Results 91 to 100 of about 14,652 (181)

Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice

Scientific Reports, 2018
The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Chun Yang, Andrei Larin, James T. McKenna, Kenneth A. Jacobson, Stuart Winston, Robert E. Strecker, Anna Kalinchuk, Radhika Basheer, Ritchie E. Brown   +8 more
doaj   +1 more source

An emerging role for adenosine and its receptors in bone homeostasis

Frontiers in Endocrinology, 2012
Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans, Bronwen eEvans, Jack eHam, Jack eHam   +3 more
doaj   +1 more source

The role of dinucleoside polyphosphates on the ocular surface and other eye structures [PDF]

, 2016
Dinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present
Carracedo Rodríguez, Juan Gonzalo, Crooke, Almudena, Guzmán Aranguez, Ana María, Pintor, Jesús   +3 more
core   +1 more source

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation

Frontiers in Pharmacology, 2019
Organs and tissues and their constituent cells are physiologically submitted to diverse types of mechanical forces or stress, one common sequence of which is release of intracellular ATP into extracellular space.
Linyu Wei, Fatema Mousawi, Dongliang Li, Sébastien Roger, Jing Li, Xuebin Yang, Lin-Hua Jiang, Lin-Hua Jiang, Lin-Hua Jiang   +8 more
doaj   +1 more source

Simultaneous Fluorescent Recordings of Extracellular ATP and Intracellular Calcium in Mammalian Cells

Bio-Protocol, 2019
Extracellular ATP is a potent signaling molecule that stimulates intracellular calcium responses through purinergic (P2) receptors in mammalian cells. While extracellular ATP and intracellular calcium can be measured separately, simultaneous monitoring ...
Nicholas Mikolajewicz, Svetlana Komarova
doaj   +1 more source

Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy

Journal of Inflammation Research, 2021
Tobias Engel,1,2,* Jonathon Smith,1,2,* Mariana Alves1 1Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland; 2FutureNeuro, Science Foundation ...
Engel T, Smith J, Alves M
doaj  

Antidipsogenic effects of central adenosine-5'-triphosphate

Brazilian Journal of Medical and Biological Research, 2009
Besides other physiological functions, adenosine-5'-triphosphate (ATP) is also a neurotransmitter that acts on purinergic receptors. In spite of the presence of purinergic receptors in forebrain areas involved with fluid-electrolyte balance, the effect ...
D.R.G. de Faria, J.S. Santana, J.V. Menani, P.M. de Paula   +3 more
doaj  

Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis?

Journal of Innate Immunity
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Luke Forde, Debananda Gogoi, Rory Baird, Cormac McCarthy, Michael P. Keane, Emer P. Reeves, Emmet E. McGrath   +6 more
doaj   +1 more source

Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin

Pathogens
Clostridium perfringens alpha toxin (CPA), which causes yellow lamb disease in sheep and gas gangrene and food poisoning in humans, is produced by all types of C. perfringens and is the major virulence determinant of C. perfringens type A.
Zishuo Guo, Nan Yue, Ming Chen, Jiaxin Li, Ruomei Lv, Jing Wang, Tingting Liu, Jing Huang, Shan Gao, Yanwei Li, Bing Yuan, Jinglin Wang, Lin Kang, Bin Ji, Wenwen Xin   +14 more
doaj   +1 more source

In vitro functional properties of the rat bladder regenerated by the bladder acellular matrix graft. [PDF]

, 1998
PurposeTo assess the response of rat urinary bladder regenerated by the homologous bladder acellular matrix graft (BAMG) to in vitro electrical and pharmacologic stimuli.Materials and methodsIn Sprague-Dawley rats, partial cystectomy (>50%) was ...
Dahiya, R, Dahms, SE, Lue, TF, Nunes, LS, Piechota, HJ, Tanagho, EA   +5 more
core   +1 more source