Results 61 to 70 of about 631,116 (302)

Influences: Sodium channel excitement [PDF]

Journal of General Physiology, 2018
Mandel reflects on the influence that a very broad training had on her scientific career.
openaire   +2 more sources

Matrix controlled channel diffusion of sodium in amorphous silica

, 2002
To find the origin of the diffusion channels observed in sodium-silicate glasses, we have performed classical molecular dynamics simulations of Na$_2$O--4SiO$_2$ during which the mass of the Si and O atoms has been multiplied by a tuning coefficient.
Bansal N, E Sunyer, Greaves G N, Greaves G N, Greaves G N, Guillot B, Heuer A, Horbach J, Horbach J, Huang C, Ingram M D, Ingram M D, Jund P, Kramer G J, Maass P, Meyer A, Oviedo J, P Jund, Porto M, R Jullien, Roling B, Schroder T B, Sidebottom D L, Sidebottom D L, Sunyer E, Sunyer E, van Beest B W H, Vessal B, Zotov N, Zotov N   +29 more
core   +1 more source

Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine [PDF]

, 2017
Asparagine is conserved in the S6 transmembrane segments of all voltage-gated sodium, calcium, and TRP channels identified to date. A broad spectrum of channelopathies including cardiac arrhythmias, epilepsy, muscle diseases, and pain disorders is ...
A Abdul-Gader, A Kreusch, A Lampert, AJ Miles, Alexandra B. Klinger, AM Powl, AM Powl, Andrew J. Miles, Andrias O. O’Reilly, Angelika Lampert, Anja Lattrell, AO O’Reilly, B Chanda, B Chanda, B Hille, B Nilius, B. A. Wallace, C Nau, C Nau, Carla Nau, D Ren, EC McCusker, F Lehmann-Horn, F Lehmann-Horn, FH Yu, G Cota, G Nurani, GK Wang, H Itoh, HM Berman, J Payandeh, J Payandeh, JG Lees, JM Gulbis, JW West, K Kwong, L Whitmore, L Whitmore, LE Browne, M Liao, MM McNulty, N Guex, N Sreerama, NB Cronin, NB Cronin, O Pongs, P Imbrici, PL Sheets, S Lee, SB Long, SB Long, SN Wright, T Hoshi, T Sugawara, T Zimmer, V Yarov-Yarovoy, V Yarov-Yarovoy, X Zhang, Y Chen, Y Zhao, YF Xiao   +60 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Roles of Voltage-Dependent Sodium Channels in Neuronal Development, Pain, and Neurodegeneration

Journal of Pharmacological Sciences, 2006
Besides initiating and propagating action potentials in established neuronal circuits, voltage-dependent sodium channels sculpt and bolster the functional neuronal network from early in embryonic development through adulthood (e.g., differentiation of ...
Akihiko Wada
doaj   +1 more source

Molecular basis of ion permeability in a voltage-gated sodium channel [PDF]

, 2016
Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials.
Altin Sula, Antonella Scaglione, BA Wallace, Bricogne G, Claire Bagnéris, Claire E Naylor, David E Clapham, Eswar N, Evans PR, Kabsch W, Paul G DeCaen, Zhang X   +11 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sodium Channels and Mammalian Sensory Mechanotransduction [PDF]

, 2012
Background: Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation.
Edith Hummler, Fan Wang, Francois Rugiero, Hannes Kiesewetter, John N Wood, Mohammed A Nassar, Rachel Hatch, Ramin Raouf   +7 more
core   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Skeletal Muscle Na+ Channel Disorders

Frontiers in Pharmacology, 2011
Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4.
Dina eSimkin, Saïd eBendahhou
doaj   +1 more source