Results 11 to 20 of about 28,114 (251)
Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus [PDF]
International Journal of Molecular Sciences, 2021 ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and pathophysiological ...
J. Lommen +4 more
semanticscholar +4 more sources
Purinergic P2 Receptors: Structure and Function 2.0
International Journal of Molecular Sciences, 2023 This Special Issue of the International Journal of Molecular Sciences (IJMS) is a direct continuation of the previous Special Issue of this journal, entitled “Purinergic P2 Receptors: Structure and Function” https://www [...]
Hana Zemkova
openaire +3 more sources
Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes [PDF]
Molecules, 2022 Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato +9 more
doaj +3 more sources
P2 purinergic receptor dysregulation in urologic disease
Purinergic Signalling, 2022 P2 purinergic receptors are involved in the normal function of the kidney, bladder, and prostate via signaling that occurs in response to extracellular nucleotides.
Janielle P. Maynard, K. Sfanos
semanticscholar +3 more sources
Altered Purinergic Signaling in Neurodevelopmental Disorders: Focus on P2 Receptors
Biomolecules, 2023 With the umbrella term ‘neurodevelopmental disorders’ (NDDs) we refer to a plethora of congenital pathological conditions generally connected with cognitive, social behavior, and sensory/motor alterations.
Marta Boccazzi +4 more
doaj +4 more sources
American Journal of Physiology-Renal Physiology, 2013 In addition to its role as a physical barrier, the urothelium is considered to play an active role in mechanosensation. A key mechanism is the release of transient mediators that activate purinergic P2 receptors and transient receptor potential (TRP ...
Saqib Shabir +7 more
semanticscholar +4 more sources
Purinergic signalling: past, present and future
Brazilian Journal of Medical and Biological Research, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock
doaj +1 more source
Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity
Frontiers in Pharmacology, 2018 Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis.
Milka Koupenova, Katya Ravid
doaj +2 more sources
Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice [PDF]
Scientific Reports, 2018 The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness,
Chun Yang +8 more
doaj +3 more sources
Frontiers in Endocrinology, 2022 Diabetes Mellitus is a metabolic disorder characterized by a chronic hyperglycemia due to an impaired insulin secretion and a decreased in peripheral insulin sensitivity. This disease is a major public health problem due to it sharp prevalence. Therefore,
Nour Mesto +2 more
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