Results 11 to 20 of about 60,226 (246)
Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies
Journal of Pharmacological Sciences, 2022 Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling.
Kazuhide Inoue
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P2 Receptors and Platelet Activation [PDF]
The Scientific World Journal, 2002 Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors.
Satva P. Kunapuli
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Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources. [PDF]
Front Pharmacol, 2020 P2 receptors are a family of transmembrane receptors activated by nucleotides and nucleosides. Two classes have been described in mammals, P2X and P2Y, which are implicated in various diseases.
Alberto AVP +3 more
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Research articleHemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors. [PDF]
Virulence, 2018 Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Gao J +10 more
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Action of natural products on p2 receptors: a reinvented era for drug discovery. [PDF]
Molecules, 2012 Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Faria R +4 more
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Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice. [PDF]
Sci Rep, 2018 The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Yang C +8 more
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Physiologic roles of P2 receptors in leukocytes. [PDF]
J Leukoc Biol, 2022 AbstractSince their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the adaptive immune response. In particular, P2 receptors, which respond to extracellular nucleotides,
Alberto AVP +10 more
europepmc +3 more sources
P2 receptors in renal autoregulation. [PDF]
Curr Vasc Pharmacol, 2014 Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Guan Z +3 more
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Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?
Cells, 2021 Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi +5 more
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Frontiers in Bioscience-Landmark, 2022 Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall +5 more
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