Results 21 to 30 of about 246,268 (219)
Association of the ADORA2A receptor and CD73 polymorphisms with epilepsy
Frontiers in Pharmacology, 2023 Single-nucleotide polymorphisms are connected with the risk of epilepsy on occurrence, progress, and the individual response to drugs. Progress in genomic technology is exposing the complex genetic architecture of epilepsy.
Nan-Rui Shi +16 more
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Frontiers in Pharmacology, 2021 Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world.
Jie Li +8 more
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Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
Frontiers in Pharmacology, 2021 The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso +8 more
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Astrocytes in human central nervous system diseases: a frontier for new therapies
Signal Transduction and Targeted Therapy, 2023 Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can ...
Alexei Verkhratsky +7 more
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Purinergic signaling in epilepsy [PDF]
Journal of Neuroscience Research, 2016 Until recently, analysis of the mechanisms underlying epilepsy was centered on neuron dysfunctions. Accordingly, most of the available pharmacological treatments aim at reducing neuronal excitation or at potentiating neuronal inhibition. These therapeutic options can lead to obvious secondary effects, and, moreover, seizures cannot be controlled by any
Rassendren, François, Audinat, Etienne
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Purinergic Signaling in Spermatogenesis
Frontiers in Endocrinology, 2022 Adenosine triphosphate (ATP) serves as the essential source of cellular energy. Over the last two decades, however, ATP has also attracted increasing interest as an extracellular signal that activates purinergic plasma membrane receptors of the P2 family.
Nadine Mundt +5 more
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Purinergic signaling in the ovary [PDF]
Molecular Reproduction and Development, 2015 SUMMARYAdenosine triphosphate (ATP) is released from the cell by multiple mechanisms. The extracellular form of this purine is processed by ectonucleotidases, resulting in a variety of dephosphorylated metabolites that can bind to specific receptors found in the membrane of target cells; such purinergic signaling is important as an autocrine‐paracrine ...
Angélica S, Martínez-Ramírez +1 more
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Electroacupuncture prevents astrocyte atrophy to alleviate depression
Cell Death and Disease, 2023 Astrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD) in humans and in animal models of depression. Here we show that electroacupuncture prevents astrocyte atrophy in the prefrontal cortex and alleviates depressive ...
Si-Si Lin +8 more
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Purinergic signalling and cancer [PDF]
Purinergic Signalling, 2013 Receptors for extracellular nucleotides are widely expressed by mammalian cells. They mediate a large array of responses ranging from growth stimulation to apoptosis, from chemotaxis to cell differentiation and from nociception to cytokine release, as well as neurotransmission.
Burnstock G, DI VIRGILIO, Francesco
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, 2022 Since the discovery of ATP as an extracellular signalling molecule in 1972, purinergic signalling, mediated by extracellular purines and pyrimidines has been identified in virtually all mammalian tissues and is implicated in regulating fundamental ...
Vlajkovic, Srdjan M. +5 more
core +1 more source