Results 61 to 70 of about 28,114 (251)

Purinergic signalling pathway: therapeutic target in ovarian cancer

Egyptian Journal of Medical Human Genetics, 2020
Background The lack of early diagnostic tools and the development of chemoresistance have made ovarian cancer (OC) one of the deadliest gynaecological cancers.
Nisha Chandran, Mahalaxmi Iyer, Zothan Siama, Balachandar Vellingiri, Arul Narayanasamy   +4 more
doaj   +1 more source

Purinergic signaling in the gastrointestinal tract

, 2011
Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
core   +1 more source

Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response [PDF]

, 2005
P2X2 receptor subunits of the ATP-gated ion channels are expressed by physiologically identified respiratory neurons in the ventral respiratory column, implicating ATP in the control of respiratory activity.
Spyer, K. Michael, Llaudet, E, Gourine, Alexander V., Spyer, KM, Dale, Nicholas, Llaudet, Enrique, Dale, N, Gourine, AV   +7 more
core   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Lalo, Ulyana, Pankratov, Yuriy, Verkhratsky, A. N. (Alekseĭ Nestorovich), Wichert, S., Kirchhoff, F., Rossner, Moritz J., Verkhratsky, Alexei; id_orcid, Kirchhoff, Frank, Verkhratsky, Alexei, Pankratov, Y., Rossner, M., Lalo, U., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), North, R., Pankratov, Yuri, North, R. Alan, Verkhratsky, A., Wichert, Sven P.   +17 more
core   +1 more source

Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

BMC Immunology, 2006
Background Epstein-Barr virus (EBV) infection immortalizes primary B cells in vitro and generates lymphoblastoid cell lines (LCLs), which are used for several purposes in immunological and genetic studies. Purinergic receptors, consisting of P2X and P2Y,
Kim Jun Woo, Kong In Deok, Park Kyu Sang, Lee Dong Hyeon, Han Bok Ghee   +4 more
doaj   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function

Frontiers in Physiology, 2022
Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When stressed, several cells, including endothelial cells, can release nucleotides like ATP and ADP that ...
Somasundaram Raghavan, Masuma Akter Brishti, Daniel Mohr Collier, M. Dennis Leo   +3 more
doaj   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Sympathetic nerve-derived ATP regulates renal medullary blood flow via vasa recta pericytes [PDF]

, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins. We have previously shown that exogenous ATP causes constriction of vasa
Peppiatt-Wildman, C. M., C. M. Peppiatt-Wildman, Scott S Wildman, C. Crawford, Wildman, Scott S.P., Kennedy-Lydon, T. M., M. C. Kelly, Wildman, S. S. P., Peppiatt-Wildman, Claire M., S. S. P. Wildman, T. M. Kennedy-Lydon, Kelly, M. C., Crawford, C.   +12 more
core   +1 more source