Neonatal Seizures and Purinergic Signalling [PDF]
International Journal of Molecular Sciences, 2020 Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains ...
Aida Menéndez-Méndez +2 more
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From purines to purinergic signalling: molecular functions and human diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Purines and their derivatives, most notably adenosine and ATP, are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.
Shuguang Yu, Henning Ulrich, Yong Tang
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Purinergic Signalling: Therapeutic Developments [PDF]
Frontiers in Pharmacology, 2017 Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj +6 more sources
Purinergic Signalling in Group A Streptococcus Pathogenesis [PDF]
Frontiers in Immunology, 2022 Streptococcus pyogenes (Group A Streptococcus; GAS) is a human specific bacterial pathogen, recognised globally as one of the top ten leading causes of infectious disease mortality.
T. B-D McEwan +5 more
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Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts [PDF]
Frontiers in Endocrinology, 2023 Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che +9 more
doaj +2 more sources
Purinergic Signalling and Inflammation-Related Diseases [PDF]
Cells, 2022 While acute inflammation is widely accepted as an important response mechanism of cells against tissue injury, sustained inflammatory processes are increasingly recognized as one of the main contributors to numerous diseases, including central-nervous ...
Tobias Engel +2 more
doaj +2 more sources
Editorial: Purinergic signalling in the central nervous system and its pharmacological importance in neurological and psychiatric illnesses [PDF]
Frontiers in Pharmacology, 2023 Yong Tang +5 more
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A Systematic Review of the Role of Purinergic Signalling Pathway in the Treatment of COVID-19 [PDF]
International Journal of Molecular Sciences, 2023 Liziane R Beckenkamp +2 more
exaly +2 more sources
Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management [PDF]
Arrhythmia & Electrophysiology Review, 2020 Gareth DK Matthews, Andrew A Grace
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Frontiers in Neuroscience, 2021 One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the ...
Adnan Hassan Tahir +5 more
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