Results 31 to 40 of about 312,333 (268)

Lipid ion channels [PDF]

Biophysical Chemistry, 2010
Review
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The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

eLife, 2016
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca2+-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death.
Iordan Iordanov, Csaba Mihályi, Balázs Tóth, László Csanády   +3 more
doaj   +1 more source

Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition

Pharmaceutical Biology, 2020
Context Ginsenoside Rb1, the main active ingredient of ginseng, exhibits ex vivo depression of store-operated calcium entry (SOCE) and related vasoconstriction in pulmonary arteries derived from pulmonary hypertension (PH) rats.
Rui-Xing Wang, Rui-Lan He, Hai-Xia Jiao, Run-Tian Zhang, Jing-Yi Guo, Xiao-Ru Liu, Long-Xin Gui, Mo-Jun Lin, Zhi-Juan Wu   +8 more
doaj   +1 more source

How Does Our Knowledge on the Na+/H+ Exchanger NHE1 Obtained by Biochemical and Molecular Analyses Keep up With Its Recent Structure Determination?

Frontiers in Physiology, 2022
Na+/H+ exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells.
Mallorie Poet, Mallorie Poet, Denis Doyen, Denis Doyen, Denis Doyen, Emmanuel Van Obberghen, Emmanuel Van Obberghen, Emmanuel Van Obberghen, Gisèle Jarretou, Gisèle Jarretou, Yann Bouret, Laurent Counillon, Laurent Counillon   +12 more
doaj   +1 more source

Ion channels and ion selectivity [PDF]

Essays in Biochemistry, 2017
Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
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Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

eLife, 2019
Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov, Balázs Tóth, Andras Szollosi, László Csanády   +3 more
doaj   +1 more source

The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na_V1.5 Mutant of the Long QT Type 3 Syndrome

Biomolecules, 2020
Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti ...
Julio Alvarez-Collazo, Alejandro López-Requena, Julio L. Alvarez, Karel Talavera   +3 more
doaj   +1 more source

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

eLife, 2023
CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings.
Márton A Simon, Iordan Iordanov, Andras Szollosi, László Csanády   +3 more
doaj   +1 more source

Ion channel activity drives ion channel expression [PDF]

The Journal of Physiology, 1998
During embryonic development, excitable cells acquire a repertoire of ion channels that finely tune their electrical properties. Although the mechanisms by which an excitable cell selects its complement of ion channels are poorly defined, cell-autonomous as well as non-autonomous programmes of differentiation have been implicated.
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Ion Channels of Nociception [PDF]

International Journal of Molecular Sciences, 2020
The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes, nociceptive roles of P2X3, ASIC, Piezo and TRP ...
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