Results 11 to 20 of about 99,152 (293)
Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
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Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating [PDF]
, 2016 The flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively, shedding light on the mechanisms underlying gating.
A Tinker +38 more
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The gates of ion channels and enzymes [PDF]
Trends in Biochemical Sciences, 2010 Protein dynamics are essential for virtually all protein functions, certainly for gating mechanisms of ion channels and regulation of enzyme catalysis. Ion channels usually feature a gate in the channel pore that prevents ion permeation in the closed state.
unknown ( host institution ) +1 more
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Nature Communications, 2022 Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel ...
Xiaolong Gao +6 more
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Central cavity dehydration as a gating mechanism of potassium channels
Nature Communications, 2023 The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity, rather than a physical occlusion of the nanopore, functions in various ion channels including potassium channels.
Ruo-Xu Gu, Bert L. de Groot
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Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]
PLoS ONE, 2011 We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
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Ion channels gated by heat [PDF]
Proceedings of the National Academy of Sciences, 1999 All animals need to sense temperature to avoid hostile environments and to regulate their internal homeostasis. A particularly obvious example is that animals need to avoid damagingly hot stimuli. The mechanisms by which temperature is sensed have until recently been mysterious, but in the last couple of years, we have begun to understand how ...
Cesare P. +3 more
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Interplay between Gating and Block of Ligand-Gated Ion Channels
Brain Sciences, 2020 Drugs that inhibit ion channel function by binding in the channel and preventing current flow, known as channel blockers, can be used as powerful tools for analysis of channel properties.
Matthew B. Phillips +2 more
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Frontiers in Cell and Developmental Biology, 2022 The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion channels that transduce mechanical stimuli with high sensitivity and speed. This conversion process is usually called mechanotransduction.
Yu-Chia Chuang +3 more
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A new polymodal gating model of the proton-activated chloride channel.
PLoS Biology, 2023 The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304.
Piao Zhao +13 more
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