Purinergic P2 Receptors: Novel Mediators of Mechanotransduction. [PDF]
Front Pharmacol, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Kong Q, Quan Y, Tian G, Zhou J, Liu X.
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Degranulation of human mast cells: modulation by P2 receptors' agonists. [PDF]
Front Immunol, 2023 Since the late 1970s, there has been an alarming increase in the incidence of asthma and its morbidity and mortality. Acute obstruction and inflammation of allergic asthmatic airways are frequently caused by inhalation of exogenous substances such as ...
Schulman ES, Nishi H, Pelleg A.
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Altered Purinergic Signaling in Neurodevelopmental Disorders: Focus on P2 Receptors. [PDF]
Biomolecules, 2023 With the umbrella term ‘neurodevelopmental disorders’ (NDDs) we refer to a plethora of congenital pathological conditions generally connected with cognitive, social behavior, and sensory/motor alterations.
Boccazzi M +4 more
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P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction. [PDF]
Front Pharmacol, 2020 Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Khalafalla MG +8 more
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Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy. [PDF]
J Inflamm Res, 2021 Tobias Engel,1,2,* Jonathon Smith,1,2,* Mariana Alves1 1Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland; 2FutureNeuro, Science Foundation ...
Engel T, Smith J, Alves M.
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P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells. [PDF]
Biomolecules, 2022 Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected
Vultaggio-Poma V, Di Virgilio F.
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Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function. [PDF]
Front Immunol, 2020 Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Ledderose C, Junger WG.
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Modeling Interactions among Individual P2 Receptors to Explain Complex Response Patterns over a Wide Range of ATP Concentrations. [PDF]
Front Physiol, 2016 EExtracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts.
Xing S +4 more
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Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]
PLoS One, 2016 ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Alberto AV +8 more
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Role of Nucleotide P2 Receptors in the Immune System: Focus on Effector T Cells. [PDF]
CellsThe emergence of purinergic signaling has given ATP and other extracellular nucleotides a whole new perspective. This concept refers to the fact that extracellular nucleotides released by most cells act as signaling molecules via specific membrane ...
Babou Kammoe RB, Hamoudi C, Aoudjit F.
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