Results 31 to 40 of about 331,376 (161)
Frontiers in Cellular Neuroscience, 2018 Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation.
Mara Almog +4 more
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Dynamics of Sodium in Sodium Disilicate: Channel Relaxation and Sodium Diffusion [PDF]
Physical Review Letters, 2002 We use molecular dynamics computer simulations to study the dynamics of amorphous (Na_2O)2(SiO_2). We find that the Na ions move in channels embedded in a SiO_2 matrix. The characteristic distance between these channels gives rise to a prepeak in the structure factor at around q=0.95 A^-1.
Horbach, Juergen +2 more
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Scientific ReportsIn onion thrips Thrips tabaci, reduced sensitivity of the sodium channel caused by several sodium channel mutations have been correlated with pyrethroid resistance.
Akiya Jouraku +7 more
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Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. [PDF]
PLoS ONE, 2013 β subunits of mammalian sodium channels play important roles in modulating the expression and gating of mammalian sodium channels. However, there are no orthologs of β subunits in insects.
Lingxin Wang +3 more
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Functional expression of Rat Nav1.6 voltage-gated sodium channels in HEK293 cells: modulation by the auxiliary β1 subunit. [PDF]
PLoS ONE, 2014 The Nav1.6 voltage-gated sodium channel α subunit isoform is abundantly expressed in the adult rat brain. To assess the functional modulation of Nav1.6 channels by the auxiliary β1 subunit we expressed the rat Nav1.6 sodium channel α subunit by stable ...
Bingjun He, David M Soderlund
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Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7-1.9, cause human painful diseases.
Roberta eCarbonara +8 more
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Roles of Voltage-Dependent Sodium Channels in Neuronal Development, Pain, and Neurodegeneration
Journal of Pharmacological Sciences, 2006 Besides initiating and propagating action potentials in established neuronal circuits, voltage-dependent sodium channels sculpt and bolster the functional neuronal network from early in embryonic development through adulthood (e.g., differentiation of ...
Akihiko Wada
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The epithelial sodium channel and the control of sodium balance
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010 Studies aiming at the elucidation of the genetic basis of rare monogenic forms of hypertension have identified mutations in genes coding for the epithelial sodium channel ENaC, for the mineralocorticoid receptor, or for enzymes crucial for the synthesis of aldosterone.
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Skeletal Muscle Na+ Channel Disorders
Frontiers in Pharmacology, 2011 Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4.
Dina eSimkin, Saïd eBendahhou
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Salt, sodium channels, and SGK1 [PDF]
Journal of Clinical Investigation, 2007 The hormone aldosterone increases extracellular fluid volume and blood pressure by activating epithelial Na+ channels (ENaCs). Serum- and glucocorticoid-induced kinase 1 (SGK1) is an aldosterone-stimulated signaling molecule that enhances distal nephron Na+ transport, in part by preventing the internalization of ENaCs from the plasma membrane.
David, Pearce, Thomas R, Kleyman
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