Results 101 to 110 of about 28,114 (251)
, 2020 This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 ...
Hana Zemkova
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International Journal of Molecular Sciences, 2020 Background: Human mesenchymal stem cells (hMSCs) have shown their multipotential including differentiating towards endothelial and smooth muscle cell lineages, which triggers a new interest for using hMSCs as a putative source for cardiovascular ...
Yu Zhang +4 more
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Purinergic ATP‐P2X7 Signaling Drives Colonic Giant Migrating Contraction in Suncus murinus
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Using Suncus murinus, this study reveals that ATP regulates colonic giant migrating contractions (GMCs). ATP activates P2X7 receptors on cholinergic neurons, triggering powerful contractions that facilitate defecation. This effect is suppressed by P2X7 receptor antagonists and atropine, identifying the ATP‐P2X7‐acetylcholine axis as a key regulatory ...
Ayano Gomi +2 more
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, 2013 P2X receptors are expressed on ventrolateral medulla projecting paraventricular nucleus (PVN) neurons. Here, we investigate the role of adenosine 5′-triphosphate (ATP) in modulating sympathetic nerve activity (SNA) at the level of the PVN.
Neto, Hildebrando Candido Ferreira +2 more
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Frontiers in Cellular Neuroscience, 2015 Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 for nucleotides, they are ...
Fabio eCavaliere +2 more
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P2 purinergic receptors on osteoblasts and osteoclasts: Potential targets for drug development
Drug Development Research, 2000 Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization and influx of Ca2+, whereas the P2Y receptor subtypes couple through G proteins to activation of phospholipase Cβ and mobilization of intracellular Ca2+. In nonskeletal
Dixon, S. Jeffrey, Sims, Stephen M.
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, 1998 To investigate potential trophic actions of extracellular ATP in human astrocytes, we have examined mitogenic signaling by purinergic receptors in cultures prepared from first trimester rostral central nervous system tissue. We found that ATP and ATP γS,
Micheline McCarthy +7 more
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Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta
European Journal of Histochemistry, 2009 Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/ CD39) is the dominant ecto-nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type-2 purinergic (P2) Gprotein coupled receptors (GPCRs).
A Kittel +4 more
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Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]
, 2000 Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
B. F. King +17 more
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Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]
, 2008 Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Dale, Nicholas, Wall, Mark J.
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