Results 31 to 40 of about 28,114 (251)

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M., Peppiatt-Wildman, C. M., Wildman, S. S., R. E. Birch, C. M. Peppiatt-Wildman, Scott S Wildman, Schwiebert, E. M., Wildman, Scott S.P., E. M. Schwiebert, S. S. Wildman, Birch, R. E.   +10 more
core   +1 more source

Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia

Frontiers in Physiology, 2023
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors.
Byeong J. Chun, Surya P. Aryal, Peter Varughese, Bin Sun, Joshua A. Bruno, Chris I. Richards, Adam D. Bachstetter, Peter M. Kekenes-Huskey   +7 more
doaj   +1 more source

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
B. F. King, H. Kim, Ji, Xiao-Duo, Camaioni, Emidio, King, Brian F., A. Rychkov, A. Bartolini, Boyer, Jos L., Waktolla, GF, Mohanram, Arvind, F. Giuliani, K. A. Jacobson, Jacobson, Kenneth A., Y. C. Kim, Burnstock, Geoffrey, Park, HS, J. L. Boyer, Ziganshin, Airat U., S. S. Wildman, Harden, T. Kendall, Yoburn, Joshua, N. Galeotti, Galeotti, Nicoletta, Kass, GEN, A. U. Ziganshin, J.o. Yoburn, Sarkardei, S, C. Ghelardini, Tennant, JP, Wildman, Scott S.P., Rychkov, Alexei, T. K. Harden, G. Burnstock, Kim, Heaok, D. Barlocco, Bartolini, Alessandro, Kim, Yong-Chul, Boyer, José L., Ghelardini, Carla, Wildman, Scott S., Hourani, SMO, A. Mohanram, X. D. Ji   +42 more
core   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
core   +1 more source

P2 purinergic receptor modulation of cytokine production [PDF]

Purinergic Signalling, 2007
Cytokines serve important functions in controlling host immunity. Cells involved in the synthesis of these polypeptide mediators have evolved highly regulated processes to ensure that production is carefully balanced. In inflammatory and immune disorders, however, mis-regulation of the production and/or activity of cytokines is recognized as a major ...
openaire   +2 more sources

Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders

Frontiers in Pharmacology, 2017
Extracellular nucleosides and nucleotides, such as adenosine and adenosine triphosphate (ATP), are involved in many physiological and pathological processes in adipose tissue (AT).
Marco Tozzi, Ivana Novak
doaj   +1 more source

P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review

Frontiers in Oncology, 2021
Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear.
Yonglin Mai, Zhihua Guo, Weiqiang Yin, Nanshan Zhong, Peter V. Dicpinigaitis, Ruchong Chen   +5 more
doaj   +1 more source

Physiologic roles of P2 receptors in leukocytes

Journal of Leukocyte Biology, 2022
Since their discovery in the 1970s, purinergic receptors have been shown to play key roles in a wide variety of biologic systems and cell types. In the immune system, purinergic receptors participate in innate immunity and in the modulation of the ...
A. P. Alberto, Natiele Carla da Silva Ferreira, A. Bonavita, O. K. Nihei, F. P. de Farias, R. D. Bisaggio, C. de Albuquerque, W. Savino, R. Coutinho-Silva, P. Persechini, L. A. Alves   +10 more
semanticscholar   +1 more source

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors

Virulence, 2018
Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao, Wenwen Xin, Jing Huang, Bin Ji, Shan Gao, Liang Chen, Lin Kang, Hao Yang, Xin Shen, Baohua Zhao, Jinglin Wang   +10 more
doaj   +1 more source

Communication between Corneal Epithelial Cells and Trigeminal Neurons Is Facilitated by Purinergic (P2) and Glutamatergic Receptors

PLoS ONE, 2012
Previously, we demonstrated that nucleotides released upon mechanical injury to corneal epithelium activate purinergic (P2) receptors resulting in mobilization of a Ca2+ wave.
D. Oswald, Albert Lee, Monique L. Trinidad, Cheryl Chi, Ruiyi Ren, C. Rich, V. Trinkaus-Randall   +6 more
semanticscholar   +1 more source