Results 1 to 10 of about 331,376 (161)

How Sodium and Calcium Ions Pass Through Batrachotoxin-Bound Sodium Channel [PDF]

Toxins
Steroidal sodium channel agonist batrachotoxin (BTX), one of the most potent animal toxins, dramatically increases calcium permeation and alters other channel characteristics.
Boris S. Zhorov
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Molecular basis of sodium channel inactivation [PDF]

Nature Communications
Voltage-gated sodium channels initiate action potentials and control electrical signaling throughout the animal kingdom. Fast inactivation is an essential auto-inhibitory mechanism and requisite component of sodium channel physiology.
Yichen Liu, Jason D. Galpin, Christopher A. Ahern, Francisco Bezanilla   +3 more
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The Cardiac Sodium Channel Safety Profile of Cenobamate at Therapeutic Concentrations: In Vitro Analyses [PDF]

Clinical and Translational Science
The US Food and Drug Administration (FDA) issued a Drug Safety Communication for the antiseizure drug lamotrigine (Lamictal), warning of the risk of QRS prolongation and cardiac arrhythmias.
William J. Crumb Jr, Susan M. Melnick, Kelli J. Glenn   +2 more
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Sodium Channel mRNA Binding Proteins [PDF]

JACC: Basic to Translational Science
Barry London, MD, PhD
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Detection of Deltamethrin resistance level and association between sodium channel domain III gene mutation sites and drug resistance of Rhipicephalus microplus [PDF]

Open Life Sciences
To investigate the level of Deltamethrin resistance and mutation sites in the sodium iron channel gene in Rhipicephalus microplus (R. microplus) in Huaihua City, Hunan Province, and to examine the correlation between Deltamethrin resistance and mutation ...
Li Zhong-Bo, Duan Liangxin, Liu Xin, Yang Tian, Hu Hui, Xiang Min, Huang Cui-qin   +6 more
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Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

BMC Neurology, 2021
Background Many antiseizure medications (ASMs) control seizures by blocking voltage-dependent sodium channels. Polymorphisms of sodium channel genes may affect the response to ASMs due to altering the effect of ASMs on blocking sodium channels.
Chih-Hsiang Lin, Chen-Jui Ho, Yan-Ting Lu, Meng-Han Tsai   +3 more
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Sodium channels [PDF]

Brain and Neuroscience Advances, 2018
In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed Na V 1.1–Na V 1.9.
Wood, JN, Iseppon, F
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Highly Sensitive and Selective Sodium Ion Sensor Based on Silicon Nanowire Dual Gate Field-Effect Transistor

Sensors, 2021
In this study, a highly sensitive and selective sodium ion sensor consisting of a dual-gate (DG) structured silicon nanowire (SiNW) field-effect transistor (FET) as the transducer and a sodium-selective membrane extended gate (EG) as the sensing unit was
Seong-Kun Cho, Won-Ju Cho
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Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy

Frontiers in Neuroscience, 2023
Developmental and epileptic encephalopathies (DEEs) are severe seizure disorders with inadequate treatment options. Gain- or loss-of-function mutations of neuronal ion channel genes, including potassium channels and voltage-gated sodium channels, are ...
Sophie F. Hill, Sophie F. Hill, Paymaan Jafar-Nejad, Frank Rigo, Miriam H. Meisler, Miriam H. Meisler, Miriam H. Meisler   +6 more
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Sodium channels and pain [PDF]

Proceedings of the National Academy of Sciences, 1999
Although it is well established that hyperexcitability and/or increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability ...
S G, Waxman, S, Dib-Hajj, T R, Cummins, J A, Black   +3 more
openaire   +2 more sources