Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
eLife, 2019 TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an NAD+-metabolite produced under oxidative stress and neurodegenerative
Yihe Huang, Becca Roth, Wei Lü, Juan Du
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Sodium channel inactivation kinetics of rat sensory and motor nerve fibres and their modulation by glutathione [PDF]
, 1993 Na+ channel currents of rat motor and sensory nerve fibres were studied with the patch-clamp technique on enzymatically demyelinated axons. Differences between motor and sensory fibres in multi-channel inactivation kinetics and the gating of late single ...
Quasthoff, Stefan +2 more
core +1 more source
The ligand gated ion channel database [PDF]
Nucleic Acids Research, 1999 The ligand gated ion channels (LGICs) are ionotropic receptors to neurotransmitters. Their physiological effect is carried out by the opening of an ionic channel upon binding of a particular neurotransmitter. These LGICs constitute superfamilies of receptors formed by homologous subunits.
Nicolas Le Novère, Jean-Pierre Changeux
openaire +2 more sources
Piezo’s membrane footprint and its contribution to mechanosensitivity
eLife, 2018 Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation.
Christoph A Haselwandter +1 more
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An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
Advanced Science, 2020 While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or ...
Fan Yang +5 more
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Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]
PLoS Biology, 2013 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti +9 more
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The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]
, 2007 We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J. +14 more
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A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
Nature Communications, 2018 Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions.
Yue Sun +9 more
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Polyunsaturated fatty acids modify the gating of Kv channels
Frontiers in Pharmacology, 2012 Polyunsaturated fatty acids (PUFAs) have been reported to exhibit antiarrhythmic properties, which are attributed to their capability to modulate ion channels.
Cristina eMoreno +4 more
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Optical control of PIEZO1 channels
Nature Communications, 2023 PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta +8 more
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