Polyunsaturated fatty acids modify the gating of Kv channels [PDF]
Frontiers in Pharmacology, 2012 Polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which are attributed to their capability to modulate ion channels.
Cristina eMoreno +4 more
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Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]
PLoS ONE, 2013 In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk +5 more
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MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter [PDF]
Communications Biology, 2018 Through a MicroED structure of NaK ion channel, Shian Liu and Tamir Gonen identify a process of dilation coupled with Na+ movement, providing mechanistic insights into ion conduction and gating.
Shian Liu, Tamir Gonen
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Similarity of the ion occupations of K+ and Tl+ in the selectivity filter of a K+ channel, as verified by single-channel currents [PDF]
ChannelsVoltage-dependent gating in the selectivity filter of potassium channels is modulated by the permeating ions binding within the filter. In the viral Kcv channel, filter gating occurs on the sub-millisecond time scale.
Lena Diederich +3 more
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PLoS Computational Biology, 2010 Neuronal activity is mediated through changes in the probability of stochastic transitions between open and closed states of ion channels. While differences in morphology define neuronal cell types and may underlie neurological disorders, very little is ...
Robert C Cannon +2 more
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Voltage-dependent gating in a "voltage sensor-less" ion channel.
PLoS Biology, 2010 The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata +4 more
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Information Entropy Metrics to Address the Complexity of Cooperative Gating of Ion Channels [PDF]
EntropyIon channels in biological membranes can form spatially localized clusters that exhibit cooperative gating behavior. In this mode, the activity of one channel modulates the opening probability of its neighbors.
Agata Wawrzkiewicz-Jałowiecka +3 more
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Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells [PDF]
Advanced ScienceThe inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair bundles into electrical signals. The mechanical correlates of channel gating—the gating force and the gating swing—are fundamental determinants of hair ...
Achille Joliot +2 more
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Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter [PDF]
eLifeBig-conductance, Ca²+-activated K+ (BK) channels consist of Ca²+- and voltage-sensing, pore-forming α (BKα) subunits and regulatory auxiliary β or γ subunits. Concatenated subunit constructs are powerful tools for elucidating subunit stoichiometry in ion
Guanxing Chen +3 more
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Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor
eLife, 2021 Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by ...
John R Strikwerda, Steven M Sine
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