Results 1 to 10 of about 948,798 (150)

A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3 [PDF]

Communications Chemistry
Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception.
Katharina Held, Evelien Van Hoeymissen, Ilhem Dallali, Eleonora Persoons, Bahar Bazeli, Robbe Roelens, Stijn Robben, Caroline Wuyts, Marie Mulier, Silvia Pinto, Annelies Janssens, Thomas Voets, Joris Vriens   +12 more
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Ca2+-activated Cl− channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells

Journal of Advanced Research, 2021
Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao   +10 more
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Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis

Journal of Advanced Research, 2021
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao   +13 more
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Continuous glucose monitoring during pregnancy in healthy mice

Scientific Reports, 2021
During pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops.
Caroline Wuyts, Caroline Simoens, Silvia Pinto, Koenraad Philippaert, Rudi Vennekens   +4 more
doaj   +1 more source

TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

Journal of Advanced Research, 2020
TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghua Wang, Lichuan Bai, Shuya Luo, Tianyu Wang, Fan Yang, Jialin Xia, Hui Wang, Ke Ma, Mei Liu, Shuwei Wu, Huijie Wang, Shibin Guo, Xiaohong Sun, Qinghuan Xiao   +13 more
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Triggering the Amphotericin B Pore-Forming Activity by Phytochemicals

Membranes, 2023
The macrolide polyene antibiotic amphotericin B (AmB), remains a valuable drug to treat systemic mycoses due to its wide antifungal activity and low probability of developing resistance.
Svetlana S. Efimova, Anna I. Malykhina, Olga S. Ostroumova   +2 more
doaj   +1 more source

Intracellular pH Control by Membrane Transport in Mammalian Cells. Insights Into the Selective Advantages of Functional Redundancy

Frontiers in Molecular Biosciences, 2022
Intracellular pH is a vital parameter that is maintained close to neutrality in all mammalian cells and tissues and acidic in most intracellular compartments.
Denis Doyen, Denis Doyen, Denis Doyen, Mallorie Poët, Mallorie Poët, Gisèle Jarretou, Gisèle Jarretou, Didier F. Pisani, Didier F. Pisani, Michel Tauc, Michel Tauc, Marc Cougnon, Marc Cougnon, Mederic Argentina, Yann Bouret, Laurent Counillon, Laurent Counillon   +16 more
doaj   +1 more source

Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model [PDF]

, 2004
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model.
Chow C C, Clay J R, DeFelice L J, Fox R F, G Schmid, Gammaitoni L, Goldman M S, Hille B, Hodgkin A L, Hänggi P, Hänggi P, I Goychuk, Lecar H, LeMasson G, P Hänggi, Press W H, Skaugen E, Strassberg A F   +17 more
core   +2 more sources

Definition of two agonist types at the mammalian cold-activated channel TRPM8

eLife, 2016
Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens, Maarten Gees, Balazs Istvan Toth, Debapriya Ghosh, Marie Mulier, Rudi Vennekens, Joris Vriens, Karel Talavera, Thomas Voets   +8 more
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Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury

Frontiers in Cardiovascular Medicine, 2023
BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption ...
Viviana Delgado-Betancourt, Viviana Delgado-Betancourt, Kroekkiat Chinda, Kroekkiat Chinda, Pietro Mesirca, Pietro Mesirca, Christian Barrère, Christian Barrère, Aurélie Covinhes, Aurélie Covinhes, Laura Gallot, Laura Gallot, Anne Vincent, Anne Vincent, Isabelle Bidaud, Isabelle Bidaud, Sarawut Kumphune, Joël Nargeot, Joël Nargeot, Christophe Piot, Christophe Piot, Christophe Piot, Kevin Wickman, Matteo Elia Mangoni, Matteo Elia Mangoni, Stéphanie Barrère-Lemaire, Stéphanie Barrère-Lemaire   +26 more
doaj   +1 more source