...
Anika eSaul +4 more
openaire +4 more sources
Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases
Frontiers in Physiology, 2021 P2X receptors (P2XRs) are trimeric, non-selective cation channels activated by extracellular ATP and widely distributed in the digestive system. P2XRs have an important role in the physiological function of the digestive system, such as neurotransmission,
Qimin An +23 more
doaj +1 more source
The Interoperability Challenge in DFT Workflows Across Implementations
Advanced Intelligent Discovery, EarlyView.Interoperability and cross‐validation remain major challenges in the computational materials science. In this work, we introduce a common input/output standard that enables internal translation across multiple workflow managers—AiiDA, PerQueue, Pipeline Pilot, and SimStack—while producing results in a unified schema.
Simon K. Steensen +13 more
wiley +1 more source
Point Mutation in the Mouse P2X Receptor Affects Intercellular Calcium Waves in Astrocytes
ASN Neuro, 2009 Purinergic P2 receptors and gap junctions are two groups of proteins involved in the transmission of ICWs (intercellular calcium waves) between astrocytes.
Sylvia O Suadicani +3 more
doaj +1 more source
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source