Results 21 to 30 of about 60,226 (246)
Microbes Infect, 2012 Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release ...
Rayah A +2 more
europepmc +4 more sources
Molecules, 2022 Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato +9 more
doaj +1 more source
P2 Receptors in Health and Disease [PDF]
Biotechnology and Genetic Engineering Reviews, 2006 In the past ten years since the discovery and cloning of members of the P2 receptor family, rapid progress has been made in the field regarding the function and pharmacology of different P2 receptor subtypes. This research resulted in identifying these receptors as important players in the pathology of atherosclerosis, cystic fibrosis ...
Gary A, Weisman +5 more
openaire +2 more sources
Frontiers in Endocrinology, 2022 Diabetes Mellitus is a metabolic disorder characterized by a chronic hyperglycemia due to an impaired insulin secretion and a decreased in peripheral insulin sensitivity. This disease is a major public health problem due to it sharp prevalence. Therefore,
Nour Mesto +2 more
doaj +1 more source
P2 receptors and platelet function. [PDF]
Purinergic Signal, 2011 Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive feedback mechanism to cause further platelet activation and amplify ...
Hechler B, Gachet C.
europepmc +4 more sources
Brain Research Bulletin, 2023 Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj +1 more source
P2 receptors in renal pathophysiology [PDF]
Purinergic Signalling, 2009 Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor subtypes found in the kidney suggest that any disturbance of function may contribute to several pathological ...
Clare M, Turner +2 more
openaire +2 more sources
P2X and P2Y receptor signaling in red blood cells
Frontiers in Molecular Biosciences, 2015 Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter +2 more
doaj +1 more source
BMC Immunology, 2004 Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y receptors.
Bengtsson Anders +3 more
doaj +1 more source
BMC Immunology, 2006 Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo +4 more
doaj +1 more source