Results 41 to 50 of about 199,121 (304)
P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]
, 2008 When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King +29 more
core +1 more source
Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties
Cell & Bioscience, 2023 Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging.
Ziyan Hu +8 more
doaj +1 more source
Membrane-mediated dimerization potentiates PIP5K lipid kinase activity
eLife, 2022 The phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family of lipid-modifying enzymes generate the majority of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] lipids found at the plasma membrane in eukaryotic cells.
Scott D Hansen +3 more
doaj +1 more source
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source
P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells
Biomolecules, 2022 Extracellular ATP (eATP) and P2 receptors are novel emerging regulators of T-lymphocyte responses. Cellular ATP is released via multiple pathways and accumulates at sites of tissue damage and inflammation. P2 receptor expression and function are affected
Valentina Vultaggio-Poma +1 more
doaj +1 more source
Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]
, 2002 Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R. +4 more
core +1 more source
Frontiers in Physiology, 2016 EExtracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts.
Shu Xing +4 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Virulence, 2018 Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao +10 more
doaj +1 more source
Whole Genome Sequence Analysis of Lactiplantibacillus plantarum Bacteriophage P2
Polish Journal of Microbiology, 2022 Phage P2 was isolated from failed fermentation broth carried out by Lactiplantibacillus plantarum IMAU10120. A previous study in our laboratory showed that this phage belonged to the Siphoviridae family.
Zhu Hanfang +6 more
doaj +1 more source