Results 21 to 30 of about 130,183 (288)
Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. [PDF]
PLoS ONE, 2016 ATP and other nucleotides are released from cells through regulated pathways or following the loss of plasma membrane integrity. Once outside the cell, these compounds can activate P2 receptors: P2X ionotropic receptors and G protein-coupled P2Y ...
Anael Viana Pinto Alberto +8 more
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Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function [PDF]
Frontiers in Immunology, 2020 Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Carola Ledderose, Wolfgang G. Junger
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Role of Nucleotide P2 Receptors in the Immune System: Focus on Effector T Cells [PDF]
CellsThe emergence of purinergic signaling has given ATP and other extracellular nucleotides a whole new perspective. This concept refers to the fact that extracellular nucleotides released by most cells act as signaling molecules via specific membrane ...
Romuald Brice Babou Kammoe +2 more
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Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources [PDF]
Frontiers in Pharmacology, 2020 P2 receptors are a family of transmembrane receptors activated by nucleotides and nucleosides. Two classes have been described in mammals, P2X and P2Y, which are implicated in various diseases.
Anael Viana Pinto Alberto +3 more
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Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery [PDF]
Molecules, 2012 Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves +4 more
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Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice [PDF]
Scientific Reports, 2018 The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Chun Yang +8 more
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Purinergic Receptors in Dendritic Cells [PDF]
Journal of Inflammation ResearchMiaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY
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Purinergic P2 Receptors: Structure and Function 2.0. [PDF]
Int J Mol Sci, 2023 This Special Issue of the International Journal of Molecular Sciences (IJMS) is a direct continuation of the previous Special Issue of this journal, entitled “Purinergic P2 Receptors: Structure and Function” https://www [...]
Zemkova H.
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Physiologic roles of P2 receptors in leukocytes. [PDF]
J Leukoc Biol, 2022 AbstractSince their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides,
Alberto AVP +10 more
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P2 receptors in renal autoregulation. [PDF]
Curr Vasc Pharmacol, 2014 Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Guan Z +3 more
europepmc +4 more sources