Results 41 to 50 of about 331,376 (161)
A selectivity filter at the intracellular end of the acid-sensing ion channel pore
eLife, 2017 Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the
Timothy Lynagh +7 more
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Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC
Molecular Brain, 2019 This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero +7 more
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The tail of the cardiac sodium channel [PDF]
Channels, 2008 Addendum to: Human Heart Failure Is Associated With Abnormal C-Terminal Splicing Variants in the Cardiac Sodium Channel Lijuan L. Shang, Arnold E. Pfahnl, Shamarendra Sanyal, Zhe Jiao, Jon Allen, Kathrin Banach, John Fahrenbach, Daiana Weiss, W. Robert Taylor, A. Maziar Zafari, Samuel C. Dudley, Jr Circulation Research. 2007;101:1146.
Lijuan L, Shang +2 more
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Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
Scientific Reports, 2017 Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in the brain voltage-gated sodium channel gene SCN1A.
Lyndsey L. Anderson +4 more
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Novel Sodium Channel Inhibitor From Leeches
Frontiers in Pharmacology, 2018 Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function
Gan Wang +16 more
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Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents
Frontiers in Pharmacology, 2020 Based on recent findings, an increased late sodium current (INa,late) plays an important pathophysiological role in cardiac diseases, including rhythm disorders.
Balázs Horváth +9 more
doaj +1 more source
Journal of the Formosan Medical Association, 2008 Background/Purpose: Inward rectifying potassium channel 6.2 (Kir6.2 Δ C26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2 Δ C26 channel remains ...
Fan-Lu Kung +9 more
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Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice
Journal of Pharmacological Sciences, 2004 The effects of various sodium channel blocking agents on acute thermal and mechanical nociception, as assessed using the plantar and tail pressure tests, respectively, were compared with the effects of morphine. The drugs used were mexiletine, lidocaine,
Akiko Sakaue +3 more
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Na1.7 and Na1.8: Role in the pathophysiology of pain
Molecular Pain, 2019 Chronic pain is a significant unmet medical problem. Current research regarding sodium channel function in pathological pain is advancing with the hope that it will enable the development of isoform-specific sodium channel blockers, a promising treatment
Shaila Hameed
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Marine Toxins That Target Voltage-gated Sodium Channels
Marine Drugs, 2006 : Eukaryotic, voltage-gated sodium (NaV) channels are large membrane proteins which underlie generation and propagation of rapid electrical signals in nerve, muscle and heart. Nine different NaV receptor sites, for natural ligands and/or drugs, have been
Robert J. French +3 more
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