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Special Issue of International Journal of Molecular Sciences (IJMS) “Purinergic P2 Receptors: Structure and Function”

open access: yes, 2020
This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 ...
Hana Zemkova
core   +1 more source

Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]

open access: yes, 2002
The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas, Nicholas Dale
core   +1 more source

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation

open access: yesFrontiers in Pharmacology, 2019
Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space.
Linyu Wei   +8 more
doaj   +1 more source

Purinergic and glutamatergic interactions in the hypothalamic paraventricular nucleus modulate sympathetic outflow

open access: yes, 2013
P2X receptors are expressed on ventrolateral medulla projecting paraventricular nucleus (PVN) neurons. Here, we investigate the role of adenosine 5′-triphosphate (ATP) in modulating sympathetic nerve activity (SNA) at the level of the PVN.
Neto, Hildebrando Candido Ferreira   +2 more
core   +1 more source

Simultaneous Fluorescent Recordings of Extracellular ATP and Intracellular Calcium in Mammalian Cells

open access: yesBio-Protocol, 2019
Extracellular ATP is a potent signaling molecule that stimulates intracellular calcium responses through purinergic (P2) receptors in mammalian cells. While extracellular ATP and intracellular calcium can be measured separately, simultaneous monitoring ...
Nicholas Mikolajewicz, Svetlana Komarova
doaj   +1 more source

P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]

open access: yes, 1998
The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Webb, TE   +3 more
core  

Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures

open access: yes, 1998
To investigate potential trophic actions of extracellular ATP in human astrocytes, we have examined mitogenic signaling by purinergic receptors in cultures prepared from first trimester rostral central nervous system tissue. We found that ATP and ATP γS,
Micheline McCarthy   +7 more
core   +1 more source

Labeling and tracking P2 purinergic receptors in living cells using ATP-conjugated quantum dots

open access: yes, 2011
It has been increasingly recognized that adenosine-5 ′ -triphosphate (ATP) signaling through P2 purinergic receptors has a diverse infl uence on cell functions and human health.
Soo, Jianchow   +9 more
core   +1 more source

P2 receptors and immunity

open access: yes, 2012
Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on
DI VIRGILIO, Francesco   +2 more
core   +1 more source

The P2X receptor mediated regulation of inhibitory synaptic transmission [PDF]

open access: yes
In the central nervous system ATP can be released by neurons and glial cells through similar pathways as other neurotransmitters. Extracellular ATP targets P2X purinoreceptors, causing an influx of Ca2+ ions which transmit very important messages for ...
Andrew-Adiamah, Jemma
core  

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