Results 31 to 40 of about 5,354,149 (260)

Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity

Frontiers in Neuroscience, 2021
One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the ...
Adnan Hassan Tahir, Adnan Hassan Tahir, Jia-Jia Li, Jia-Jia Li, Yong Tang, Yong Tang   +5 more
doaj   +1 more source

Short- and long-term (trophic) purinergic signalling. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2016
Burnstock G.
europepmc   +2 more sources

Association of the ADORA2A receptor and CD73 polymorphisms with epilepsy

Frontiers in Pharmacology, 2023
Single-nucleotide polymorphisms are connected with the risk of epilepsy on occurrence, progress, and the individual response to drugs. Progress in genomic technology is exposing the complex genetic architecture of epilepsy.
Nan-Rui Shi, Qi Wang, Jie Liu, Ji-Zhou Zhang, Bin-Lu Deng, Xiu-Min Hu, Jie Yang, Xin Wang, Xiang Chen, Yan-Qin Zuo, Ting-Ting Liu, Jia-Ling Zheng, Xin Yang, Peter Illes, Peter Illes, Yong Tang, Yong Tang   +16 more
doaj   +1 more source

Purinergic signalling in host innate immune defence against intracellular pathogens.

Biochemical Pharmacology, 2021
Purinergic signalling is an evolutionarily conserved signalling pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides released from host cells during intracellular pathogen infections activate plasma membrane ...
R. Coutinho-Silva, Luiz Eduardo Baggio Savio   +1 more
semanticscholar   +1 more source

Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule

Frontiers in Pharmacology, 2021
Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world.
Jie Li, Ying Zhang, Peter Illes, Peter Illes, Peter Illes, Yong Tang, Yong Tang, Patrizia Rubini, Patrizia Rubini   +8 more
doaj   +1 more source

Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake

Frontiers in Pharmacology, 2021
The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso, Vanni Caruso, Mariachiara Zuccarini, Mariachiara Zuccarini, Patrizia Di Iorio, Patrizia Di Iorio, Ishaq Muhammad, Maurizio Ronci, Maurizio Ronci   +8 more
doaj   +1 more source

Astrocytes in human central nervous system diseases: a frontier for new therapies

Signal Transduction and Targeted Therapy, 2023
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can ...
Alexei Verkhratsky, Arthur Butt, Baoman Li, Peter Illes, Robert Zorec, Alexey Semyanov, Yong Tang, Michael V. Sofroniew   +7 more
doaj   +1 more source

Correcting an overactive exercise pressor reflex: A new role for purinergic signalling? [PDF]

Experimental Physiology
Fiona D. McBryde
doaj   +2 more sources

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +9 more sources

Purinergic Signaling during Inflammation [PDF]

New England Journal of Medicine, 2012
Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.
Holger K, Eltzschig, Michail V, Sitkovsky, Simon C, Robson   +2 more
openaire   +4 more sources