Results 51 to 60 of about 331,376 (161)
Journal of Pain Research, 2012 Jinghong Chen,1,2,4 Ze-hui Gong,4 Hao Yan,2 Zhijun Qiao,3 Bo-yi Qin41Department of Internal Medicine, Neuroscience Program, The University of Texas Medical Branch, Galveston, TX, USA; 2The Divisions of Pharmacy, Pharmacology core lab, MD Anderson Cancer ...
Chen J, Gong Z, Yan H, Qiao Z, Qin B
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman +7 more
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Neurobiology of Disease, 2011 Mutations in the neuronal voltage-gated sodium channel genes SCN1A and SCN2A are associated with inherited epilepsies, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (severe myoclonic epilepsy of infancy).
Nicole A. Hawkins +4 more
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Traffic Jam at the Sodium Channel [PDF]
Epilepsy Currents, 2008 Modulatory Proteins Can Rescue a Trafficking Defective Epileptogenic Nav1.1 Na + Channel Mutant. Rusconi R, Scalmani P, Cassulini RR, Giunti G, Gambardella A, Franceschetti S, Annesi G, Wanke E, Mantegazza M. J Neurosci 2007;27(41):11037–11046.
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BMC Evolutionary Biology, 2007 Background Action potential generation in excitable cells such as myocytes and neurons critically depends on voltage-gated sodium channels. In mammals, sodium channels exist as macromolecular complexes that include a pore-forming alpha subunit and 1 or ...
Zhong Tao P +3 more
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Sodium ion channel mutations in glioblastoma patients correlate with shorter survival
Molecular Cancer, 2011 Background Glioblastoma Multiforme (GBM) is the most common and invasive astrocytic tumor associated with dismal prognosis. Treatment for GBM patients has advanced, but the median survival remains a meager 15 months.
Velculescu Victor E +3 more
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Drug Design, Development and Therapy, 2017 Marawan Ahmed,1 Horia Jalily Hasani,1,* Aravindhan Ganesan,1,* Michael Houghton,2–4 Khaled Barakat1–3 1Faculty of Pharmacy and Pharmaceutical Sciences, 2Li Ka Shing Institute of Virology, 3Li Ka Shing Applied Virology Institute, 4Department ...
Ahmed M +4 more
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Molecular Pain, 2006 Peripheral nerve injury is known to up-regulate the expression of rapidly-repriming Nav1.3 sodium channel within first-order dorsal root ganglion neurons and second-order dorsal horn nociceptive neurons, but it is not known if pain-processing neurons ...
Waxman Stephen G +2 more
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Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins
Toxinsµ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development.
Kirsten L. McMahon +2 more
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