Results 61 to 70 of about 8,231 (179)

Purine and purinergic receptors

Brain and Neuroscience Advances, 2018
Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a
Geoffrey Burnstock
doaj   +1 more source

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton, Carlos Luna Lopez, Elisabeth Blevins, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I. Shestopalov, Helen P. Makarenkova, Sameer B. Shah, Sameer B. Shah, Sameer B. Shah   +10 more
doaj   +1 more source

Amino acid modulation of the carotid body selectively modulates peripheral chemoreceptor respiratory reflex

The Journal of Physiology, Volume 604, Issue 14, Page 6196-6224, 15 July 2026.
Abstract figure legend When the carotid body (CB) detects low oxygen levels (hypoxia), this leads to: (1) depolarization of the chemosensory cells (glomus cells) within the CB – the resulting increase in intracellular Ca2+ stimulates the exocytotic co‐release of vesicles containing ATP and glutamate; (2) synaptic ATP acts on postsynaptic petrosal ...
Olivia M. S. Gold, Audrys G. Pauza, Igor S. A. Felippe, Xin Shen, Julian F. R. Paton   +4 more
wiley   +1 more source

The functional role of P2 purinergic receptors in the progression of gastric cancer

Purinergic Signalling
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cells and GC tissues and correlates with their function. Endogenous nucleotides including ATP, ADP, UTP, and UDP, as P2 purinergic receptors activators, participate in P2 purinergic signal transduction pathway.
Zou, Fei-long, Liu, Ji-peng, Zuo, Cheng, He, Peng-fei, Ye, Jin-xiong, Zhang, Wen-jun   +5 more
openaire   +2 more sources

Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation

Frontiers in Cellular Neuroscience, 2015
Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 for nucleotides, they are ...
Fabio eCavaliere, Claudia eDonno, Nadia eD'Ambrosi   +2 more
doaj   +1 more source

P2 purinergic receptors on osteoblasts and osteoclasts: Potential targets for drug development

Drug Development Research, 2000
Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization and influx of Ca2+, whereas the P2Y receptor subtypes couple through G proteins to activation of phospholipase Cβ and mobilization of intracellular Ca2+. In nonskeletal
Dixon, S. Jeffrey, Sims, Stephen M.
openaire   +2 more sources

Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta

European Journal of Histochemistry, 2009
Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/ CD39) is the dominant ecto-nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type-2 purinergic (P2) Gprotein coupled receptors (GPCRs).
A Kittel, Zs Csapó, E Csizmadia, SW Jackson, SC Robson   +4 more
doaj   +1 more source

Modulation of Phagocytosis by P2-Purinergic Receptors in Mouse Peritoneal Macrophages.

The Japanese Journal of Physiology, 1995
The effects of adenosine 5'-triphosphate (ATP) and other nucleotides on phagocytosis of peritoneal macrophages were examined by means of flow cytometry (FCM). ATP and uridine 5'-triphosphate (UTP) enhanced phagocytosis in a dose-dependent manner. Control phagocytosis was partially suppressed in Ca(2+)-free solution.
openaire   +3 more sources

Extracellular ATP and Cancer—An Overview with Special Reference to P2 Purinergic Receptors

Pathology & Oncology Research, 2008
Purinergic signal transduction mechanisms have been appreciated as a complex intercellular signalling network that plays an important regulatory role in both short- and long-term processes in practically every living cell. One of the most intriguing aspects of the field is the participation of ATP and other purine nucleotides in the determination of ...
Tamás, Deli, László, Csernoch
openaire   +2 more sources

An emerging role for adenosine and its receptors in bone homeostasis

Frontiers in Endocrinology, 2012
Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans, Bronwen eEvans, Jack eHam, Jack eHam   +3 more
doaj   +1 more source