Results 11 to 20 of about 199,121 (304)

P2 receptors and platelet function [PDF]

Purinergic Signalling, 2011
Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive feedback mechanism to cause further platelet activation and amplify ...
Béatrice, Hechler, Christian, Gachet
openaire   +2 more sources

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +6 more sources

P2 Receptors in Renal Autoregulation [PDF]

Current Vascular Pharmacology, 2014
Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood.
Zhengrong, Guan, Robert C, Fellner, Justin, Van Beusecum, Edward W, Inscho   +3 more
openaire   +2 more sources

ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation. [PDF]

PLoS ONE, 2013
BACKGROUND: Up-regulation of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently implicated in lung inflammation. Extracellular nucleotides, such as ATP have been shown to act via activation of P2 purinoceptors, leading ...
Shin-Ei Cheng, I-Ta Lee, Chih-Chung Lin, Wan-Ling Wu, Li-Der Hsiao, Chuen-Mao Yang   +5 more
doaj   +1 more source

Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be investigated. Materials and Methods:
Shiba Yousefvand, Mousa-al-Reza Hadjzadeh, Zakieh Keshavarzi, Hamid Dolatshad, Farzaneh Vafaei, Maryam Mahmoudabady, Zahra Gholamzadeh Virany   +6 more
doaj   +1 more source

Structural insights on TRPV5 gating by endogenous modulators. [PDF]

, 2018
TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5.
Carnevale, Vincenzo, Carnevale|, Fluck, Edwin C., Hughes, Taylor E. T., Huynh, Kevin W., Kasimova, Marina A., Kasimova|, Moiseenkova-Bell, Vera Y., Molugu, Sudheer K., Pumroy, Ruth A., Rohacs, Tibor, Samanta, Amrita, Yazici, Aysenur Torun, Zhou, Z. Hong   +13 more
core   +3 more sources

P2 receptors in renal pathophysiology [PDF]

Purinergic Signalling, 2009
Our knowledge and understanding of the P2 receptor signalling system in the kidney have increased significantly in the last ten years. The broad range of physiological roles proposed for this receptor system and the variety of P2 receptor subtypes found in the kidney suggest that any disturbance of function may contribute to several pathological ...
Clare M, Turner, James I, Elliott, Frederick W K, Tam   +2 more
openaire   +2 more sources

ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source

Development of P2 olfactory glomeruli in P2-internal ribosome entry site-tau-lacZ transgenic mice [PDF]

, 1999
Primary olfactory neurons project their axons to the olfactory bulb, where they terminate in discrete loci called glomeruli. All neurons expressing the same odorant receptor appear to terminate in a few glomeruli in each olfactory bulb.
Key, Brian, Royal, Stephanie J.
core   +2 more sources

P2 receptors and immunity

Microbes and Infection, 2012
Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release ...
Rayah A, Kanellopoulos JM, DI VIRGILIO, Francesco   +2 more
openaire   +3 more sources