Results 1 to 10 of about 260,312 (303)
Brain and Neuroscience Advances, 2018 In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed Na V 1.1–Na V 1.9.
John N. Wood, Federico Iseppon
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Excitability constraints on voltage-gated sodium channels. [PDF]
PLoS Computational Biology, 2007 We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
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Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review [PDF]
Journal of Cannabis ResearchBackground Voltage-gated sodium channels regulate dorsal root ganglion excitability and are critical for nociceptive transmission. Cannabidiol (CBD) and related phytocannabinoids have been proposed to modulate these channels, offering potential non ...
Samuel Gonçalves Castro +3 more
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NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels. [PDF]
PLoS ONE, 2013 NALCN is a member of the family of ion channels with four homologous, repeat domains that include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene from simple, extant multicellular organisms without nervous systems such as ...
Adriano Senatore +4 more
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Voltage-gated sodium channels in cancers [PDF]
Biomarker ResearchVoltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate ...
Hengrui Liu +3 more
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Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels [PDF]
Frontiers in Physiology, 2015 Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH +1 more
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Amiloride-Sensitive Sodium Channels and Pulmonary Edema [PDF]
Pulmonary Medicine, 2011 The development of pulmonary edema can be considered as a combination of alveolar flooding via increased fluid filtration, impaired alveolar-capillary barrier integrity, and disturbed resolution due to decreased alveolar fluid clearance.
Mike Althaus +2 more
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Sodium channels and mammalian sensory mechanotransduction [PDF]
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
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Frontiers in Pharmacology, 2023 During the second half of the last century, the prevalent knowledge recognized the voltage-gated sodium channels (VGSCs) as the proteins responsible for the generation and propagation of action potentials in excitable cells.
Ana Laura Sanchez-Sandoval +3 more
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VOLTAGE-GATED SODIUM CHANNELS AND CANCER: IS EXCITABILITY THEIR PRIMARY ROLE?
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels (NaV) are molecular characteristics of excitable cells. Their activation, triggered by membrane depolarization, generates transient sodium currents that initiate action potentials in neurons and muscle cells. Sodium currents
Sébastien eRoger +3 more
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