Results 71 to 80 of about 631,116 (302)

The conduction pore of a cardiac potassium channel. [PDF]

, 1998
Ion channels form transmembrane water-filled pores that allow ions to cross membranes in a rapid and selective fashion. The amino acid residues that line these pores have been sought to reveal the mechanisms of ion conduction and selectivity. The pore (P)
Goldstein, SA, Tai, KK
core  

Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels [PDF]

, 2017
Voltage-gated sodium channels enable the translocation of sodium ions across cell membranes and play crucial roles in electrical signaling by initiating the action potential.
Ahern, Ahuja, Altin Sula, Arrigoni, B.A. Wallace, Bagnéris, Bagnéris, Charalambous, DeCaen, DeCaen, Depienne, Fukuma, Gardella, Hille, Ito, Kapplinger, Koishi, Lenaeus, Li, McCusker, McNicholas, Mio, Naylor, Oelstrom, Payandeh, Payandeh, Powl, Qu, Ren, Shaya, Shen, Smart, Sula, Tang, Ulmschneider, Villalba-Galea, Zhang   +36 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A selectivity filter at the intracellular end of the acid-sensing ion channel pore

eLife, 2017
Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the
Timothy Lynagh, Emelie Flood, Céline Boiteux, Matthias Wulf, Vitaly V Komnatnyy, Janne M Colding, Toby W Allen, Stephan A Pless   +7 more
doaj   +1 more source

High glucose up-regulates ENaC and SGK1 expression in HCD-cells [PDF]

, 2006
Background/Aim: Diabetic nephropathy is associated with progressive renal damage, leading to impaired function and end-stage renal failure. Secondary hypertension stems from a deranged ability of cells within the kidney to resolve and appropriately ...
Bell LM, Bhargava A, Bland R, Christensen O, Claire Hills, Demerdash TM, Di Paolo S, Hoffman BB, Hong-Long JI, Jeanette Bennett, Khan ZA, Lang F, Lee CT, Lindschau C, Loffing J, Marshall SM, Paul Squires, Pierre Ronco, Prie D, Ricci C, Rosemary Bland, Rossier, Satlin LM, Sharma K, Symonian M, Urbach V, Waldegger S, Wang J, Weigert C, Whiteside CI, Yung S   +30 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC

Molecular Brain, 2019
This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected ...
Agustin Garcia-Caballero, Maria A. Gandini, Shuo Huang, Lina Chen, Ivana A. Souza, Yan L. Dang, M. Jackson Stutts, Gerald W. Zamponi   +7 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Novel Sodium Channel Inhibitor From Leeches

Frontiers in Pharmacology, 2018
Considering blood-sucking habits of leeches from surviving strategy of view, it can be hypothesized that leech saliva has analgesia or anesthesia functions for leeches to stay undetected by the host. However, no specific substance with analgesic function
Gan Wang, Chengbo Long, Weihui Liu, Cheng Xu, Min Zhang, Min Zhang, Qiong Li, Qiumin Lu, Qiumin Lu, Ping Meng, Dongsheng Li, Mingqiang Rong, Mingqiang Rong, Zhaohui Sun, Xiaodong Luo, Ren Lai, Ren Lai   +16 more
doaj   +1 more source

Sodium Channel Auxiliary Subunits

Microbial Physiology, 2007
Voltage-gated ion channels are well known for their functional roles in excitable tissues. Excitable tissues rely on voltage-gated ion channels and their auxiliary subunits to achieve concerted electrical activity in living cells. Auxiliary subunits are also known to provide functional diversity towards the transport and biogenesis properties of the ...
Tsai-Tien, Tseng, Allison M, McMahon, Victoria T, Johnson, Erwin Z, Mangubat, Robert J, Zahm, Mary E, Pacold, Eric, Jakobsson   +6 more
openaire   +2 more sources