Results 1 to 10 of about 198,952 (138)

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation [PDF]

Frontiers in Pharmacology, 2019
Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space.
Linyu Wei, Fatema Mousawi, Dongliang Li, Sébastien Roger, Jing Li, Xuebin Yang, Lin-Hua Jiang, Lin-Hua Jiang, Lin-Hua Jiang   +8 more
doaj   +2 more sources

Recombinant SARS-Cov-2 spike protein S1 subunit upregulates P2 × 7-NLRP3 leading to macrophage pyroptosis promoting acute lung injury [PDF]

Respiratory Research
Background Our previous study confirmed recombinant SARS-CoV-2 spike protein subunit S1 (S1SP) independently induces acute lung injury (ALI), but its mechanism remains unclear. This study thoroughly investigates the role of the purinergic receptor P2 × 7
Manlu Lu, Mingzhen Li, Huijie Zhou, Jiwei Zhu, Qianqian Jiao, Xiaojing Liu, Jinglin Wu, Guogang Xu, Changjun Lv, Yichu Fan, Bin Zhang, Lei Pan   +11 more
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Design and immunogenicity of a recombinant Saccharomyces boulardii secreting the P2-VP8 subunit rotavirus vaccine [PDF]

Scientific Reports
Rotavirus is the leading cause of infectious diarrhea in children, and vaccination has significantly reduced the mortality rate. However, the current vaccines have not shown optimal effectiveness in developing countries.
Ibrahim Farhani, Ahad Yamchi, Hadi Razavi Nikoo, Fatemeh T. Shamsabadi, Shahriyar Abdoli, R. Holland Cheng, Majid Shahbazi   +6 more
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Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

Brain Research Bulletin, 2023
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj   +1 more source

Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies

Journal of Pharmacological Sciences, 2022
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been extensively studied in pain signaling.
Kazuhide Inoue
doaj   +1 more source

Activation of P2×7 Receptor Promotes the Invasion and Migration of Colon Cancer Cells via the STAT3 Signaling

Frontiers in Cell and Developmental Biology, 2020
The pathological mechanism of colon cancer is very complicated. Therefore, exploring the molecular basis of the pathogenesis of colon cancer and finding a new therapeutic target has become an urgent problem to be solved in the treatment of colon cancer ...
Wen-jun Zhang, Ce-gui Hu, Hong-liang Luo, Zheng-ming Zhu   +3 more
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Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts

Frontiers in Endocrinology, 2023
Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che, Hangxiu Che, Yaqun Wang, Jinhui Lao, Yixin Deng, Chirui Xu, Hanxiao Yin, Zheng Tang, Yonghong Huang, Hong Xu   +9 more
doaj   +1 more source

Mite allergen Der-p2 triggers human B lymphocyte activation and Toll-like receptor-4 induction. [PDF]

PLoS ONE, 2011
BACKGROUND: Allergic disease can be characterized as manifestations of an exaggerated inflammatory response to environmental allergens triggers. Mite allergen Der-p2 is one of the major allergens of the house dust mite, which contributes to TLR4 ...
Jaw Ji Tsai, Shing Hwa Liu, Sui Chu Yin, Cheng Ning Yang, Hong Sheng Hsu, Wen Bao Chen, En Chih Liao, Wen Jane Lee, Hung Chuan Pan, Meei Ling Sheu   +9 more
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A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer

Frontiers in Bioscience-Landmark, 2022
Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall, Dan C Gagui, Victoria L Tippett, Norain B Ab Latif, Karan M Shah, Alison Gartland   +5 more
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