Results 51 to 60 of about 631,116 (302)

First-Principles Study on Electron Conduction in Sodium Nanowire

, 2004
We present detailed first-principles calculations of the electron-conduction properties of a three-sodium-atom nanowire suspended between semi-infinite crystalline Na(001) electrodes during its elongation.
B?ttiker M, Chelikowsky J R, Costa-Kr?mer J L, Costa-Kr?mer J L, Datta S, Egami Y, Fujimoto Y, Hansen K, Kikuji Hirose, Krans J M, Lang N D, Lang N D, Messiah A, Ono T, Perdew J P, Sasaki T, Sim H S, Takashi Sasaki, Tomoya Ono, Troullier N, van Ruitenbeek J M, Yoshiyuki Egami   +21 more
core   +2 more sources

Failure to Downregulate the Epithelial Sodium Channel Causes Salt Sensitivity in Hsd11b2 Heterozygote Mice [PDF]

, 2012
In vivo, the enzyme 11β-hydroxysteroid dehydrogenase type 2 influences ligand access to the mineralocorticoid receptor. Ablation of the encoding gene, HSD11B2, causes the hypertensive syndrome of apparent mineralocorticoid excess.
Bailey, Matthew A, Craigie, Eilidh, Evans, Louise C, Mullins, John J   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Evolutionary origin and distribution of amino acid mutations associated with resistance to sodium channel modulators in onion thrips, Thrips tabaci

Scientific Reports
In onion thrips Thrips tabaci, reduced sensitivity of the sodium channel caused by several sodium channel mutations have been correlated with pyrethroid resistance.
Akiya Jouraku, Yui Tomizawa, Kazuki Watanabe, Kiyoshi Yamada, Seigo Kuwazaki, Misato Aizawa, Satoshi Toda, Shoji Sonoda   +7 more
doaj   +1 more source

Functional expression of Rat Nav1.6 voltage-gated sodium channels in HEK293 cells: modulation by the auxiliary β1 subunit. [PDF]

PLoS ONE, 2014
The Nav1.6 voltage-gated sodium channel α subunit isoform is abundantly expressed in the adult rat brain. To assess the functional modulation of Nav1.6 channels by the auxiliary β1 subunit we expressed the rat Nav1.6 sodium channel α subunit by stable ...
Bingjun He, David M Soderlund
doaj   +1 more source

MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter. [PDF]

, 2018
Sodium (Na+) is a ubiquitous and important inorganic salt mediating many critical biological processes such as neuronal excitation, signaling, and facilitation of various transporters.
Gonen, Tamir, Liu, Shian
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

Frontiers in Pharmacology, 2015
Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7-1.9, cause human painful diseases.
Roberta eCarbonara, Alessia eCarocci, Julien eRoussel, Giuseppe eCrescenzo, Canio eBuonavoglia, Carlo eFranchini, Giovanni eLentini, Diana eConte Camerino, Jean-François eDesaphy   +8 more
doaj   +1 more source

Do sodium channel proteolytic fragments regulate sodium channel expression? [PDF]

Channels, 2017
The cardiac voltage-gated sodium channel (gene: SCN5A, protein: NaV1.5) is responsible for the sodium current that initiates the cardiomyocyte action potential. Research into the mechanisms of SCN5A gene expression has gained momentum over the last few years.
Onwuli, Donatus O., Yañez-Bisbe, Laia, Pinsach-Abuin, Mel·lina, Tarradas, Anna, Brugada, Ramon, Greenman, John, Pagans, Sara, Beltran-Alvarez, Pedro   +7 more
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source