Results 1 to 10 of about 28,114 (251)

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction [PDF]

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +4 more sources

ATP drives eosinophil effector responses through P2 purinergic receptors

Allergology International, 2015
Background: Eosinophils recognize various stimuli, such as cytokines, chemokines, immunoglobulins, complement, and external pathogens, resulting in their accumulation in mucosal tissues and the progression of inflammation.
Takehito Kobayashi, Tomoyuki Soma, Toru Noguchi, Kazuyuki Nakagome, Hidetomo Nakamoto, Hirohito Kita, Makoto Nagata   +6 more
doaj   +4 more sources

Role of Nucleotide P2 Receptors in the Immune System: Focus on Effector T Cells [PDF]

Cells
The emergence of purinergic signaling has given ATP and other extracellular nucleotides a whole new perspective. This concept refers to the fact that extracellular nucleotides released by most cells act as signaling molecules via specific membrane ...
Romuald Brice Babou Kammoe, Chakib Hamoudi, Fawzi Aoudjit   +2 more
doaj   +2 more sources

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

Brain Research Bulletin, 2023
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj   +3 more sources

Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy

Journal of Inflammation Research, 2021
Tobias Engel,1,2,* Jonathon Smith,1,2,* Mariana Alves1 1Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland; 2FutureNeuro, Science Foundation ...
Engel T, Smith J, Alves M
doaj   +2 more sources

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival

Frontiers in Cellular Neuroscience, 2019
Purinergic signaling regulates important physiological processes and the homeostatic response to stress in the cochlea via extracellular nucleosides (adenosine) and nucleotides (ATP, UTP).
Shelly C. Y. Lin, Peter R. Thorne, Gary D. Housley, Srdjan M. Vlajkovic   +3 more
doaj   +2 more sources

Purinergic Regulation of Neutrophil Function

Frontiers in Immunology, 2018
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen, Chen Deyu
exaly   +3 more sources

Purinergic Receptors in Dendritic Cells [PDF]

Journal of Inflammation Research
Miaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY
doaj   +2 more sources

P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction

Frontiers in Pharmacology, 2020
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Lucas T. Woods, Lucas T. Woods, Kimberly J. Jasmer, Kimberly J. Jasmer, Kevin Muñoz Forti, Kevin Muñoz Forti, Jean M. Camden, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman, Gary A. Weisman   +15 more
doaj   +2 more sources

Purine and purinergic receptors

Brain and Neuroscience Advances, 2018
Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a
Geoffrey Burnstock
doaj   +2 more sources