Results 21 to 30 of about 730,869 (229)

Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies

Journal of Pharmacological Sciences, 2022
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling.
Kazuhide Inoue
doaj   +1 more source

P2-type purinergic signaling in the regulation of pancreatic β-cell functional plasticity as a promising novel therapeutic approach for the treatment of type 2 diabetes?

Frontiers in Endocrinology, 2022
Diabetes Mellitus is a metabolic disorder characterized by a chronic hyperglycemia due to an impaired insulin secretion and a decreased in peripheral insulin sensitivity. This disease is a major public health problem due to it sharp prevalence. Therefore,
Nour Mesto, Jamileh Movassat, Cécile Tourrel-Cuzin   +2 more
doaj   +1 more source

Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]

, 2007
Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core   +3 more sources

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

Brain Research Bulletin, 2023
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj   +1 more source

P2X and P2Y receptor signaling in red blood cells

Frontiers in Molecular Biosciences, 2015
Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter, Ronald eSluyter, Ronald eSluyter   +2 more
doaj   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M., Peppiatt-Wildman, C. M., Wildman, S. S., R. E. Birch, C. M. Peppiatt-Wildman, Scott S Wildman, Schwiebert, E. M., Wildman, Scott S.P., E. M. Schwiebert, S. S. Wildman, Birch, R. E.   +10 more
core   +1 more source

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells

BMC Immunology, 2004
Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders, Jacobsen Sten Eirik W, Wang Lingwei, Erlinge David   +3 more
doaj   +1 more source

Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

BMC Immunology, 2006
Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo, Kong In Deok, Park Kyu Sang, Lee Dong Hyeon, Han Bok Ghee   +4 more
doaj   +1 more source

Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. [PDF]

Cell Mol Life Sci, 2016
Ectodomain shedding of integral membrane receptors results in the release of soluble molecules and modification of the transmembrane portions to mediate or modulate extracellular and intracellular signalling.
Pupovac A, Sluyter R.
europepmc   +3 more sources

Purinergic Signaling in Liver Pathophysiology

Frontiers in Endocrinology, 2021
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj   +1 more source