Results 61 to 70 of about 677,196 (106)
Possible neuroprotective role of P2X2 in the retina of diabetic rats
Diabetology & Metabolic Syndrome, 2018 Background Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, there is
Jorge E. Mancini +6 more
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Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus
, 2021 ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and pathophysiological ...
Katharina Harr +4 more
core +1 more source
Purine and purinergic receptors
Brain and Neuroscience Advances, 2018 Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a
Geoffrey Burnstock
doaj +1 more source
Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves
Frontiers in Cellular Neuroscience, 2017 The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton +10 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 for nucleotides, they are ...
Fabio eCavaliere +2 more
doaj +1 more source
Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta
European Journal of Histochemistry, 2009 Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/ CD39) is the dominant ecto-nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type-2 purinergic (P2) Gprotein coupled receptors (GPCRs).
A Kittel +4 more
doaj +1 more source
PET imaging of purinergic receptors
, 2020 Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes
Windhorst, Albert D. +2 more
core +1 more source
Purines as potential morphogens during embryonic development [PDF]
, 2012 Components of purinergic signalling are expressed in the early embryo raising the possibility that ATP, ADP and adenosine may contribute to the mechanisms of embryonic development.
Dale, Nicholas +3 more
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Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice
Scientific Reports, 2018 The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Chun Yang +8 more
doaj +1 more source
An emerging role for adenosine and its receptors in bone homeostasis
Frontiers in Endocrinology, 2012 Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans +3 more
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