Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review [PDF]
Journal of Cannabis ResearchBackground Voltage-gated sodium channels regulate dorsal root ganglion excitability and are critical for nociceptive transmission. Cannabidiol (CBD) and related phytocannabinoids have been proposed to modulate these channels, offering potential non ...
Samuel Gonçalves Castro +3 more
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels. [PDF]
PLoS ONE, 2013 NALCN is a member of the family of ion channels with four homologous, repeat domains that include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene from simple, extant multicellular organisms without nervous systems such as ...
Adriano Senatore +4 more
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Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA
Marine Drugs, 2019 µ-Conotoxin PIIIA, in the sub-picomolar, range inhibits the archetypal bacterial sodium channel NaChBac (NavBh) in a voltage- and use-dependent manner.
Rocio K. Finol-Urdaneta +8 more
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Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
Frontiers in Pharmacology, 2012 Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi-spanning integral membrane glycoprotein (α-subunit) that can be associated ...
Eleonora eSavio Galimberti +2 more
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Voltage-gated sodium channels in cancers [PDF]
Biomarker ResearchVoltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate ...
Hengrui Liu +3 more
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VOLTAGE-GATED SODIUM CHANNELS AND CANCER: IS EXCITABILITY THEIR PRIMARY ROLE?
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels (NaV) are molecular characteristics of excitable cells. Their activation, triggered by membrane depolarization, generates transient sodium currents that initiate action potentials in neurons and muscle cells. Sodium currents
Sébastien eRoger +3 more
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Sodium channels as a new target for pain treatment [PDF]
Frontiers in PharmacologyChen R +6 more
exaly +2 more sources
Effects of Electrical Remodeling on Atrial Fibrillation in Diabetes Mellitus
Reviews in Cardiovascular Medicine, 2023 Atrial fibrillation (AF) is one of the most common arrhythmias in medical practice. Diabetes mellitus (DM) is one of the independent risk factors for atrial fibrillation.
Ling-ling Qian +4 more
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Fenestropathy of Voltage-Gated Sodium Channels
Frontiers in Pharmacology, 2022 Voltage-gated sodium channels (Nav) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these integral membrane proteins are the ignition stations for every sensation and action in human ...
Tamer M. Gamal El-Din +2 more
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