Results 31 to 40 of about 948,947 (298)
Frontiers in Physiology, 2022 Na+/H+ exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells.
Mallorie Poet +12 more
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Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]
, 2019 TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W +4 more
core +2 more sources
Ion channels and ion selectivity [PDF]
Essays in Biochemistry, 2017 Specific macromolecular transport systems, ion channels and pumps, provide the pathways to facilitate and control the passage of ions across the lipid membrane. Ion channels provide energetically favourable passage for ions to diffuse rapidly and passively according to their electrochemical potential.
openaire +2 more sources
eLife, 2019 Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology
Iordan Iordanov +3 more
doaj +1 more source
Biomolecules, 2020 Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti ...
Julio Alvarez-Collazo +3 more
doaj +1 more source
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
eLife, 2023 CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings.
Márton A Simon +3 more
doaj +1 more source
Channel Optical Waveguides and Directional Couplers in GaAs -- Imbedded and Ridged [PDF]
, 1973 Two-channel imbedded directional couplers were fabricated with proton implantation, yielding complete light transfer in 2 mm. Ridged channel guides were fabricated by ion-micromachining epitaxial layers, and a method of directional coupling was ...
Garmire, E. +4 more
core +2 more sources
Ion channel activity drives ion channel expression [PDF]
The Journal of Physiology, 1998 During embryonic development, excitable cells acquire a repertoire of ion channels that finely tune their electrical properties. Although the mechanisms by which an excitable cell selects its complement of ion channels are poorly defined, cell-autonomous as well as non-autonomous programmes of differentiation have been implicated.
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Ion Channels of Nociception [PDF]
International Journal of Molecular Sciences, 2020 The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain. The content covers the mechanisms of neuropathic, inflammatory, and dental pain as well as pain in migraine and diabetes, nociceptive roles of P2X3, ASIC, Piezo and TRP ...
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Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization
eLife, 2016 In CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, ATP-binding-induced dimerization of two cytosolic nucleotide binding domains (NBDs) opens the pore, and dimer disruption following ATP hydrolysis closes it.
Csaba Mihályi +2 more
doaj +1 more source