Results 61 to 70 of about 14,652 (181)

Neuroplasticity‐Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain

Brain and Behavior, Volume 16, Issue 4, April 2026.
The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong, Letai Li, Yanlin Li, Yutong Chen, Jiajie Leng, Tingting Chen   +5 more
wiley   +1 more source

P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction

Frontiers in Pharmacology, 2020
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Lucas T. Woods, Lucas T. Woods, Kimberly J. Jasmer, Kimberly J. Jasmer, Kevin Muñoz Forti, Kevin Muñoz Forti, Jean M. Camden, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman, Gary A. Weisman   +15 more
doaj   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Differences in localization of P2X7 during epithelial wound healing in pre-type II diabetic models [PDF]

, 2017
Corneal injury, accompanied by improper wound repair, is the 4th highest cause of preventable blindness according to the World Health Organization.
Kneer, Krisandra
core  

Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
Burnstock, G, King, B F, Spyer, K M, Thomas, T, Townsend-Nicholson, A, Wildman, Scott S.P.   +5 more
core   +1 more source

Effect of 40 Hz Light Stimulation on Calcium Dynamics of Astrocytes

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
40 Hz invisible spectral flickering (ISF) visible light stimulation and continuous light trigger calcium dynamics in primary astrocytes but recruit different signaling pathways. Astrocytes are glial cells with intracellular calcium dynamics essential for brain homeostasis, synaptic modulation, and cognition and altered in neuropathology and ...
Aikaterini Konstantoulaki, Maibritt Horning, Tjalfe Egholm Rude, Roberta Fabbri, Chiara Lazzarini, Giorgia Conte, Andrea Candini, Marco Caprini, Marcus Schultz Carstensen, Valentina Benfenati   +9 more
wiley   +1 more source

Sustained release of prostaglandin E2 in fibroblasts expressing ectopically cyclooxygenase 2 impairs P2Y-dependent Ca2+-mobilization [PDF]

, 1943
The nucleotide uridine trisphosphate (UTP) released to the extracellular milieu acts as a signaling molecule via activation of specific pyrimidine receptors (P2Y). P2Y receptors are G protein-coupled receptors expressed in many cell types.
Pimentel-Santillana, María, Través, Paqui G., Pérez-Sen, Raquel, Delicado, Esmerilda G., Martín-Sanz, Paloma, Miras-Portugal, María Teresa, Boscá, Lisardo   +6 more
core   +2 more sources

Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis

BioEssays, Volume 48, Issue 3, March 2026.
NLRP3, a cytosolic innate immune sensor, responds to diverse activators that perturb cellular homeostasis. These disturbances generate molecular scaffolds that, through binding partners such as nucleic acids, lipids, and proteins, recruit and concentrate NLRP3. Scaffold‐mediated NLRP3 clustering promotes NLRP3 inflammasome assembly.
Elvira Boršić‐Mlinarič, Iva Hafner‐Bratkovič   +1 more
wiley   +1 more source

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior. [PDF]

, 2015
The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all ...
Beamer, Edward, Bekő, Katinka, Gölöncsér, Flóra, Horváth, Gergely, Koványi, Bence, Otrokocsi, Lilla, Sperlágh, Beáta   +6 more
core   +1 more source

Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley   +1 more source