Results 1 to 10 of about 256,495 (250)
Sodium channels and pain [PDF]
Proceedings of the National Academy of Sciences, 1999 Although it is well established that hyperexcitability and/or increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability ...
S G, Waxman +3 more
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Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
Frontiers in Pharmacology, 2022 Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels.
Goragot Wisedchaisri +1 more
doaj +1 more source
Channels, 2023 One of nature’s exceptions was discovered when a Cav3 T-type channel was observed to switch phenotype from a calcium channel into a sodium channel by neutralizing an aspartate residue in the high field strength (HFS) +1 position within the ion ...
J. David Spafford
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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
core +1 more source
DDESC: Dragon database for exploration of sodium channels in human
BMC Genomics, 2008 Background Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as ...
Radovanovic Aleksandar +7 more
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Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]
, 1992 The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
B Neumcke +15 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005 We have explored the permeation and blockage of ions in sodium channels, relating the channel structure to function using electrostatic profiles and Brownian dynamics simulations. The model used resembles the KcsA potassium channel with an added external vestibule and a shorter selectivity filter.
Vora, Taira, Corry, Ben, Chung, Shin-Ho
openaire +3 more sources
Studies of alpha-helicity and intersegmental interactions in voltage-gated Na+ channels: S2D4. [PDF]
PLoS ONE, 2009 Much data, including crystallographic, support structural models of sodium and potassium channels consisting of S1-S4 transmembrane segments (the "voltage-sensing domain") clustered around a central pore-forming region (S5-S6 segments and the intervening
Zhongming Ma, Jun Kong, Roland G Kallen
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SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]
, 2016 The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An +2 more
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Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]
, 2013 Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai +44 more
core +3 more sources