Results 31 to 40 of about 16,178 (230)
Virology Journal, 2011 Hepatitis C virus (HCV) is a major health problem in developing countries including Pakistan. Chronic HCV infection results in progressive liver disease including fibrosis, cirrhosis, insulin resistance and eventually hepatocellular carcinoma (HCC ...
Fatima Kaneez +8 more
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Subunit Arrangement in P2X Receptors [PDF]
The Journal of Neuroscience, 2003 ATP-gated ionotropic receptors (P2X receptors) are distributed widely in the nervous system. For example, a hetero-oligomeric receptor containing both P2X2and P2X3subunits is involved in primary afferent sensation. Each subunit has two membrane-spanning domains.
Jiang, Lin Hua +5 more
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Cellular Physiology and Biochemistry, 2016 Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF).
Jihong Xing, Jianhua Li
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An evolutionary history of P2X receptors [PDF]
Purinergic Signalling, 2008 Adenosine triphosphate (ATP) is an ancient and fundamentally important biological molecule involved in both intracellular and extracellular activities. P2X ionotropic and P2Y metabotropic receptors have been cloned and characterised in mammals. ATP plays a central physiological role as a transmitter molecule in processes including the sensation of pain,
Fountain, Samuel J., Burnstock, Geoffrey
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Age-dependent remodelling of ionotropic signalling in cortical astroglia [PDF]
, 2011 Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial.
Lalo, Ulyana +11 more
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Molecular Pain, 2010 Background To evaluate whether P2X receptors are involved in responses to noxious pulp stimulation, the P2X3 and P2X2/3 receptor agonist α,β-methyleneATP (α,β-meATP) was applied to the molar tooth pulp and nocifensive behavior and extracellular-signal ...
Sessle Barry J +10 more
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Current Biology, 2004 What are they? P2X channels are a family of cell-membrane cation channels which open within milliseconds of binding ATP. They are distinct from the other family of ATP receptors, the G-protein-coupled P2Y receptors, and also from other transmitter-gated ion channels.
Girdler, Gemma, Khakh, Baljit S
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The trafficking and targeting of P2X receptors [PDF]
Frontiers in Cellular Neuroscience, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties.
Robinson, Lucy E. +1 more
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The role of the P2X₇ receptor in infectious diseases.
PLoS Pathogens, 2011 ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines.
Catherine M Miller +7 more
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Post-translational regulation of P2X receptor channels: modulation by phospholipids
Frontiers in Cellular Neuroscience, 2013 P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response.
Louis-Philippe eBernier +2 more
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