Results 11 to 20 of about 92,291 (308)

P2 receptor web: complexity and fine-tuning

Pharmacology & Therapeutics, 2006
The present review offers a new perspective on a family of receptors, termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize here that while decoding the inputs of various related extracellular ligands, P2
Burnstock, Geoffrey, Amadio, Susanna, Colpi, Monica, D'Ambrosi, Nadia, Volonté, Cinzia   +4 more
core   +5 more sources

Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts

Frontiers in Endocrinology, 2023
Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che, Hangxiu Che, Yaqun Wang, Jinhui Lao, Yixin Deng, Chirui Xu, Hanxiao Yin, Zheng Tang, Yonghong Huang, Hong Xu   +9 more
doaj   +1 more source

P2 Receptors in Health and Disease [PDF]

Biotechnology and Genetic Engineering Reviews, 2006
In the past ten years since the discovery and cloning of members of the P2 receptor family, rapid progress has been made in the field regarding the function and pharmacology of different P2 receptor subtypes. This research resulted in identifying these receptors as important players in the pathology of atherosclerosis, cystic fibrosis ...
Gary A, Weisman, Ningpu, Yu, Zhongji, Liao, Fernando, Gonzaléz, Laurie, Erb, Cheikh I, Seye   +5 more
openaire   +2 more sources

A Systematic Review of the Expression, Signalling and Function of P2 Receptors in Primary Bone Cancer

Frontiers in Bioscience-Landmark, 2022
Primary bone cancers are rare malignant diseases with significant morbidity and mortality. The treatment regimen relies on a combination of surgery (often involving amputation), chemotherapy and radiotherapy with outcomes dependent on localization of the
Luke Tattersall, Dan C Gagui, Victoria L Tippett, Norain B Ab Latif, Karan M Shah, Alison Gartland   +5 more
doaj   +1 more source

ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation. [PDF]

PLoS ONE, 2013
BACKGROUND: Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently implicated in lung inflammation. Extracellular nucleotides, such as ATP have been shown to act via activation of P2 purinoceptors, leading ...
Shin-Ei Cheng, I-Ta Lee, Chih-Chung Lin, Wan-Ling Wu, Li-Der Hsiao, Chuen-Mao Yang   +5 more
doaj   +1 more source

Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be investigated. Materials and Methods:
Shiba Yousefvand, Mousa-al-Reza Hadjzadeh, Zakieh Keshavarzi, Hamid Dolatshad, Farzaneh Vafaei, Maryam Mahmoudabady, Zahra Gholamzadeh Virany   +6 more
doaj   +1 more source

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
B. F. King, H. Kim, Ji, Xiao-Duo, Camaioni, Emidio, King, Brian F., A. Rychkov, A. Bartolini, Boyer, Jos L., Waktolla, GF, Mohanram, Arvind, F. Giuliani, K. A. Jacobson, Jacobson, Kenneth A., Y. C. Kim, Burnstock, Geoffrey, Park, HS, J. L. Boyer, Ziganshin, Airat U., S. S. Wildman, Harden, T. Kendall, Yoburn, Joshua, N. Galeotti, Galeotti, Nicoletta, Kass, GEN, A. U. Ziganshin, J.o. Yoburn, Sarkardei, S, C. Ghelardini, Tennant, JP, Wildman, Scott S.P., Rychkov, Alexei, T. K. Harden, G. Burnstock, Kim, Heaok, D. Barlocco, Bartolini, Alessandro, Kim, Yong-Chul, Boyer, José L., Ghelardini, Carla, Wildman, Scott S., Hourani, SMO, A. Mohanram, X. D. Ji   +42 more
core   +1 more source

P2 receptors in renal pathophysiology [PDF]

Purinergic Signalling, 2009
Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor subtypes found in the kidney suggest that any disturbance of function may contribute to several pathological ...
Clare M, Turner, James I, Elliott, Frederick W K, Tam   +2 more
openaire   +2 more sources

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Gurney Alison M, Gurney, Alison M.; id_orcid, Alison M Gurney, Kennedy, Charles, Krongkarn Chootip, Charles Kennedy, Gurney, Alison M., Chootip Krongkarn, Kennedy Charles   +9 more
core   +1 more source

P2 Receptors in Renal Autoregulation [PDF]

Current Vascular Pharmacology, 2014
Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Zhengrong, Guan, Robert C, Fellner, Justin, Van Beusecum, Edward W, Inscho   +3 more
openaire   +2 more sources