Results 41 to 50 of about 28,114 (251)
Role of P2-purinergic receptors in rat Leydig cell steroidogenesis [PDF]
Biochemical Journal, 1996 The present study investigated the effects of extracellular ATP on the intracellular calcium ion concentration ([Ca2+]i) and testosterone production in isolated adult rat Leydig cells. This nucleotide caused an increase in [Ca2+]i, with a maximal effect at a concentration of 100 µM ATP, comprising a rapid initial spike followed by a long-lasting ...
FORESTA, CARLO +5 more
openaire +4 more sources
Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]
, 2005 Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn +9 more
core +1 more source
Journal of Neuroscience, 2006 The cellular mechanism(s) by which the brain senses changes in pH to regulate breathing (i.e., central chemoreception) have remained incompletely understood, in large part because the central respiratory chemoreceptors have themselves eluded detection ...
D. Mulkey +3 more
semanticscholar +1 more source
Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]
, 2014 Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana +17 more
core +1 more source
Journal of Cellular and Molecular Medicine, 2012 Blood levels of extracellular nucleotides (e.g. ATP) are greatly increased during heart ischaemia, but, despite the presence of their specific receptors on cardiomyocytes (both P2X and P2Y subtypes), their effects on the subsequent myocardial damage are ...
Simona Cosentino +5 more
semanticscholar +1 more source
P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells
Biomolecules, 2022 Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected
Valentina Vultaggio-Poma, F. Di Virgilio
semanticscholar +1 more source
P2X and P2Y receptor signaling in red blood cells
Frontiers in Molecular Biosciences, 2015 Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter +2 more
doaj +1 more source
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +1 more source
Ocular P2 receptors and glaucoma.
Neuropharmacology, 2022 Adenosine triphosphate (ATP), an energy source currency in cells, is released or leaked to the extracellular space under both physiological and pathological conditions. Extracellular ATP functions as an intercellular signaling molecule through activation
Youichi Shinozaki +3 more
semanticscholar +1 more source
Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia
Journal of Neuroinflammation, 2009 Microglia are implicated in multiple neurodegenerative disorders, many of which display sexual dimorphisms and have symptom onsets at different ages. P2 purinergic receptors are critical for regulating various microglial functions, but little is known ...
Nikodemova Maria +2 more
doaj +1 more source