Results 41 to 50 of about 7,573 (248)

Evolutionary origins of taste buds: phylogenetic analysis of purinergic neurotransmission in epithelial chemosensors [PDF]

Open Biology, 2013
Taste buds are gustatory endorgans which use an uncommon purinergic signalling system to transmit information to afferent gustatory nerve fibres. In mammals, ATP is a crucial neurotransmitter released by the taste cells to activate the afferent nerve ...
Masato Kirino, Jason Parnes, Anne Hansen, Sadao Kiyohara, Thomas E. Finger   +4 more
doaj   +1 more source

Glial Purinergic Signaling in Neurodegeneration [PDF]

Frontiers in Neurology, 2021
Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-specific expression patterns of purinergic signaling components change in neurodegeneration and how
Marie J. Pietrowski, Amr Ahmed Gabr, Amr Ahmed Gabr, Stanislav Kozlov, David Blum, David Blum, Annett Halle, Annett Halle, Kevin Carvalho, Kevin Carvalho   +9 more
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Purinergic Signaling in Bone [PDF]

Journal of Osteoporosis, 2013
In recent years, it has become apparent that extracellular nucleotides, signalling via P2 receptors, play an important role in the regulation of bone turnover. Furthermore, purinergic signalling has been associated in the pathophysiology of several bone and cartilage diseases, including osteoarthritis, rheumatoid arthritis, and osteoporosis and might ...
Niklas Rye Jørgensen, Elena Adinolfi, Isabel Orriss, Peter Schwarz   +3 more
openaire   +4 more sources

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad   +17 more
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Purinergic signaling in kidney disease [PDF]

Kidney International, 2017
Nucleotides are key subunits for nucleic acids and provide energy for intracellular metabolism. They can also be released from cells to act physiologically as extracellular messengers or pathologically as danger signals. Extracellular nucleotides stimulate membrane receptors in the P2 and P1 family. P2X are ATP-activated cation channels; P2Y and P1 are
Tam, FWK, Menzies, RI, Unwin, RJ, Bailey, MA   +3 more
openaire   +5 more sources

Delineating Purinergic Signaling in Drosophila

International Journal of Molecular Sciences, 2022
Simplistic models can aid in discovering what is important in the context of normal and pathological behavior. First recognized as a genetic model more than 100 years ago, to date, fruit flies (Drosophila melanogaster) still remain an astonishingly good laboratory stand-in for scientists to study development and physiology and to investigate the ...
Cinzia Volonte', Francesca Alberti, Giuseppe Vitale, Francesco Liguori   +3 more
openaire   +2 more sources

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders

Brain Sciences, 2023
Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec, Anna Wilkaniec, Marta Matuszewska, Ewelina Pałasz, Magdalena Cieślik, Agata Adamczyk   +5 more
doaj   +1 more source

Purinergic signaling in scarring

The FASEB Journal, 2015
ABSTRACT Adenosine (ADO) and nucleotides such as ATP, ADP, and uridine 5'‐triphosphate (UTP), among others, may serve as extracellular signaling molecules. These mediators activate specific cell‐surface receptors—namely, purinergic 1 and 2 (P1 and P2)—to modulate crucial pathophysiological responses. Regulation of
FERRARI, Davide, GAMBARI, Roberto, Idzko, Marco, Müller, Tobias, Albanesi, Cristina, Pastore, Saveria, La Manna, Gaetano, Robson, Simon C, Cronstein, Bruce   +8 more
openaire   +5 more sources

NPP1 is responsible for potent extracellular ATP hydrolysis as NTPDase1 in primary cultured murine microglia [PDF]

, 2018
The movement of microglia is regulated mainly by P1 and P2 purinergic receptors, which are activated by various nucleotides and their metabolites.
이민구, 김주영
core   +1 more source

A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer

Frontiers in Bioscience-Landmark, 2022
Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall, Dan C Gagui, Victoria L Tippett, Norain B Ab Latif, Karan M Shah, Alison Gartland   +5 more
doaj   +1 more source