Results 51 to 60 of about 246,268 (219)

Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain

Frontiers in Neurology
BackgroundSeveral studies have confirmed the direct relationship between extracellular acidification and the occurrence of pain. As an effective pain management approach, the mechanism of electroacupuncture (EA) treatment of acidification-induced pain is
Qing Ye, Jie Li, Wen-Jing Ren, Ying Zhang, Tao Wang, Patrizia Rubini, Hai-Yan Yin, Peter Illes, Peter Illes, Yong Tang, Yong Tang   +10 more
doaj   +1 more source

Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities

Pharmacological Research
Major depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy.
Xing-Ying Ren, Patrizia Rubini, Tobias Engel, Yong Tang, Peter Illes   +4 more
doaj   +1 more source

ATP and Adenosine in the Retina and Retinal Diseases

Frontiers in Pharmacology, 2021
Extracellular ATP and its ultimate degradation product adenosine are potent extracellular signaling molecules that elicit a variety of pathophysiological pathways in retina through the activation of P2 and P1 purinoceptors, respectively.
Shan-Shan Ye, Yong Tang, Yong Tang, Jian-Tao Song   +3 more
doaj   +1 more source

Dissecting the Purinergic Signaling Puzzle

International Journal of Molecular Sciences, 2021
Purinergic signaling regulates a plethora of physiological processes and is an expanding research field [...]
Raquel Pérez-Sen, Esmerilda G. Delicado
openaire   +4 more sources

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation

Respiratory Research, 2022
Background Chronic obstructive pulmonary disease (COPD) is associated with elevated ATP levels in the extracellular space. Once released, ATP serves as danger signal modulating immune responses by activating purinergic receptors.
Sven Schneider, Irmgard Merfort, Marco Idzko, Andreas Zech   +3 more
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

, 2011
Despite improvements in prevention and management of colorectal cancer (CRC), uncontrolled tumor growth with metastatic spread to distant organs remains an important clinical concern.
Enjyoji, Keiichi, Käser, Samuel, Dwyer, Karen, Bernlochner, Maria-Isabell, Csizmadia, Eva, Rath, Stephan, Friess, Helmut, d'Apice, Anthony, Robson, Simon C, Maurer, Christoph A, Künzli, Beat M, Cowan, Peter, Perren, Aurel, Rosenberg, Robert   +13 more
core   +1 more source

Purinergic Signaling in the Hallmarks of Cancer [PDF]

Cells, 2020
Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic strategies has been constant.
Anaí del Rocío Campos-Contreras, Mauricio Díaz-Muñoz, Francisco G. Vázquez-Cuevas   +2 more
openaire   +3 more sources

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source